Nanoparticles na bioactive waɗanda ke mayar da BBB jinkirin cutar Alzheimer a cikin mice

Un tawagar kasa da kasa, tare da jagoranci daga Cibiyar Bioengineering na Catalonia (IBEC) da asibitin yammacin kasar Sin na Jami'ar Sichuan. ya gabatar da dabarun nanotechnology cewa yana juyar da alamun cutar Alzheimer a cikin beraye ta hanyar gyara shingen kwakwalwar jini (BBB). A fadi magana, game da amfani da nanoparticles da suke aiki azaman kwayoyi da kansu zuwa mayar da cerebral jijiyoyin bugun gini aiki.

Wannan motsi a cikin mayar da hankali yana da ma'ana idan muka tuna da haka kwakwalwa tana cinyewa game da 20% na makamashi a cikin manya kuma har zuwa 60% a yara, goyan bayan babbar hanyar sadarwa na capillaries inda kowane neuron ke samun tallafi. Lokacin da aka canza BBB, tsarin zubar da shara yana shan wahala kuma yana jin daɗin tarin beta amyloid (Aβ), alamar cututtukan cututtuka.An yi kiyasin cewa kwakwalwar dan adam tana dauke da capillaries kusan biliyan daya, don haka muhimmancin lafiyar jijiyoyin jini.

Menene wannan dabarar nanotechnology ke bayarwa?

Ba kamar nanomedicine na gargajiya ba, wanda ke amfani da nanoparticles azaman abin hawa kawai, wannan hanyar tana aiki magungunan supramolecular waɗanda suke bioactive kuma basa buƙatar jigilar wata ka'ida. Manufar ba shine neuron ba, amma BBB a matsayin makasudin warkewa.

A karkashin yanayi na al'ada, Mai karɓar LRP1 yana gane Aβ kuma yana canza shi ta hanyar shinge zuwa cikin jiniTsarin, duk da haka, yana da laushi: Idan ɗaurin ya wuce kima ko bai isa ba, sufuri ba shi da daidaituwa kuma Aβ yana taruwa. Nanoparticles da aka tsara Farashin LRP1 don dawo da daidaiton.

Tare da wannan tsoma baki, hanyar fita daga sunadarai masu matsala daga parenchyma cikin jini, yana haɓaka aikin Aβ da daidaita aikin shinge. A takaice, yana sake kunnawa hanyar tsarkakewa ta halitta na kwakwalwa.

Gwajin samfurin dabba da sakamako

An gudanar da kimantawa akan berayen da aka gyara ta hanyar kwayoyin halitta don samar da adadi mai yawa na Aβ da haɓaka rashin fahimta. Allura guda uku na waɗannan barbashi sun isa don lura da canje-canje masu ma'auni a cikin alamomin halitta da ɗabi'a..

A cewar marubutan. awa daya kacal bayan gudanarwa An riga an yi rikodin raguwar 50-60% a cikin Aβ a cikin kwakwalwaSaurin tasirin yana ba da shawarar sake kunna tsarin jigilar kayayyaki nan da nan a kan shingen.

Bayan tasirin tasirin nan da nan, an kwatanta tasirin dindindin. A cikin gwaji ɗaya, an sake gwada linzamin kwamfuta mai watanni 12 a cikin watanni 18 kuma an nuna shi. aiki mai kama da na dabba mai lafiya, yana nuna ci gaba da dawowa aiki bayan jiyya.

Tawagar ta fassara cewa akwai a sarkar tasiri: ta hanyar maido da aikin jijiyoyin jini, Amincewa da Aβ da sauran ƙwayoyin cuta masu cutarwa sun dawo, kuma tsarin ya dawo da ma'auni.. A cikin kalmomin jagorancin kimiyya, barbashi suna aiki kamar magani wanda yana sake kunna hanyar kawarwa zuwa matakan al'ada.

Kwararru na waje sun bayyana binciken a matsayin abin al'ajabi, kodayake sun nuna cewa an samu sakamakon a cikin murine model kuma wannan fassarar ga marasa lafiya na buƙatar taka tsantsan. Al'umma suna jaddada buƙatar tabbatar da aminci da inganci a cikin mutane tare da tsayayyen karatu.

Injiniyan kwayoyin halitta a bayan nanoparticles

Wadannan nanoparticles suna cikin ciki tare da kusanci na injiniyan kwayoyin halitta, hada girman sarrafawa tare da a ƙayyade adadin ligands a saman sa don yin hulɗa tare da masu karɓa ta wata hanya ta musamman.

Ta hanyar daidaitawa zirga-zirgar mai karɓa a cikin membranes, Barbashi suna daidaita tsarin fassarar Aβ a cikin BBBWannan matakin madaidaicin yana buɗe hanyoyi don daidaita ayyukan mai karɓa wanda har ya zuwa yanzu yana da wahala a iya sarrafa shi ta hanyar warkewa.

Don haka, ba wai kawai an inganta ingantaccen kawar da Aβ ba, amma Yana taimakawa wajen daidaita jijiyoyi masu ƙarfi waɗanda ke tallafawa aikin kwakwalwa lafiya.. Wannan babban bambanci ne daga hanyoyin da aka iyakance zuwa isar da magunguna.

Wanene ke halarta kuma me zai biyo baya?

Ƙungiya ta haɗu da Farashin IBEC, Asibitin yammacin kasar Sin da asibitin Xiamen na yammacin kasar Sin na jami'ar Sichuan, da Jami'ar College London, da Jami'ar Barcelona, ICREA, da Cibiyar Nazarin Kiwon Lafiya ta kasar Sin, da sauransu. An buga sakamakon binciken a cikin mujallar Canja wurin sigina da Farfagandar Niyya.

Dangane da fassarar, hanya mai ma'ana ta wuce ingantacce masu zaman kansu, Nazarin toxicological, nazarin kashi kuma, idan ya dace, gwajin ɗan adam na lokaci I / IIAminci da sakewa za su zama mabuɗin ci gaba.

Bayan Alzheimer's, wannan aikin yana mai da hankali kan lafiyar cerebrovascular a matsayin mahimmin kashi na hauka, Buɗe filin warkewa wanda ya dace da hanyoyin da suka shafi neuron na gargajiya.

Saitin bayanan ya nuna cewa shiga tsakani akan shingen kwakwalwar jini tare da bioactive nanoparticles zai iya hanzarta rage nauyin amyloid, mayar da aikin jijiyoyin jini, da inganta sakamakon fahimi a cikin mice; hanya mai ban sha'awa wanda, tare da taka tsantsan, ya kamata a tabbatar da shi karatun asibiti da kyau tsara.