Cellular respiration yog txheej txheem tseem ceeb rau kev ua haujlwm zoo ntawm cov kab mob nyob. Los ntawm no complex series ntawm biochemical cov tshuaj tiv thaiv, hlwb tau txais lub zog nraaj coj txog nws cov haujlwm metabolic. Hauv kab lus no, peb yuav tshuaj xyuas kom meej Txoj kev no biological, los ntawm nws cov Cheebtsam mus rau nws cov theem tseem ceeb, nrog lub hom phiaj ntawm kev nkag siab tob npaum li cas cellular respiration tshwm sim thiab dab tsi nws tseem ceeb yog nyob rau hauv lub ciaj sia taus ntawm cov kab mob.
Introduction to Cellular Respiration : Saib Kom Paub Txog Cov Txheej Txheem Kev Ua Txhaum Cai
Kev ua pa ntawm tes yog ib qho tseem ceeb ntawm cov txheej txheem lom neeg uas cov hlwb tau txais lub zog los ntawm cov piam thaj thiab lwm cov organic compounds. Txawm hais tias cov txheej txheem no yog qhov tseem ceeb rau kev ua haujlwm ntawm txhua tus tsiaj nyob, nws tseem ceeb tshwj xeeb tshaj yog nyob rau hauv cov kab mob aerobic, cov uas xav tau oxygen kom ciaj sia.
Kev ua pa ntawm tes tau muab faib ua peb theem tseem ceeb: glycolysis, Krebs cycle thiab oxidative phosphorylation. Hauv glycolysis, qabzib tau tawg mus rau hauv me me molecules hu ua pyruvates, tsim ib qho me me ntawm lub zog hauv daim ntawv ntawm ATP. Lub voj voog Krebs txuas ntxiv mus kev tawg ntawm pyruvates, tso tawm ntau lub zog thiab tsim cov khoom sib txuas xws li NADH thiab FADH2 uas yuav nqa cov electrons mus rau theem kawg.Oxidative phosphorylation tshwm sim nyob rau hauv daim nyias nyias ntawm mitochondria y yog qhov kawg. theem ntawm cellular respiration. Ntawm no, cov khoom siv hluav taws xob nqa los ntawm NADH thiab FADH2 yog siv los tsim ib qho loj ntawm ATP los ntawm cov txheej txheem nyuaj hu ua electron thauj saw.
Cellular respiration yog ib txoj kev ua tau zoo heev uas tso cai rau cov kab mob mus tas li kom tau lub zog. Ntxiv nrog rau glycolysis, lub voj voog Krebs thiab oxidative phosphorylation, kuj tseem muaj lwm cov txheej txheem metabolic uas tuaj yeem ua rau lub zog tsim, xws li fermentation nyob rau hauv cov xwm txheej anaerobic. Kev nkag siab txog kev ua pa ntawm tes hauv kev nthuav dav yog qhov tseem ceeb rau kev nkag siab tias cov kab mob tau txais lub zog tsim nyog los ua lawv txoj haujlwm tseem ceeb thiab yog qhov tseem ceeb ntawm kev kawm hauv biology.
Lub voj voog Krebs: lub cav tseem ceeb ntawm kev ua pa ntawm tes
Lub voj voog Krebs, tseem hu ua lub voj voog citric acid lossis lub voj voog tricarboxylic acid, yog cov tshuaj biochemical uas tshwm sim hauv mitochondria, suav tias yog lub cav tseem ceeb ntawm kev ua pa ntawm tes. Lub voj voog no, nrhiav tau los ntawm Hans Krebs hauv xyoo 1937, yog qhov tseem ceeb rau kev tau txais lub zog hauv daim ntawv ntawm adenosine triphosphate (ATP).
Lub voj voog Krebs pib nrog acetyl-CoA molecule, uas yog tsim los ntawm degradation ntawm carbohydrates, lipids, thiab cov proteins. Cov molecule no tawg nyob rau hauv ib tug series ntawm cov tshuaj tiv thaiv, generating byproducts xws li carbon dioxide thiab txo cov tebchaw xws li NADH thiab FADH2 cov txo cov tebchaw nqa electrons los ntawm ntawm cov saw hlau Ua pa, tsim cov proton gradient uas nyob rau hauv lem tso cai rau cov synthesis ntawm ATP.
Lub voj voog Krebs muaj yim kauj ruam, txhua qhov catalyzed los ntawm ib qho enzyme tshwj xeeb. Cov enzymes no ua lub luag haujlwm tseem ceeb hauv kev tswj hwm thiab kev sib koom tes ntawm lub voj voog kev xav. Qee cov kauj ruam tseem ceeb suav nrog kev sib xyaw ntawm acetyl-CoA nrog oxyaloacetate los tsim citrate, oxidation ntawm citrate, thiab regeneration ntawm oxaloacetate. Raws li lub voj voog txuas ntxiv, cov nruab nrab tseem ceeb xws li succinate, fumarate, thiab malate raug tsim, uas koom nrog lwm txoj hauv kev metabolic.
Qhov tseem ceeb ntawm cov pa oxygen hauv cellular respiration: ib qho kev xav tsis thoob
Oxygen plays lub luag haujlwm tseem ceeb hauv kev ua pa ntawm tes, yog qhov tsim nyog rau txoj haujlwm no. txoj kev ua tau zoo. Los ntawm kev ua pa ntawm tes, cov hlwb tau txais lub zog tsim nyog los ua lawv txoj haujlwm tseem ceeb. Oxygen ua raws li qhov kawg receptor rau electrons tso tawm thaum lub sij hawm oxidative phosphorylation theem, tso cai rau zus tau tej cov adenosine triphosphate (ATP), lub ntsiab qhov chaw ntawm cellular zog.
Lub xub ntiag ntawm oxygen hauv cellular respiration tso cai kom tau txais ntau dua ntawm ATP ib cov piam thaj molecule piv rau anaerobic fermentation. Qhov sib txawv no nyob rau hauv lub peev xwm ntawm oxygen kom tau txais electrons thiab thauj lawv los ntawm cov kab mob ua pa, yog li tsim ib tug proton gradient uas tsav lub synthesis ntawm ATP nyob rau hauv lub puab mitochondrial membrane. Nyob rau hauv txoj kev no, oxygen dhau los ua ib qho tseem ceeb rau kev ua haujlwm zoo ntawm mitochondria thiab, yog li ntawd, ntawm tes ua pa tag nrho.
Ntxiv rau nws lub luag haujlwm hauv lub zog tsim tawm, oxygen tseem ua lub luag haujlwm tseem ceeb hauv cellular metabolism. Los ntawm kev koom tes hauv cov txheej txheem tseem ceeb xws li oxidation ntawm cov organic molecules, oxygen pab txhawb kev tshem tawm cov khoom pov tseg thiab kev sib txuas ntawm cov ntsiab lus tseem ceeb rau lub cell Ib yam li ntawd, oxygen ua raws li kev tswj hwm ntawm qee txoj hauv kev metabolic, tswj kev qhia ntawm cov noob ntsig txog. cov lus teb rau kev hloov pauv hauv ib puag ncig ib puag ncig. Hauv cov ntsiab lus, muaj cov pa oxygen hauv cellular respiration yog qhov tseem ceeb rau kev ua haujlwm kom raug thiab kev saib xyuas ntawm cellular homeostasis.
Electron thauj saw: lub ntsiab mechanism rau lub zog tsim
Cov saw hlau thauj electron yog ib txoj hauv kev yooj yim hauv cov txheej txheem ntawm lub zog ntawm tes. Cov saw no nyob rau hauv daim nyias nyias ntawm mitochondria, thiab nws lub hom phiaj tseem ceeb yog kev hloov ntawm electrons los ntawm cov proteins uas muaj nyob hauv nws. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias cov saw no yog tsim los ntawm plaub lub ntsiab protein complexes, hu ua I, II, III thiab IV, txhua tus nrog nws cov haujlwm tshwj xeeb hauv kev thauj khoom ntawm electrons.
Cov txheej txheem ntawm kev tsim hluav taws xob los ntawm cov saw hlau thauj hluav taws xob yog ua raws li kev hloov pauv ntawm cov khoom siv hluav taws xob los ntawm cov khoom siv hluav taws xob xws li NADH lossis FADH2 rau cov khoom siv hluav taws xob xws li oxygen. Qhov no ntws ntawm electrons generates ib tug electrochemical gradient hla lub puab mitochondrial membrane, hu ua lub peev xwm membrane. Lub peev xwm membrane no yog qhov tseem ceeb rau kev sib txuas ntawm ATP, cellular zog molecule par excellence.
Cov saw hlau thauj hluav taws xob tau ua tau los ntawm kev muaj cov cofactors, xws li coenzyme Q thiab cytochromes, uas ua lub luag haujlwm tseem ceeb hauv kev thauj cov electrons raws cov saw hlau. Tsis tas li ntawd, cov txheej txheem yog tswj hwm los ntawm tshwj xeeb inhibitors thiab activators, uas tso cai rau kev tswj hwm kev tswj hwm ntawm cov cellular zog ntau lawm. Hauv cov ntsiab lus, cov saw hlau thauj hluav taws xob yog qhov ua tau zoo heev rau kev tsim hluav taws xob, thiab nws txoj kev nkag siab yog qhov tseem ceeb rau kev nce qib hauv kev lag luam bioenergetics.
Mitochondria: qhov tseem ceeb rau kev ua pa ntawm tes
Cov kws tshawb fawb tau tshawb pom tias mitochondria ua lub luag haujlwm tseem ceeb hauv cov txheej txheem ntawm kev ua pa ntawm tes. Cov txheej txheem membranous, tam sim no nyob rau hauv tag nrho cov hlwb eukaryotic, suav hais tias yog "zog factories" ntawm peb lub cev. Nws lub luag haujlwm tseem ceeb yog tsim cov tshuaj adenosine triphosphate (ATP), cov molecule uas muaj zog tshaj plaws ntawm tes. Mitochondria yog qhov tseem ceeb rau kev tswj kom muaj zog sib npaug hauv peb cov hlwb.
Cov txheej txheem ntawm generating ATP los ntawm mitochondria, hu ua cellular respiration, yog complex thiab yuav siv sij hawm qhov chaw nyob rau hauv ntau theem, thawj theem tshwm sim nyob rau hauv lub txheej membrane ntawm lub mitochondria, qhov twg oxygen yog nkag. Cov pa oxygen ces mus rau mitochondrial matrix, ib yam khoom gelatinous nyob hauv mitochondria. Qhov no yog qhov chaw tseem ceeb ntawm kev ua pa ntawm tes, hu ua Krebs cycle, tshwm sim. Nyob rau hauv cov txheej txheem no, ATP precursor molecules yog generated uas yuav ces siv nyob rau theem tom ntej.
Qhov kawg theem ntawm cellular respiration tshwm sim nyob rau hauv lub mitochondrial cristae, uas yog folds nyob rau hauv lub puab membrane ntawm no organelle. Ntawm no, koj yuav pom cov electron thauj saw complex, uas yog lub luag hauj lwm rau hloov electrons los ntawm ib tug series ntawm cov proteins Raws li electrons txav raws cov saw no, protons raug tso tawm nyob rau hauv lub mitochondrial matrix. Cov protons yog siv los ntawm ATP synthase. tsim ATP los ntawm precursor molecules. Nyob rau hauv txoj kev no, mitochondria ua kom cov cellular ua pa thiab lub zog txaus rau kev ua haujlwm ntawm peb cov hlwb.
Kev tswj ntawm cellular ua pa: sib npaug thiab homeostasis
Kev tswj hwm ntawm cellular ua pa yog txheej txheem tseem ceeb rau kev tswj hwm qhov sib npaug thiab homeostasis hauv cov kab mob nyob. Los ntawm cov txheej txheem tswj hwm, cov hlwb tuaj yeem kho qhov nrawm thiab ua haujlwm ntawm kev ua pa raws li lub zog xav tau ntawm lub cev.
Ib qho ntawm cov kev tswj hwm tseem ceeb ntawm kev ua pa ntawm tes yog qhov concentration ntawm oxygen hauv ib puag ncig. Thaum cov pa oxygen txo qis, cov hlwb ua kom muaj cov txheej txheem biochemical kom hloov mus rau qhov xwm txheej no. Qhov no suav nrog cov kev cai ntawm kev qhia cov noob koom nrog hauv kev tsim cov enzymes ua pa thiab ua kom lwm txoj hauv kev metabolic kom tau txais lub zog.
Ntxiv nrog rau cov pa oxygen, lwm yam xws li carbon dioxide concentration thiab kub kuj tseem ua lub luag haujlwm tseem ceeb hauv kev tswj lub cev ua pa ntawm tes muaj cov txheej txheem los txheeb xyuas cov kev hloov pauv no thiab teb raws li, kom ua pa txaus thiab tso tawm lub zog tsim nyog. Hauv cov ntsiab lus, cov kev cai ntawm kev ua pa ntawm tes yog qhov tseem ceeb los tswj cov metabolism hauv kev sib npaug thiab homeostasis hauv cov kab mob hauv lub neej.
Kab mob thiab kev ua haujlwm tsis zoo cuam tshuam nrog kev ua pa ntawm tes: nkag siab txog qhov tshwm sim
Cellular respiration yog txheej txheem tseem ceeb hauv lub neej ntawm cov hlwb, qhov twg lub zog tau txais los ntawm cov piam thaj thiab lwm cov organic tebchaw. Txawm li cas los xij, thaum muaj kev ua haujlwm tsis zoo tshwm sim hauv cov txheej txheem no, cov kab mob thiab cov xwm txheej tuaj yeem tshwm sim uas cuam tshuam rau kev noj qab haus huv ntawm cov kab mob.
Qee yam kab mob ntsig txog kev ua pa ntawm tes muaj xws li:
- Mitochondrial tsis ua haujlwm: Thaum mitochondria, cov txheej txheem ntawm tes ua lub luag haujlwm rau kev ua pa ntawm tes, nthuav tawm kev ua haujlwm tsis zoo, nws tuaj yeem ua rau muaj kev hloov pauv loj hauv kev ua haujlwm ntawm ntau yam kabmob thiab cov ntaub so ntswg. Qhov no tuaj yeem pom nws tus kheej hauv cov tsos mob xws li cov leeg tsis muaj zog, mob nkees thiab teeb meem kev sib koom tes.
- Cov kab mob metabolic: Kev ua haujlwm tsis zoo hauv kev ua pa ntawm tes tuaj yeem hloov pauv cov khoom noj metabolism, ua rau cov kab mob xws li ntshav qab zib hom 2 thiab rog rog. Hauv cov xwm txheej no, cov hlwb tsis tuaj yeem siv cov piam thaj kom zoo, ua rau cov ntshav qab zib siab thiab teeb meem tswj lub cev hnyav.
- Cov kab mob neurodegenerative: Kev ua pa tsis zoo ntawm tes kuj tau cuam tshuam nrog cov kab mob xws li Alzheimer's, Parkinson's, thiab amyotrophic lateral sclerosis (ALS). Cov xwm txheej no yog tus cwj pwm los ntawm kev loj hlob ntawm cov paj hlwb thiab tuaj yeem ua rau tsis nco qab, kev paub tsis meej, thiab teeb meem kev txav mus los.
Hauv cov ntsiab lus, kev nkag siab txog qhov tshwm sim ntawm cov kab mob thiab kev ua haujlwm tsis zoo cuam tshuam nrog kev ua pa ntawm tes yog qhov tseem ceeb los txhim kho cov kev kho mob zoo thiab tiv thaiv cov teeb meem. Cov kev hloov pauv no tuaj yeem cuam tshuam tsis tsuas yog kev ua haujlwm ntawm tes, tab sis kuj tseem muaj kev noj qab haus huv tag nrho ntawm cov kab mob. Nws yog ib qho tsim nyog yuav tsum tau tshawb fawb txuas ntxiv kom tob peb txoj kev paub txog cov txheej txheem no thiab nrhiav txoj hauv kev tshiab los daws thiab kho cov kab mob no.
Cov lus pom zoo los txhim kho kev ua pa ntawm tes: kev txhawb nqa kev noj qab haus huv thiab kev noj haus
Kev ua pa ntawm tes yog ib qho txheej txheem tseem ceeb rau kev ua haujlwm ntawm peb lub cev, vim nws tso cai rau peb kom tau txais lub zog tsim nyog los ua txhua yam haujlwm tseem ceeb. Ntawm no peb nthuav qhia qee cov lus pom zoo los txhim kho cov txheej txheem no thiab txhawb kev noj qab haus huv ntawm tes:
Cov cwj pwm noj qab haus huv:
- Ua ib qho kev tawm dag zog lub cev tsis tu ncua. Kev ua lub cev ua rau cov ntshav ncig thiab txhawb nqa oxygenation ntawm cov hlwb.
- Pw tsaug zog zoo. Restorative so yog qhov tseem ceeb los tswj kom muaj qhov sib npaug ntawm cov metabolism hauv cellular.
- Zam kev ntxhov siab ntev. Kev ntxhov siab ntev tuaj yeem cuam tshuam tsis zoo rau cellular noj qab haus huv, yog li nrhiav cov tswv yim so kom pab txo qis.
Kev noj qab haus huv txhawb kev noj haus:
- Noj cov zaub mov uas muaj antioxidants, xws li txiv hmab txiv ntoo thiab zaub. Cov antioxidants no tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative thiab txhawb lawv txoj haujlwm kom raug.
- Xws li qhov chaw ntawm omega-3 fatty acids hauv koj cov zaub mov, xws li cov ntses rog, chia noob, los yog walnuts. Cov fatty acids no yog qhov tseem ceeb kom muaj kev ncaj ncees ntawm cov cell membranes.
- Xyuas kom koj tau txais cov vitamins thiab minerals txaus los ntawm kev noj zaub mov kom zoo. Cov zaub mov no yog qhov tseem ceeb rau cov txheej txheem metabolic ntawm cov hlwb.
Kev txhim kho cellular ua pa yog qhov tseem ceeb los txhawb kev noj qab haus huv thiab tiv thaiv kab mob. Los ntawm kev ua raws li cov lus pom zoo no thiab ua lub neej noj qab haus huv, koj yuav tuaj yeem ua kom zoo dua ntawm koj lub hlwb thiab txaus siab rau lub neej tag nrho thiab muaj zog.
Q&A
Lus Nug: Kev ua pa ntawm tes yog dab tsi?
Teb: Cellular ua pa yog ib qho txheej txheem metabolic uas tshwm sim hauv cov hlwb ntawm cov kab mob uas muaj sia nyob kom tau txais lub zog. Nws yog cov txheej txheem nyuaj uas cov as-ham, xws li qabzib, tau tawg nyob rau hauv lub xub ntiag ntawm oxygen los tsim ATP, lub ntsiab ntawm lub zog siv los ntawm cov hlwb.
Lus Nug: Cov theem ntawm cellular respiration yog dab tsi?
Teb: Cellular respiration muaj peb theem tseem ceeb: glycolysis, Krebs cycle thiab oxidative phosphorylation. Hauv glycolysis, qabzib tau muab faib ua ob lub pyruvate molecules, tsim ib qho me me ntawm ATP thiab NADH. Hauv lub voj voog Krebs, pyruvate tau tawg tag, tsim ntau ATP, NADH thiab FADH2. Thaum kawg, hauv oxidative phosphorylation, electrons nqa los ntawm NADH thiab FADH2 yog siv los ua ke ATP molecules.
Lus Nug: Qhov twg yog qhov ua pa ntawm tes ua pa tshwm sim?
Teb: Cellular respiration tshwm sim nyob rau hauv mitochondria, uas yog cellular organelles lub luag hauj lwm rau lub zog tsim. Cov enzymes tsim nyog rau ntau theem ntawm kev ua pa ntawm tes yog nyob rau hauv daim nyias nyias ntawm mitochondria.
Lus Nug: Dab tsi yog qhov tseem ceeb ntawm kev ua pa ntawm tes?
Teb: Kev ua pa ntawm tes yog qhov tseem ceeb rau kev ciaj sia ntawm cov kab mob nyob, vim nws muab lub zog tsim nyog los ua kom tag nrho cov haujlwm ntawm tes. Tsis tas li ntawd, kev ua pa ntawm tes yog cov txheej txheem ua kom muaj txiaj ntsig zoo rau kev tsim ATP, tso cai rau cov hlwb kom muaj homeostasis thiab ua haujlwm tseem ceeb, xws li kev loj hlob, kev tsim cov protein, thiab DNA replication.
Lus Nug: Yuav ua li cas yog tias tsis muaj oxygen txaus rau kev ua pa ntawm tes?
Teb: Thaum tsis muaj oxygen, aerobic cellular ua pa tsis tuaj yeem tshwm sim. Raws li cov xwm txheej no, cov hlwb tuaj yeem hloov mus rau ib hom kev ua pa hu ua anaerobic cellular respiration lossis fermentation, uas tsis tshua muaj txiaj ntsig thiab ua rau ATP tsawg dua. Txawm li cas los xij, nyob rau hauv ntau yam kab mob xws li tib neeg, qhov tsis muaj oxygen rau lub sijhawm ntev tuaj yeem ua rau muaj kev puas tsuaj ntawm tes thiab, hauv qhov xwm txheej hnyav, ua rau lub cev tuag.
Txoj kev ua raws
Hauv cov ntsiab lus, kev ua pa ntawm tes yog qhov txheej txheem tseem ceeb rau lub neej ntawm cov hlwb. Los ntawm cov tshuaj biochemical complex, cov hlwb tau txais lub zog tsim nyog los ua lawv cov haujlwm tseem ceeb. Cov txheej txheem muaj peb theem: glycolysis, Krebs cycle thiab cov kab ua pa. Txhua theem no yog ib qho tseem ceeb los xyuas kom meej qhov khoom noj tas li ntawm ATP, lub cell roj.
Kev ua pa ntawm tes yog ib txoj hauv kev ua tau zoo thiab tswj hwm uas tso cai rau cov hlwb kom tau txais lub zog tsim nyog los ua txhua yam lawv ua. Thaum peb ua tiav peb txoj kev nkag siab ntawm cov txheej txheem no, peb tuaj yeem ua kom zoo dua koj daim ntawv thov nyob rau hauv txawv teb, xws li tshuaj thiab biotechnology.
Hauv kev xaus, kev ua pa ntawm tes yog ib qho txheej txheem tshwj xeeb heev thiab tseem ceeb heev rau kev ua haujlwm ntawm cov hlwb. Los ntawm degradation ntawm cov as-ham, hlwb tau txais lub zog tsim nyog rau lawv txoj sia nyob thiab ua haujlwm. Cov txheej txheem no, txawm hais tias nyuaj, ua kom pom lub peev xwm zoo rau kev hloov kho thiab kev ua haujlwm ntawm cov hlwb los lav lawv tus kheej lub neej. Txoj kev tshawb fawb txuas ntxiv ntawm kev ua pa ntawm tes ua rau peb nkag siab tob txog seb cov tsiaj nyob li cas tswj thiab ua haujlwm.
Kuv yog Sebastián Vidal, tus kws kho tshuab computer mob siab rau kev siv tshuab thiab DIY. Tsis tas li ntawd, kuv yog tus tsim tecnobits.com, qhov twg kuv qhia cov lus qhia ua kom siv thev naus laus zis ntau dua thiab nkag siab rau txhua tus.