He kuleana koʻikoʻi nā protein membrane cell me kahi hana transport i ka hoʻoponopono ʻana i ke kahe ʻana o nā molekala a me nā ion ma o ka membrane cell. ʻO kēia mau protein ke kuleana no ka mālama ʻana i ke koena o loko i loko o nā cell, e ʻae ana i ke ala koho o nā mea pono no ka hana kelepona. Ma o nā ʻano hana like ʻole, hoʻomaʻamaʻa kēia mau protein i ka lawe ʻana i nā molekala hydrophobic, hydrophilic, a i hoʻopaʻa ʻia ma waena o ka membrane, e pāʻani ana i kahi kuleana nui i nā kaʻina hana physiological. Ma kēia ʻatikala, e ʻimi kikoʻī mākou i nā hiʻohiʻona a me nā hana o nā protein membrane cell me kahi hana lawe, a me ko lākou pili i ke olakino a me ka hana maʻamau o nā cell.
ʻO ka hoʻolauna ʻana i nā protein membrane cell me ka hana lawe
ʻO nā protein membrane cell me kahi transport function he mau mea nui ia no ka hana pono o nā cell the. ʻO kēia proteins ke kuleana no ka hoʻomaʻamaʻa i ka neʻe ʻana o nā molekala a me nā iona ma o ka membrane cell, e ʻae i ke komo ʻana a me ka puka ʻana o nā mea pono no ke ola a me ka hana pono o ke kelepona.
Aia nā ʻano like ʻole o nā protein transport i loko o ka membrane cell, kēlā me kēia mea kūikawā i ka lawe ʻana i kahi ʻano mole a ion paha. Ke hana nei kekahi o kēia mau protein ma ke ʻano he ala ion, e ʻae ana i ke ala koho o nā ion ma o ka membrane. Ke hana nei nā protein ʻē aʻe ma ke ʻano he transporters, hoʻopaʻa i ka mole e lawe ʻia a hoʻololi i ka conformation e hoʻokuʻu iā ia i loko a i waho paha o ke kelepona. Aia pū kekahi mau protein transport e hana ana e like me nā pamu, me ka hoʻohana ʻana i ka ikehu e hoʻoneʻe i nā molekala e kūʻē i kā lākou gradient.
Pono pono nā protein transport i loko o ka membrane cell no ka mālama ʻana i ke koena o nā mea i loko a ma waena o nā cell. Hāʻawi kēia mau protein i ka lawe ʻana i nā meaʻai, ka hoʻopau ʻana i ka ʻōpala, ka hoʻoponopono ʻana i ka ʻike ion a me ke kamaʻilio ʻana ma waena o nā cell ma o ka lawe ʻana i nā hōʻailona kemika. Eia kekahi, he kuleana koʻikoʻi kekahi o nā protein transport i ka pale ʻana i ke kelepona, ma ka hana ʻana ma ke ʻano he pale koho e pale ai i ka hele ʻana o nā mea ʻino a makemake ʻole paha. I ka hōʻuluʻulu ʻana, ʻo nā protein o ka membrane cell me kahi hana halihali he mau mea koʻikoʻi ia e hōʻoiaʻiʻo ai i ka hana kūpono a me ke ola ʻana o nā cell.
Ka hoʻohui ʻana a me ka hoʻolālā ʻana o nā protein membrane cell me ka hana lawe
ʻO nā protein membrane cell me kahi hana halihali he mau hale koʻikoʻi no ka hana pono o ke kelepona. Hāʻawi kēia mau protein i ke ala koho o nā mea ma waena o ka membrane a pāʻani i kahi kuleana koʻikoʻi i ke koena o loko o ka cell.
ʻOkoʻa ke ʻano o kēia mau protein ma muli o kā lākou hana kikoʻī, akā naʻe, ʻo ka hapa nui o nā waikawa amino hydrophobic e launa pū me nā ʻāpana lipid o ka lipid bilayer o ka membrane.
Hōʻike ʻia ke ʻano o nā protein membrane cell me kahi hana transport e ka hele ʻana o nā transmembrane alpha helices. Ke hele nei kēia mau helices i ka lipid bilayer a hana i nā ala e hiki ai i nā molekole ke hele. Eia kekahi, i kekahi mau hihia, hiki i kēia mau protein ke loaʻa i nā kikowaena hou e pili ana me nā mea i lawe ʻia a hoʻoponopono i ko lākou ala ma waena o ka membrane.
Nā Hana Koʻikoʻi o nā Pale Membrane Cell me ka hana lawe
He kuleana koʻikoʻi nā protein membrane cell me kahi hana transport i ke kaʻina hana o ka lawe ʻana i nā molekala a me nā mea ma waena o ka membrane cell. Hoʻokomo ʻia kēia mau protein i loko o ka lipid bilayer o ka membrane a nona ke kuleana no ka hoʻoponopono ʻana i ke kahe o nā ion, solutes, a me nā biomolecules i loko a i waho o ke kelepona. Aia ma lalo iho kekahi o nā kuleana koʻikoʻi e pāʻani nei kēia mau protein i ka lawe kelepona.
ʻano kikoʻī o ka substrate: Hōʻike nā protein transport membrane cell i kahi kikoʻī kiʻekiʻe i ke koho ʻana i nā substrate. Hoʻolālā ʻia kēlā me kēia protein transport e lawe i kahi ʻano kikoʻī o mole a ion ma waena o ka membrane cell. Mālama kēia i ka lawe ʻana i nā mea e pono ai no ka hana kelepona.
ʻO ka gradient concentrate: Hoʻohana maikaʻi kēia mau protein i nā gradients noʻonoʻo e "neʻe" i nā molekala ma waena o ka membrane cell. Hiki iā lākou ke lawe i nā molekala ma ke ala o ka gradient kuʻekuʻe (passive transport) a i ʻole (transsive transport) ke hoʻohana nei i ka gradient kuʻuna mua e hoʻomaʻamaʻa i ka neʻe ʻana o nā molekala, ʻoiai ʻo ka lawe ikaika e pono ai ka ikehu gradient a hoʻoneʻe i nā molekala i ka gradient.
Nā ʻano o nā ʻano ʻano o nā ʻano o nā pūlaʻa me nā ʻano o ka lawe ʻana
ʻO nā protein o ka membrane cell me kahi hana halihali he mea nui ia no ka hana pono o nā cell, no ka mea, ʻae lākou i ka lawe ʻana i nā molekole like ʻole ma waena o ka membrane. He kuleana koʻikoʻi kēia mau protein i ka homeostasis a me ka hōʻailona cell, e hōʻoia ana i ke komo ʻana a haʻalele i ka cell i ka manawa kūpono.
Nui nā ʻano protein transport i loko o ka membrane cell, kēlā me kēia me nā ʻano kikoʻī a me nā hana. Aia kekahi o nā ʻano maʻamau:
- Nā pūmua lawe lawe: ʻO kēia mau protein ke kuleana no ka hoʻomaʻamaʻa ʻana i ka lawe ʻana o nā molekole ma waena o ka membrane, ma o ka lawe ʻana a i ʻole ka lawe passive. ʻO kekahi mau hiʻohiʻona o nā protein transport he permeases a me nā paila ion.
- Nā kahawai Ion: Hoʻokumu kēia mau polokina i nā pores i loko o ka cellular membrane, e ʻae i ka hele ʻana o nā ion kikoʻī ma ke koho. He mea koʻikoʻi kēia mau kahawai no ka hana ʻana a me ka hoʻolaha ʻana o impulses uila i loko o nā pūnaewele a me nā ʻiʻo.
- Exonucleases a me endonucleases: ʻO kēia mau enzymes ke kuleana no ka hōʻino ʻana a me ka hoʻoponopono ʻana i nā mea genetic i loko o ke kelepona. Mahalo iā lākou, hiki ke mālama i ka paʻa a me ka pono o DNA a me RNA.
He mau laʻana wale nō kēia o ka . He kuleana koʻikoʻi kēlā me kēia mau protein i ka mālama ʻana i ka homeostasis cellular a me ka hoʻoponopono ʻana i nā kaʻina biochemical. ʻO kāna aʻo ʻana a me kāna ʻike he mea nui ia e holomua i ka ʻike o ka cell biology a me ka hoʻomohala ʻana i nā lāʻau lapaʻau hou.
Mechanisms of action of Cell Membrane Proteins with Transport Function
He kuleana koʻikoʻi nā protein membrane cell i ka lawe ʻana i nā molekole ma waena o ka membrane plasma. Loaʻa i kēia mau protein nā hana hana kūikawā e hiki ai iā lākou ke maʻalahi i ka lawe ʻana i nā mea ma waena o ka membrane. ala kūpono a koho. Aia ma lalo iho kekahi o nā hana koʻikoʻi o kēia mau protein:
1. Hoʻolaha maʻalahi: Ke hana nei kekahi mau polokina i loko o ka membrane cell ma ke ʻano he awāwa a i ʻole pores e hiki ai i nā molekole ke hoʻopuehu me ka hele ʻana ma hope o ka gradient. Hāʻawi kēia mau protein i ka hele ʻana o nā mea kikoʻī, e like me nā ion a me nā molekole liʻiliʻi, ma o ka membrane cell.
2. ʻO ka halihali ʻana: ʻO kekahi hana koʻikoʻi o nā protein membrane cell he transport active, kahi e hoʻohana ʻia ai ka ikehu no ka hoʻoneʻe ʻana i nā molekala e kūʻē i kā lākou gradient kuʻuna. Lawe ʻia kēia ʻano kaʻa e nā protein transport a i ʻole nā pump membrane, e hoʻohana ana i ka ATP i kumu ikehu.
3. Kaʻi hui pū: Hiki i kekahi mau pūmua membrane cell ke lawe i ʻelua a ʻoi aku mau mea ma o ka membrane. ʻIke ʻia kēia kaʻina hana he cotransport a hiki ke lawe ʻia e ka cotransport ma ke ala like (symporters) a i ʻole ma kahi ʻaoʻao (antiporters). He mea nui kēia mau mīkini lawe like no ka hana maʻamau o ke kelepona a ʻae i ka absorption o nā meaʻai a me ka hoʻopau ʻana i ka ʻōpala.
ʻO ke koʻikoʻi koʻikoʻi o nā protein membrane cell me ka hana lawe
ʻO nā protein membrane cell me kahi hana halihali he mea koʻikoʻi i ka mālama ʻana i ka homeostasis a me ka hana pono o nā cell. ʻO kēia mau protein ke kuleana no ka lawe ʻana i nā ʻano mole a me nā ion ma waena o ka membrane cell, e ʻae i ke komo ʻana a me ka puka ʻana o nā mea koʻikoʻi no ka hana cell. Aia ma lalo iho nā kumu nui i koʻikoʻi ai kēia mau protein mai kahi ʻano olaola.
Hoʻoponopono i ke kaulike ionic: Pono nā protein transport membrane cell no ka mālama ʻana i ke koena kūpono o nā ion i loko a ma waho o ke kelepona. ʻO kēia mau ion, e like me ka sodium, potassium, a me ka calcium, he kuleana koʻikoʻi i ka lawe ʻana i nā hōʻailona ma waena o nā pūnaewele a me ka hana ʻana o ka ikehu cellular. Hoʻomaʻamaʻa nā protein transport i ke komo ʻana a me ka puka ʻana o kēia mau ion, e ʻae ana i kahi kaulike ionic maikaʻi loa e mālama ʻia no ka hana kelepona.
Ka lawe ʻana i nā meaʻai a me nā metabolites: ʻO nā protein transport i loko o ka membrane cell ke kuleana no ka lawe ʻana i nā meaʻai, e like me nā amino acids a me ka glucose, i loko o ke kelepona pono kēia mau molekele no ka synthesis protein a me ka hana ʻana o ka ikehu. Eia kekahi, pili pū nā protein transport i ka lawe ʻana i ka ʻōpala a me ka lawe ʻana i nā metabolites mai loko mai o ke kelepona.
Ka mālama ʻana i ka pono o ke kelepona: He kuleana koʻikoʻi nō hoʻi nā protein transport i ka mālama ʻana i ka pono a me ke koho koho o ka membrane cell. Mālama kēia mau protein i ke komo ʻana a me ka puka ʻana o nā mea kikoʻī, e pale ana i ke komo ʻana o nā mea ʻawaʻawa a i ʻole nā mea pōʻino no ke kelepona. Eia kekahi, pili pū lākou i ke kamaʻilio ʻana ma waena o nā pūnaewele kokoke a me ka hoʻopili ʻana i ke kelepona.
Ka pilina ma waena o Cell Membrane Proteins me Transport Function a me nā maʻi kanaka
He mea koʻikoʻi nā protein membrane cell no ka hana pono ʻana o nā cell a he kuleana koʻikoʻi i ka lawe ʻana i nā mea ma waena o ka membrane Ka pilina ma waena o kēia mau protein a me nā maʻi kanaka.
Aia nā ʻano like ʻole o nā protein membrane e komo i ka lawe ʻana i nā mea. Ma kekahi ʻaoʻao, ʻike mākou i nā protein transport, kuleana no ka hoʻomaʻamaʻa ʻana i ka neʻe ʻana o nā molekole kikoʻī ma waena o ka membrane. Hiki i kēia mau protein ke ʻelua ʻano: uniport, nāna e lawe i hoʻokahi mea, a me cotransport, nāna e lawe i ʻelua a ʻoi aku paha nā mea i ka manawa like. ʻO kahi hiʻohiʻona kūpono o kahi maʻi e pili ana i nā pilikia i ka hana o kēia mau protein he cystic fibrosis, kahi i loaʻa ai kahi dysfunction i nā kahawai chloride, e pili ana i ka huna ʻana o ka mucus.
Ma ka ʻaoʻao ʻē aʻe, aia nā protein channel, e hana ana i nā pores i loko o ka membrane a ʻae i ke ala koho o nā ion a me nā molekole liʻiliʻi. Pono kēia mau protein i nā hana e like me ka hoʻouna ʻana i nā hōʻailona uila i nā neurons. ʻO nā maʻi e like me ka myotonia congenita a i ʻole ka maʻi maʻi maʻi ma muli o ka hoʻololi ʻana i nā protein channel, kahi e hoʻololi ai i ka excitability o ka ʻiʻo a me nā hōʻailona e like me ka nāwaliwali a me ka hiki ʻole ke hoʻomaha i nā ʻiʻo.
Nā noʻonoʻo kūpono no ke aʻo ʻana a me ka nānā ʻana o nā Membrane Cell Proteins me ka hana lawe
ʻO ke aʻo ʻana a me ka nānā ʻana o nā protein cellular membrane me kahi hana lawe he mea koʻikoʻi ia e hoʻomaopopo i nā hana e hoʻoponopono ai i ka lawe ʻana o nā mea ma waena o nā membrane cell. Ma lalo iho, e hōʻike ʻia kekahi mau manaʻo kūpono e pono ai i kēia ʻano haʻawina:
Nā ʻenehana hoʻomaʻemaʻe:
- Pono e hoʻomaʻemaʻe i nā protein o ka membrane cell i hiki ke aʻo pono iā lākou. ʻO ka technique maʻamau ka polyacrylamide gel electrophoresis.
- He mea nui e noʻonoʻo e pili ana i nā protein o ka membrane cell i nā loli i ka pH a me ka mahana, no laila pono e hoʻokō i ka hoʻomaʻemaʻe ma lalo o nā kūlana kūpono.
- Manaʻo ʻia e hoʻohana i nā puʻupuʻu ikaika ionic haʻahaʻa i ka wā hoʻomaʻemaʻe e pale aku i ka pōʻino i ke ʻano protein.
Nā hoʻokolohua hana:
- Ma hope o ka hoʻomaʻemaʻe ʻia ʻana o nā protein membrane cell, pono ia e hana i nā hoʻokolohua hana e hoʻoholo ai i kā lākou hana lawe ʻana i kēia mau ho'āʻo ʻana paha i nā ana o ka hoʻokele substrate a i ʻole ka lawe pū ʻana i nā mea.
- He mea nui e hoʻokō i nā hoʻokolohua hana ma lalo o nā kūlana physiological e loaʻa ai nā hopena kūpono. Hoʻopili kēia i ka mālama ʻana i ka wela kūpono, ka pH, a me nā ʻona ion.
- Manaʻo ʻia e hoʻohana i nā mana maikaʻi a maikaʻi ʻole i nā hoʻokolohua hana e hōʻoia i nā hopena i loaʻa.
Nānā i ka hanana:
- No ka hoʻomaopopo piha ʻana i ka hana o nā protein membrane cell, pono ia e hana i ka nānā ʻana. ʻO ka ʻenehana i hoʻohana nui ʻia no kēia kumu ʻo X-ray crystallography, e hiki ai ke hoʻoholo i ke ʻano ʻekolu-dimensional o nā protein.
- He mea nui ka hoʻomaopopo ʻana he mea paʻakikī ka crystallization o nā protein membrane cell ma muli o ko lākou ʻano hydrophobic.
- Ke loaʻa nā kristal, hiki ke hoʻohana ʻia nā ʻano hana like ʻole, e like me ka microscopy electron, e nānā i ke ʻano ʻekolu-dimensional o nā protein membrane cell me ka hoʻonā kiʻekiʻe.
Nā Manaʻo no ka hoʻoponopono ʻana i nā Cell Membrane Proteins me ka Transport Function in vitro hoʻokolohua.
Ka lawelawe pono ʻana i nā hoʻokolohua in vitro
He mea koʻikoʻi koʻikoʻi nā protein membrane cell me kahi hana halihali i ka hoʻoponopono ʻana i ke kahe o nā mea ma o nā cell. ʻO nā hoʻokolohua in vitro, pono e hahai i kekahi mau ʻōlelo aʻoaʻo e hōʻoia ka hoʻoponopono pono ʻana o kēia mau protein a loaʻa nā hopena hilinaʻi. Eia kekahi mau ʻōlelo manaʻo nui:
1. Hoʻomākaukau a mālama
- E hoʻopaʻa i nā protein ma lalo o nā kūlana hoʻoheheʻe laminar i hoʻopaʻa ʻia e pale aku i ka haumia a hōʻoia i ka pono o ka laʻana.
- E mālama i nā polokina i loko o kahi anuanu (-80°C) a pale i nā pōʻai hoʻoheheʻe pinepine i mea e pale ai i ka hōʻino a me ka nalowale o ka hana.
- E hoʻohana i kahi pale kūpono e mālama i ka pH a me ka paʻa o nā protein i ka wā o ka hoʻokolohua.
2. Nā ʻenehana unuhi
- E hoʻohana pono i nā ʻenehana unuhi kūpono e mālama i ke ʻano a me ka hana o nā protein. Hiki i kēia ke hoʻohana i nā mea hoʻomaʻemaʻe haʻahaʻa, nā hoʻonā isotonic a me nā pale kikoʻī.
- E hōʻalo i ka loaʻa ʻana o nā protein i ka māmā a me ka wela, no ka mea hiki iā lākou ke hōʻeha ʻole.
3. Hoʻoponopono i ka wā o ka hoʻokolohua
- E nānā pono i ka mahana a me ka pH i ka wā o ka hoʻokolohua e mālama i nā kūlana kūpono no ka hana protein.
- E hoʻohana i nā ala ʻike kūpono, e like me ka spectroscopy, e nānā i ka hana protein i ka wā o ka hoʻokolohua a hana i nā hoʻololi inā pono.
Ma ka hahai ʻana i kēia mau ʻōlelo aʻoaʻo, e hōʻemi ʻia nā ʻano like ʻole e pili ana i ka hana a me ka pololei o nā protein membrane cell me kahi hana transport, e ʻae ana i nā hopena pololei a hilinaʻi i nā hoʻokolohua in vitro.
Nā pilikia a me nā hiʻohiʻona o ka wā e hiki mai ana i ka noiʻi ʻana o Cell Membrane Proteins me ka hana lawe
Desafíos
ʻO ka noiʻi ʻana i ka Cell Membrane Proteins me ka Transport Function ka mea nui i nā pilikia ma muli o ka paʻakikī o kēia mau ʻōnaehana olaola. ʻO kekahi o nā pilikia koʻikoʻi a ka poʻe ʻepekema e kū nei ma kēia wahi:
- Nā hiʻohiʻona i kūkulu ʻia: He mea nui ka noiʻi ʻana i nā ʻano hana ʻekolu o kēia mau protein e hoʻomaopopo i kā lākou hana a me ke ʻano o ka hana. Eia nō naʻe, ʻo ka loaʻa ʻana a me ka hoʻoholo pololei ʻana i kēia mau hale he mea paʻakikī ʻenehana ma muli o ko lākou hydrophobicity kiʻekiʻe a me ka nele o nā ʻano crystallization kūpono.
- Nā mīkini hoʻokele: ʻO ka lawe ʻana i nā molekala ma waena o ka membrane cell he kaʻina hana paʻakikī e pili ana i nā pilina ikaika ma waena o nā protein transport a me ko lākou wahi lipid. No ka hoʻomaopopo ʻana i nā kikoʻī molekala o kēia mau mīkini pono e hoʻohana i nā ʻenehana holomua, e like me ka nuclear magnetic resonance spectroscopy a me cryo-electron microscopy.
- Hoʻoponopono a modulation: Hoʻopili pinepine ʻia ka Cell Membrane Proteins me ka Transport Function i ka hoʻoponopono a me ka modulation e nā hōʻailona intracellular a me nā lāʻau lapaʻau. ʻO ka hoʻomaopopo ʻana i ka pane ʻana o kēia mau protein i nā hōʻailona like ʻole a me ka hopena o kā lākou hana e nā lāʻau lapaʻau he mea nui ia no ka hoʻomohala ʻana i nā lāʻau lapaʻau a me ka pale ʻana i nā maʻi.
Nā hiʻohiʻona o ka wā e hiki mai ana
ʻOiai aia nā pilikia i ka noiʻi ʻana i nā Cellular Membrane Proteins me ka Transport Function, aia kekahi mau manaʻo hoihoi i ka wā e hiki mai ana e hiki ke kamaʻilio ʻia ma o ka holomua ʻenehana a me ka hoʻohana ʻana i nā ʻano interdisciplinary. Aia kekahi o kēia mau hiʻohiʻona:
- Nā holomua i nā ʻenehana kiʻi: ʻO ka hoʻomaikaʻi mau ʻana o nā ʻenehana kiʻi, e like me ka microscopy super-resolution a me ka microscopy atomic force, e ʻae i ka nānā kikoʻī ʻana i nā protein membrane cell i ka hana, e hāʻawi ana i ka ʻike waiwai e pili ana i kā lākou hana a me ka dynamics.
- ʻO ka ʻōnaehana biology ala: ʻO ka hoʻohui ʻana i ka ʻikepili nui a me ka hoʻopaʻa ʻana i ka hoʻopili helu ʻana e ʻae i ka hoʻomaopopo piha ʻana i nā ʻoihana pili ma waena o Cell Membrane Transport Proteins a me nā mea kelepona ʻē aʻe. Hiki i kēia ke hōʻike i nā ala hōʻailona hou a me nā hoʻolālā therapeutic.
- Hoʻolālā o nā lāʻau i hoʻopaʻa ʻia: ʻO ka hui pū ʻana i ka ʻike kūkulu a me ka hana o Transport Function Cell Membrane Proteins me nā ʻenehana hoʻohālikelike molecular holomua hiki ke hoʻomaikaʻi maikaʻi i ka hoʻolālā ʻana o nā lāʻau e koho koho i kēia mau protein, hiki ke loaʻa ka hopena maikaʻi i ka mālama ʻana i nā maʻi like ʻole.
Nā manaʻo hoʻoholo ma ka Cell Membrane Nā Proteina me ka hana lawe
He kuleana koʻikoʻi nā protein membrane cell i ka lawe ʻana i nā molekole ma waena o ka membrane. Pono kēia mau protein no ke ola ʻana o nā pūnaewele, no ka mea, ʻae lākou i ka hoʻololi ʻana o nā mea ma waena o ke kaiapuni extracellular a me intracellular. Ma kēia manaʻo, ʻo nā protein membrane me kahi hana lawe kaʻa he mea kūikawā loa a kikoʻī no nā ʻano mole. Ua hōʻike kā lākou noiʻi ʻana i nā hopena koʻikoʻi.
ʻO ka mea mua, ua hōʻike ʻia ua hoʻoponopono nui ʻia nā protein membrane cell me kahi hana transport. Kāohi pono ʻia kāna hōʻike a me kāna hana e nā ʻano mea like ʻole. Aia kēia mau mea i nā hōʻailona kemika, nā hoʻololi i ke kaiapuni kelepona, a me kahi ʻano o nā protein hoʻoponopono kikoʻī. Pono kēia hoʻoponopono pololei e hōʻoia i kahi kaulike kūpono i ka lawe ʻana i nā molekala a mālama i ka homeostasis cellular.
Eia kekahi, ua ʻike ʻia ʻo nā protein transport i loko o ka membrane cell hiki ke launa pū kekahi me kekahi. Ma o ka hoʻokumu ʻana i nā paʻakikī protein, hiki i kēia mau protein ke hana like a hoʻomaʻamaʻa i ka lawe pū ʻana o nā molekole. Pono paha kēia hui ʻana no ka lawe ʻana i nā molekala nui a i ʻole no ka lawe pono ʻana i nā hiʻohiʻona kikoʻī. No laila, ʻo ke aʻo ʻana i nā protein transport ʻaʻole wale nō e pili ana i ka nānā ʻana o kēlā me kēia protein, akā ʻo nā pilina ma waena o lākou.
Nā Manaʻo Bibliographic ma Cell Membrane Proteins me ka hana lawe
1. García-Sáez AJ, et al. (2007). ʻO ke ʻano biophysical o nā protein membrane i nā bilayers planar i kākoʻo ʻia e ka microscopy fluorescence a me ka microscopy ikaika atomic.I loko Meth Enzymol. 418:247-65. DOI: 10.1016/S0076-6879(06)18016-X.
2. Muller DJ, et al. (2011). ʻO ka microscopy ikaika atomika no ka biology mole hoʻokahi.ma Cell Tissue Res. 329(1): 205–219. DOI: 10.1007/s00441-006-0308-3.
3. Ziegler C, et al. (2005). Hoʻouna electron microscopy o biological specimens: he alakaʻi kūponoI loko Nā Hana Pūnaewele Pūnaewele. 79: Waltham, Massachusetts: Academic Press. 99–114. DOI: 10.1016/S0091-679X(05)79004-3.
Nā ʻenehana i hoʻohana ʻia i ka noiʻi ʻana i ka protein membrane
- ʻO ka microscopy fluorescence.
- Microscopy ikaika ʻātoma.
- Microscopy electron hoʻouna.
ʻO kēia mau puke puke e hoʻopuka i nā ʻenehana like ʻole i hoʻohana ʻia no ke aʻo ʻana i nā protein membrane cell me kahi hana lawe. Pono ke aʻo ʻana i kēia mau protein e hoʻomaopopo i ko lākou ʻano, hana a me nā mīkini lawe i loko o ke kelepona. ʻO ka microscopy fluorescence hiki iā mākou ke nānā a nānā i ka pilina o nā protein me nā membrane cell, aʻo ka microscopy atomic ikaika e hāʻawi i ka ʻike kikoʻī e pili ana i nā waiwai kino o nā protein a me kā lākou pilina me nā membrane. Ma ka ʻaoʻao ʻē aʻe, ʻo ka microscopy electron transmission kahi ʻenehana loea e hiki ai i ke kiʻi kiʻi kiʻekiʻe o nā protein membrane i ko lākou ʻāina maoli.
Nīnau a me nā Pane
Nīnau: He aha nā protein membrane cell me kahi hana lawe?
A: ʻO nā protein membrane cell me kahi hana halihali he ʻano protein i loaʻa i loko o ka membrane plasma a loaʻa iā ia ka hiki ke hoʻomaʻamaʻa i ka hele ʻana o nā molekole kikoʻī ma o kēia pale semipermeable.
Nīnau: He aha ka hana o kēia mau protein i loko o ke kelepona?
A: ʻO ka hana nui o nā protein membrane cell me kahi hana transport e ʻae i ka lawe koho ʻana o nā mea ma waena o ka membrane plasma. Ke hana nei kēia mau protein ma ke ʻano he transporters e hoʻomaʻamaʻa i ka hele ʻana o nā ion, nā meaʻai, nā metabolites a me nā pūhui ʻē aʻe e pono ai no ka hana pono o ke kelepona.
Nīnau: Pehea e hoʻokō ʻia ai kēia kaʻina kaʻa?
A: Aia nā ʻano hana lawe like ʻole i hoʻopili ʻia e nā protein membrane cell. Hoʻopili kēia i ka hoʻopuehu maʻalahi, ka lawe ʻana i ka hana mua, ka lawe ʻana i ka lua, a me ka endocytosis/exocytosis. Hoʻopili ʻia kēlā me kēia mīkini me kahi pūmua kikoʻī nona ke kuleana no ka hoʻopili ʻana i ka hele ʻana o kekahi mau solutes ma o ka membrane.
Nīnau: He aha ka mea nui o kēia mau proteins i loko o ke ola kelepona?
A: Pono nā protein membrane cell me kahi hana halihali e mālama i ka homeostasis a me ke koena kemika pono i loko o ke kelepona. Eia kekahi, ʻae lākou i ke kelepona e loaʻa i nā meaʻai pono a hoʻopau i nā huahana ʻōpala. Me ka ʻole o kēia mau protein, ʻaʻole hiki i ka cell cell ke hana i nui kāna mau hana vitales.
Nīnau: He aha ka hana inā aia nā hoʻololi i kēia mau protein?
A: Hiki i nā hoʻololi ʻana i nā protein o ka membrane cell me kahi hana halihali ke loaʻa i nā hopena koʻikoʻi no ke kelepona a me ke kino holoʻokoʻa. No ka laʻana, hiki i ka hoʻololi ʻana i nā genes e hoʻopili i kēia mau protein ke kumu i nā maʻi genetic i kapa ʻia ʻo nā maʻi transport. ʻO kēia mau maʻi i hōʻike ʻia e ka hiki ʻole o ke kelepona ke lawe pono i kekahi mau solutes, e pili ana i ka hana o nā ʻāpana a me nā ʻōnaehana like ʻole.
Nīnau: He aha ke kahua aʻo e pili ana i kēia mau protein?
A: ʻO ke aʻo ʻana i nā protein membrane cell me kahi hana halihali e hāʻule i loko o ke kahua o ka biology cell a me ka biochemistry. Ke noiʻi nei ka poʻe ʻepekema i kēia mau mea lawe e hoʻomaopopo i ke ʻano o ka hoʻoponopono ʻia ʻana o kā lākou mau hana, ke ʻano o kā lākou localization i ka membrane a pehea e hiki ai ke hoʻohana ʻia i nā lāʻau lapaʻau e mālama i nā maʻi like ʻole.
Nīnau: Aia kekahi mau noiʻi e pili ana i kēia kumuhana?
A: ʻAe, ke hana ʻia nei ka nui o nā noiʻi ma ke kahua o nā protein membrane cell me kahi hana lawe. Ke ʻimi nei ka poʻe ʻepekema e hoʻomaopopo i ka kikoʻī i ka hana ʻana o kēia mau mea lawe a pehea e hoʻololi ʻia ai lākou i nā maʻi like ʻole. Eia kekahi, ke noiʻi ʻia nei ka hoʻomohala ʻana o nā lāʻau lapaʻau e hiki ke hoʻololi i ka hana o kēia mau protein i mea e mālama ai i nā maʻi e pili ana i nā hoʻololi ʻana i ka lawe ʻana i nā kelepona.
I ka hopena
I ka hōʻuluʻulu ʻana, he mea koʻikoʻi nā protein membrane cell me kahi hana transport i ka mālama ʻana i ke kaulike ionic a me ka molecular i loko o nā cell. ʻO kēia mau protein ke kuleana no ka hoʻoponopono ʻana i ka lawe ʻana i nā mea koʻikoʻi ma waena o ka membrane, e ʻae ana i ke komo ʻana a me ka puka ʻana o nā molekala koʻikoʻi no ka hana cellular.
Ma kēia ʻatikala holoʻokoʻa, ua ʻimi mākou i nā ʻano like ʻole o nā protein transport i loaʻa i loko o ka membrane cell, e hōʻike ana i kā lākou hana kikoʻī o ka hana a me ke koʻikoʻi o kā lākou hana pono. Mai nā awāwa ion e ʻae ai i ke ala koho o nā ion ma waena o ka membrane, i nā mea lawe e hoʻomaʻamaʻa i ka neʻe ʻana o nā molekala nui, hana pū kēia mau protein e mālama i ka homeostasis cellular.
Eia kekahi, ua kūkākūkā mākou i ka pili pono o nā protein membrane cell me kahi hana halihali, e hōʻike ana i ko lākou komo ʻana i nā maʻi like ʻole a me nā pilikia hiki ke alakaʻi i nā maʻi genetic, nā maʻi metabolic a me nā loli i ka lawe ʻana i ka lāʻau hoʻomaopopo pono i kona ʻano a me kāna hana.
I ka pōkole, ʻo nā protein membrane cell me kahi hana halihali he mau mea koʻikoʻi no ka hana pono o nā cell. ʻO kā lākou ākea ākea o nā hana a me kā lākou komo ʻana i nā maʻi e lilo lākou i kumuhana o ka pili ʻepekema a me ka pili kino. Ke holomua nei ka noiʻi ʻana i kēia mau protein, wehe ka puka i nā ʻike e hiki mai ana ʻaʻole hiki ke hoʻomaikaʻi wale i ko mākou ʻike ʻana i nā mīkini kelepona, akā hāʻawi pū kekahi i nā ala therapeutic hou no ka mālama ʻana i nā maʻi like ʻole.
ʻO wau ʻo Sebastián Vidal, he ʻenekinia kamepiula makemake nui i ka ʻenehana a me DIY. Eia kekahi, ʻo wau ka mea nāna i hana tecnobits.com, kahi aʻu e kaʻana like ai i nā kumu aʻo e hoʻomaʻamaʻa a hoʻomaopopo ʻia ka ʻenehana i nā mea a pau.