- Chithandizo chokhala ndi ma nanoparticles a bioactive chimagwira chotchinga chamagazi-muubongo osati mwachindunji pamanyuroni.
- Mu zitsanzo za mbewa, kuchepa kwa 50-60% kwa amyloid kunapindula panthawi ya jekeseni ndi kusintha kwa chidziwitso pambuyo pa katatu.
- Tinthu tating'onoting'ono timatsanzira LRP1 ligands, kubwezeretsanso njira yovomerezeka yachilengedwe, ndikulimbikitsa kuchotsa Aβ m'magazi.
- Njirayi, yofalitsidwa mu Signal Transduction and Targeted Therapy, ikulonjeza koma ikufunabe mayesero aumunthu.
Un timu yapadziko lonse lapansi, ndi utsogoleri wochokera ku Institute of Bioengineering of Catalonia (IBEC) ndi Chipatala cha West China cha Sichuan University, yapereka njira ya nanotechnology yomwe amasintha zizindikiro za Alzheimer's mu mbewa pokonza chotchinga magazi muubongo (BBB). Kunena monse, izo ziri pafupi gwiritsani ntchito ma nanoparticles omwe amakhala ngati mankhwala okha kubwezeretsa ntchito ya ubongo.
Kusintha kumeneku kumamveka bwino ngati tikumbukira izi ubongo umadya pafupifupi 20% ya mphamvu mwa akuluakulu ndi a 60% mwa ana, mothandizidwa ndi maukonde okhuthala a ma capillaries pomwe neuroni iliyonse imalandira chithandizo. BBB ikasinthidwa, njira yotayira zinyalala imavutika ndipo imakonda kudzikundikira kwa beta amyloid (Aβ), chizindikiro cha matenda.Akuti ubongo wa munthu uli ndi ma capillaries pafupifupi biliyoni imodzi, chifukwa chake kufunika kwa thanzi la mitsempha.
Kodi njira ya nanotechnology iyi ikufuna chiyani?
Mosiyana ndi classical nanomedicine, yomwe imagwiritsa ntchito nanoparticles ngati magalimoto wamba, njira iyi imagwiritsa ntchito supramolecular mankhwala omwe ali bioactive ndipo safuna kunyamula mfundo ina. Cholinga chake si neuron, koma BBB ngati chandamale cha achire.
Mumikhalidwe yabwinobwino, Cholandilira cha LRP1 chimazindikira Aβ ndikuchisamutsa kudutsa chotchinga kupita m'magaziKomabe, ndondomekoyi ndi yovuta: Ngati kumangako kuli kochulukira kapena kosakwanira, zoyendera ndizosakhazikika ndipo Aβ imawunjikana. Ma nanoparticles opangidwa kutsanzira LRP1 ligands kuti ndipezenso bwino.
Ndi kuchitapo kanthu, njira yotuluka ya mapuloteni ovuta kuchokera ku parenchyma m'magazi, kulimbikitsa Aβ chilolezo ndi normalizing chotchinga ntchito. Mwachidule, izo reactivates ndi njira yoyeretsera zachilengedwe wa ubongo.
Kuyesa kwachitsanzo cha zinyama ndi zotsatira
Kuwunikaku kunachitika pa mbewa zosinthidwa kuti zipangitse kuchuluka kwa Aβ ndikupanga kuwonongeka kwa chidziwitso. Ma jakisoni atatu a tinthu tating'onoting'onowa anali okwanira kuwona kusintha koyezeka kwa ma biomarker ndi machitidwe..
Malinga ndi olembawo, ola limodzi lokha pambuyo pa utsogoleri Kuchepa kwa 50-60% mu Aβ mu ubongo kwalembedwa kaleKuthamanga kwa zotsatira kumasonyeza kukonzanso mwamsanga kwa kayendedwe ka kayendetsedwe kake kudutsa chotchinga.
Kupitilira zomwe zimachitika posachedwa, zotsatira zokhalitsa zimafotokozedwa. Pakuyesa kumodzi, mbewa ya miyezi 12 idawunikidwanso pa miyezi 18 ndikuwonetsa. ntchito yofanana ndi ya nyama yathanzi, kusonyeza kuchira kokhazikika pambuyo pa chithandizo.
Gululo limatanthauzira kuti pali a unyolo zotsatira: pobwezeretsa ntchito ya mtima, Kutulutsidwa kwa Aβ ndi mamolekyu ena owopsa kumayambiranso, ndipo dongosololi limayambiranso.. M'mawu a utsogoleri wa sayansi, tinthu tating'onoting'ono timakhala ngati mankhwala omwe imayambitsanso njira yochotsera mpaka mulingo wabwinobwino.
Akatswiri akunja amafotokoza kuti zomwe zapezedwazo zimalonjeza, ngakhale akuwonetsa kuti zotsatira zake zapezedwa m'mafanizo a murine ndipo kumasulira kumeneko kwa odwala kumafuna kusamala. Anthu ammudzi akugogomezera kufunikira kotsimikizira chitetezo ndi mphamvu mwa anthu omwe ali ndi maphunziro okhwima.
Mapangidwe a mamolekyu kumbuyo kwa nanoparticles
Ma nanoparticles awa amapangidwa ndi njira ya uinjiniya wa mamolekyulu apansi mmwamba, kuphatikiza kukula kolamulidwa ndi a chiwerengero cha ligands pamwamba pake kuti agwirizane ndi zolandilira mwanjira inayake.
Pa modulating ndi receptor traffic mu membrane, Tinthu tating'onoting'ono timakonza njira yosinthira Aβ kudutsa BBBDigiri yolondola iyi imatsegula njira sinthani ntchito za receptor zomwe mpaka pano zinali zovuta kuziwongolera mwachirengedwe.
Chifukwa chake, sikuti kungochotsa bwino kwa Aβ kumalimbikitsidwa, koma Zimathandizira kusinthasintha kwamphamvu kwa mitsempha yomwe imathandizira kugwira ntchito kwaubongo.. Uku ndiye kusiyana kwakukulu kuchokera ku njira zomwe zimangokhalapo perekani mankhwala.
Ndani akutenga nawo mbali ndipo chotsatira ndi chiyani?
Consortium imabweretsa pamodzi IBEC, Chipatala cha West China ndi Xiamen West China Hospital ku Sichuan University, ndi University College ku LondonLa Universidad de Barcelona, ICREA, ndi Chinese Academy of Medical Sciences, pakati pa ena. Zomwe zapezazo zasindikizidwa m'magazini Kusindikiza Kwa Chizindikiro ndi Chithandizo Cholimbana.
Polingalira za kumasulirako, ulendo womveka umadutsa zizindikiro zopanda pake, Maphunziro a Toxicological, kusanthula kwa mlingo ndi, ngati kuli koyenera, mayesero a anthu a gawo la I/IIChitetezo ndi kuberekana zidzakhala zofunikira kuti tipite patsogolo.
Kupitilira Alzheimer's, ntchitoyi imayang'ana kwambiri thanzi la cerebrovascular monga chinthu chachikulu cha dementia, kutsegula gawo lachirengedwe lomwe likugwirizana ndi njira zama neuron-centered classical.
Deta akusonyeza kuti kulowerera pa magazi-ubongo chotchinga ndi bioactive nanoparticles imatha kuchepetsa msanga katundu wa amyloid, kubwezeretsa ntchito ya mitsempha, ndikusintha zotsatira za chidziwitso mu mbewa; njira yodalirika yomwe, mosamala, iyenera kutsimikiziridwa maphunziro azachipatala zopangidwa bwino.
Ndine wokonda zaukadaulo yemwe wasandutsa zokonda zake za "geek" kukhala ntchito. Ndakhala zaka zoposa 10 za moyo wanga ndikugwiritsa ntchito ukadaulo wotsogola komanso kusewera ndi mitundu yonse yamapulogalamu chifukwa cha chidwi chenicheni. Panopa ndaphunzira luso la pakompyuta komanso masewera a pakompyuta. Izi zili choncho chifukwa kwa zaka zoposa 5 ndakhala ndikulembera mawebusaiti osiyanasiyana pa teknoloji ndi masewera a pakompyuta, ndikupanga nkhani zomwe zimafuna kukupatsani zambiri zomwe mukufunikira m'chinenero chomwe chimamveka kwa aliyense.
Ngati muli ndi mafunso, chidziwitso changa chimachokera ku chilichonse chokhudzana ndi makina opangira Windows komanso Android pama foni am'manja. Ndipo kudzipereka kwanga ndi kwa inu, nthawi zonse ndimakhala wokonzeka kuthera mphindi zochepa ndikukuthandizani kuthetsa mafunso aliwonse omwe mungakhale nawo pa intaneti.