Muchidzidzo che cell biology, kudzokorodza kwecentriole kunoita basa rakakosha. musero kutendereraCentrioles zvimiro zvecylindrical zvinowanikwa mu cytoplasm yesero uye kuve nemabasa akawanda, kusanganisira kuronga mitotic spindle panguva yekukamurwa kwesero. Muchinyorwa ichi chese, maitiro ekudzokorodza kwecentriole achaongororwa nehunyanzvi, achitsanangura zviitiko zvakakosha zvinoitika panguva yega yega. ye cell cycleKushandisa nzira isina kwayakarerekera, iyo yakaoma uye nzira dzinobatanidzwa muiyi nzira yakakosha yekuvandudza nekuchengetedza genetic kuvimbika kwemasero kuchaongororwa.
1. Tsanangudzo uye mabasa akakosha e centrioles musero cycle
Centrioles zvimiro zvecylindrical zviripo mumasero eukaryotic anoita basa rakakosha kutenderera kweseroAya organelles, anoumbwa nepfumbamwe microtubule katatu, ari mu cytoplasm padyo nesero nucleus. Basa ravo guru ndere kutora chikamu mukuumbwa kwemitotic spindle panguva yekupatsanurwa kwesero, kuve nechokwadi chekugovera kwakaringana kwemakromosomes pakati pemwanasikana maseru.
Pamusoro pebasa ravo mukukamura maseru, centrioles anewo mamwe mabasa akakosha mukati kutenderera kwesero. A continuación, se detallan algunas de ellas:
- Sangano re cytoskeleton: Centrioles inobatanidzwa mukuumbwa uye kurongeka kwemaitiro ekutsigira intracellular, zvakadai se microtubules uye actin filaments. Izvi zvikamu zvakakosha pakuchengetedza sero chimiro uye simba, pamwe nekufambisa kufamba kwemasero.
- Kuumbwa kwe cilia uye flagella: Mune mamwe marudzi esero, centrioles inoshanda senzvimbo dzekuronga dze cilia uye flagella. Izvi zvimiro zvine basa rekufamba kwesero kana kugadzira extracellular fluid mafambiro, achiita basa rakakosha mukutorwa kwezvikafu, kubereka, uye kutakura zvinhu.
- Cell cycle control: Centrioles inobatanidzwawo mune sero cycle regulation. Kudzokorodza kwavo uye kupatsanurwa kwave kucherechedzwa kuve kwakanyatso kudzorwa mukati mezvikamu zvakasiyana zvesero kutenderera, kuve nechokwadi chekuti sero rinopatsanurwa nemazvo uye rinochengeta kwakaringana cellular architecture.
Muchidimbu, macentrioles anotamba mabasa akakosha musero kutenderera, kutora chikamu mumitotic spindle formation, cytoskeletal organisation, cilia uye flagella kuumbwa, uye sero cycle control. Basa ravo chairo rakakosha pakupatsanurwa kwesero uye kuchengetedza kuvimbika uye kushanda kwemasero eukaryotic.
2. Chimiro uye kuumbwa kwe centrioles: mabhesi ekudzokorora
Chimiro che centrioles chakakosha pakuita kwavo mukudzokororwa kwesero. Centrioles zvimiro zvecylindrical zvinoumbwa nemapfumbamwe microtubule katatu, akarongwa mu radial array. Imwe neimwe katatu inoumbwa nematatu ega ega microtubules, imwe pakati uye maviri kumagumo. Iyi microtubule kurongeka kunopa centrioles hunhu hwayo dhiramu chimiro.
Centrioles inoumbwa nemapuroteni akati wandei. Imwe yeiyi ndeye centrin, puroteni yemaitiro inowanikwa pamakona e microtubule mukati me centrioles. Imwe puroteni yakakosha ndeye tubulin, iyo inoumba katatu microtubules. Mukuwedzera, mamwe mapuroteni ekutonga aripo anodzora kudzokorora centriole uye basa.
Centriole kudzokorora inzira chaiyo uye inodzorwa. Inotanga nekuumbwa kwecentriole itsva kubva kune iripo. Panguva yekudzokorora, ma microtubules evatatu vanogadzirisa zvakare uye vanogadzira seti nyowani yematatu matatu, anonamatira kune yekutanga centriole. Kuita uku kunoita kuti sero remwanasikana rive nemacentrioles anodiwa kuita kupatsanurwa kwesero kwakaringana. Nekudaro, chimiro uye kuumbwa kwe centrioles kwakakosha pakudzokorora kwavo kwakaringana uye kushanda musero kutenderera.
3. Kudzora kwe centriole replication panguva yesero kutenderera
Centriole replication panguva yesero kutenderera inodzorwa zvakasimba kuti ive nechokwadi chekupatsanurwa kwesero uye kuumbwa kwecilia uye flagella. Iyi nzira yakakosha pakuona kugadzikana kwegenome uye kwakaringana sero basa.
Kudzorwa kwe centriole kudzokororwa kunosanganisira nhevedzano yeakaoma mamolekyulu maitiro. Chekutanga, chiitiko checyclin-dependent kinase 2 (CDK2) chinodiwa kuti cell cycle kufambira mberi uye, nekudaro, ye centriole replication. Uyezve, kuunganidzwa kweprotein inonzi Orc1 mu centrioles inodzora kutangwa kwekudzokorora, nepo protein yeCPAP inoronga kureba kwecentriole.
Chimwe chinhu chakakosha mukutonga kwe centriole kudzokorora chiito cheDNA kutendeseka chekutarisa macomplexes, senge p53 protein. Aya macomplexes anovimbisa kuti kudzokorora kweDNA kwakazara uye hakuna kukanganisa kusati kwatanga kuumbwa kwecentriole. Uyezve, kana macentrioles adzokorora, puroteni yePLK4 inoita basa rakakosha mukuumbwa kwakakodzera kwemwanasikana centrioles, kutonga nhamba yavo uye chinzvimbo.
4. Kukosha kwekunyatso dzokorora centriole mukupatsanurwa kwesero
Kunyatso dzokorora kwema centrioles panguva yekukamura nharembozha inzira Yakakosha pakuona kwakaringana chromosome segregation uye kwakaringana mitotic spindle kuumbwa. Centrioles zvimiro zvecylindrical zvinoumbwa zvakanyanya zveprotein matrix uye zvakakosha pakuumbwa kwekinetochores uye spindle microtubules. Uku kudhindwa chaiko kwakakosha pakuchengetedza genome kuvimbika uye kudzivirira chromosomal abnormalities.
Chimwe chezvikonzero chikuru nei kudzokorora kwecentriole kwakakosha ibasa rayo rakakosha mukuumbwa kwemitotic spindle. Munguva yekupatsanurwa kwesero, iyo mitotic spindle mafomu kubva kunyukireya microtubules, uye centrioles inoita basa rakakosha musangano iri. Kurongeka kwecentriole kwakaringana kunovimbisa kuti mwanasikana wega wega sero rinogashira kopi chaiyo yemitotic spindle, zvichibvumira kugovera kwechromosome kwakaringana uye kudzivirira kukanganisa mukuparadzaniswa kwesero.
Uyezve, iyo chaiyo dhizaini ye centrioles inoitawo basa rakakosha mukudzora sero kutenderera. Centrioles inobatanidzwa mukugadzirisa kufambira mberi kwesero, kunyanya mukuchinja kubva kuG1 chikamu kusvika kuS chikamu, apo centriole kudzokorora uye kupatsanurwa kunoitika. Kuita uku kunoita kuti sero remwanasikana rive nenhamba chaiyo yemacentrioles kuita basa rayo. mabasa ayo yakakosha mukukamura maseru. Dysregulation ye centriole duplication inogona kutungamira kune cell cycle abnormalities uye kukurudzira kukura kwezvirwere zvakaita segomarara.
5. Basa rakakosha rekudzokororwa centrioles mu mitotic spindle formation
Yakadzokororwa centrioles inoita basa rakakosha mukuumbwa kwemitotic spindle, ichikosha pakupatsanura kwakaringana kwemakromosome panguva yekukamurwa kwesero. Pazasi, zvimwe zve mabasa akakosha kuti aya organelles anotamba mukuita uku:
Sangano re mitotic spindle: Replicated centrioles anoita senyucleated kuronga zvimiro, achigadzira mapango emitotic spindle. Aya mapango akakosha pakuona axis yekukamura maseru uye kutungamira kupatsanurwa kwakaringana kwemakromosomes. Uyezve, centrioles yakadzokororwa inobatanidzwawo mukuumbwa kwema microtubules, ayo anokosha kune sangano rakakodzera remitotic spindle.
Chizvarwa che traction forces: Munguva ye mitosis, macentriole akadzokororwa anobatsira mukugadzirwa kwemasimba ekukweva anobvumira kupatsanurwa kwakaringana kwemakromosome akananga kumatanda ekuruka. Kuburikidza nekudyidzana pakati pe microtubules nucleated ne centrioles uye chromosomes, iyo yakaoma nzira inogonesa kugoverwa kwakaenzana kweiyo genetic zvinhu mumwanasikana wega wega cell inogadzirwa.
Regulation ye cell cycle: Replicated centrioles inobatanidzwawo musero cycle regulation, kubatsira kuona nekugadzirisa zvikanganiso panguva ye mitosis. Kana DNA isina kudzokorodza nemazvo kana kukuvadzwa kwemajini kwakaitika, akadzokororwa macentrioles anogona kushandura masiginecha nzira dzinomisa kupatsanurwa kwesero uye kubvumidza kugadziriswa kwezvakakanganisika genetic zvinhu.
6. Zvinokonzerwa nekuregererwa kwe centriole replication muzvirwere zvemajini
Kudzokororwa kudzokororwa kwema centrioles, madiki madiki masero akakosha kune mitotic spindle kuumbwa uye cytoskeletal organisation, yakabatanidzwa mukukura kwezvirwere zvakasiyana siyana zvemajini. Izvi zvinorehwa zvakakosha zvikuru mukudzidza kwepathologies inokanganisa kushanda kwakanaka kwesero kutenderera uye inogona kuvhura nzira nyowani dzekurapa.
Chimwe chezvirwere zvakakura zvemajini zvine chekuita nekudzoreredzwa kwecentriole ndeyekutanga autosomal recessive microcephaly (PRMM). Vanhu vanobatwa nechirwere ichi vanoona kudzikira kwakanyanya muhukuru hwehuropi nekuda kwekusakwana kugadzirwa kwe precursor neurons. Zvidzidzo zvenguva pfupi yapfuura zvakaratidza kuti kuvharidzira kudzokorora kwecentriole kungave iri nzira inovimbisa yekurapa yekurapa microcephaly.
Chimwe chirwere chemajini chinosanganiswa nekusadzora centriole kudzokorora ndeye Meckel-Gruber syndrome (MG). Chirwere ichi chinoratidzwa nekukanganisika kwakanyanya kwe "fetus", senge renal cysts, polydactyly, uye kukanganisa mukuumbwa kwecentriole. yetsinga Central. Tsvagiridzo mumhando dzemhuka yakaratidza kuti kushandura centriole kudzokorora maitiro kunogona kudzivirira kuvandudzwa kwemamiriro ane chekuita neMeckel-Gruber syndrome, ichipa inogona kurapa mhinduro yechirwere ichi.
7. Zvishandiso uye matekiniki ekudzidza kwakadzama kwe centriole replication
Muchidzidzo chakadzama chekudzokorodza kwecentriole, maturusi akati wandei uye matekiniki akakosha kuti uwane mhedzisiro uye yakavimbika mhedzisiro. Pazasi, tichatsanangura zvimwe zvezvishandiso izvi uye matekiniki anoshandiswa mukutsvaga kwesainzi.
1. Super-resolution microscopy: Iyi nzira inobvumira kufungidzira kwepamusoro-soro ye centrioles uye maitiro avo akabatanidzwa. Kushandiswa kwemaikorosikopu epamusoro-soro, senge focal point structure fluorescence microscopy (dSTORM) kana stimulated emission microscopy (STED), inobvumira kuratidzwa kwakadzama kwematanho akasiyana e centriole kudzokorora.
2. Immunofluorescent staining: Kushandisa chaiwo masoja ekudzivirira chirwere, zvikamu zvakasiyana-siyana zve centrioles zvinogona kunyorwa uye nzvimbo yavo uye kugovera kunoonekwa panguva yekudzokorora. Iyi nzira inoshandiswa zvakanyanya kuona mapuroteni akakosha anosanganisirwa mukudzokorodza kwecentriole uye kudzidza maitiro avo epakati uye enguva.
3. Genetic manipulation: Genetic manipulation techniques, yakadai seRNA interference (RNAi) uye CRISPR / Cas9 gene editing, inotibvumira kudzidza mhedzisiro yekudzivisa kana kugadzirisa maitiro chaiwo pakudzokorora kwe centriole. Zvishandiso izvi zvinogonesa kucherechedzwa kwemamorekuru zvinosanganisirwa mukudzokorodza mutemo uye zvinopa ruzivo rwakakosha mumagadzirirwo ari pasi.
8. Kufambira mberi kwazvino mukunzwisisa kwedu kwecentriole cell cycle regulation
Tsvagiridzo yesainzi mukutonga kwesero kutenderera ne centrioles yakaona kufambira mberi kukuru mumakore achangopfuura. Aya ma cylindrical microbodies anoita basa rakakosha mukupatsanurwa kwesero uye kuumbwa kwe cytoskeleton, asi mutemo wavo wakadzama unoramba uchinetsa kune vesainzi. Kuburikidza nezvidzidzo zvakaomarara uye matekinoroji epamberi, zvakakosha zvakawanikwa zvakawanikwa izvo zvinopa chiedza pane yakaoma kudzora michina inotonga kutenderera kweiyi organelles.
Chinonyanya kukosha chekufambira mberi uku ndiko kuzivikanwa kwemapuroteni akakosha ekudzora mucentriole cell cycle. Mapuroteni aya, akadai Polo-kunge kinase 1 (PLK1) uye NIMA-inoenderana kinase 2 (NEK2) yakaratidzwa kupesvedzera zvakanyanya centriole kudzokorora, kupatsanura, uye kukura. Nekudaro, akawanda masigning michina, senge Fndc-1/Nac1-Cep57-DYNLRB2-PLK1, kutora chikamu mukushanda kwakarurama kwe centrioles uye, naizvozvo, mukugadzirisa kwakarurama kwesero cycle.
Imwe nzvimbo yekufarira ichangoburwa ndeye kutonga kwakashata kwesero kutenderera ne centrioles. Zvakaonekwa kuti mamwe mapuroteni, akadai BRCA1 y BRCA2, ita sevanodzvinyirira bundu nekudzivisa kusingadzoreki kuwedzera kwe centriole. Uyezve, kuzivikanwa kweanosarudza protein kinase inhibitors, kunyanya kunanga centriole-inotonga enzymes, yakavhura mitsva yekurapa horizons mumunda wegomarara nezvimwe zvirwere zvinoenderana.
9. Nzira dzinogona kuitika dzekurapa dzakanangana necentriole replication abnormalities
Pane akati wandei nzira dzekugadzirisa centriole replication abnormalities, izvo zvinogona kubatsira kugadzira kurapa kunoshanda kune aya mamiriro. Mamwe emazano aya anoratidzwa pazasi:
Pharmacological inhibition: Mishonga yemakemikari yakaonekwa iyo inogona kurambidza zvakananga kudzokorora centriole. Mishonga iyi inogona kushandiswa senzira dzakanangwa dzekurapa kudzivirira kuumbwa kwemacentrioles asina kukwana. Uyezve, inhibition yemishonga inogonawo kukurudzira kuderedzwa kwemacentrioles aripo, izvo zvingabatsira kuderedza maitiro avo pamaseru.
Genetic correction: Imwe nzira inogona kuve iyo genetic kururamisa kwecentriole replication abnormalities. Izvi zvinogona kuwanikwa kuburikidza nematekinoroji akadai sekugadzirisa magene kana kurapwa kwemajini. Semuyenzaniso, nekuisa jena chairo, iyo yakajairika centriole kudzokorora maitiro inogona kudzoreredzwa uye mhedzisiro yakaipa ine chekuita nekusagadzikana yakaderedzwa.
Kukurudzira kwe centriole kugadzikana: Izvo zvakare zvinokwanisika kugadzira marapirwo ane chinangwa chekusimbisa centriole kugadzikana, izvo zvinogona kudzivirira kuumbwa kweabnormal centrioles. Izvi zvinogona kuwanikwa nekukurudzira kusaina nzira dzakabatanidzwa mukuchengetedza centriole uye kudzora. Zvidzidzo zvenguva pfupi yapfuura zvakaratidza zvimwe zvinhu zvakakosha zvingave zvinangwa zvekurapa zvekuvandudza centriole kugadzikana uye kudzivirira maseru kubva kune anokanganisa akabatana.
10. Nhepfenyuro dzemangwana: matambudziko nemikana mukudzidza kwe centriole cycle
Kudzidza kwe centriole cycle kwakapa nzwisiso yakakosha mu cell biology nemabatiro ayo pakukura nekushanda kwezvipenyu. Nekudaro, matambudziko mazhinji nemikana yasara kudzamisa kunzwisisa kwedu kweiyi nzira yakakosha. Pazasi pane mamwe mafambiro ekutsvagisa ayo anogona kupa akazara maonero eiyo centriole kutenderera:
- Centriole-sero kusangana: Kuongorora kudyidzana pakati pe centrioles uye zvimwe zvikamu zvemasero kwakakosha kuti unzwisise kuti zvinodzorwa uye kurongeka sei panguva yesero kutenderera. Kunzwisisa kuri nani kwekuti ma centrioles anodyidzana sei ne membrane-akabatanidzwa mapuroteni, cell organelles, uye zvimwe cytoskeletal zvinhu zvinodiwa.
- Molecular control ye centriole cycle: Kuziva nzira dzemamorekuru dzinoronga centriole kutanga, kudzokorora, kupatsanurwa, uye kutama idambudziko guru. Tsvagiridzo mumapuroteni anodzora, kusaina macascades, uye zvinyorwa zvinyorwa zvinosanganisirwa muchikamu chimwe nechimwe chekutenderera kunodiwa kuti unzwisise zviri nani kuti centriole kutendeseka kunodzorwa uye kuchengetedzwa sei.
- Clinical zvinoreva: Kuongorora mhedzisiro yekiriniki yekukanganisa mu centriole cycle inzvimbo inovimbisa. Kuchinja kwechiitiko ichi kwakaratidzwa kuve kwakabatana nezvirwere zvemajini uye kusagadzikana kwekukura, seMeckel-Gruber syndrome uye primary ciliary dyskinesia. Kuongorora masangano aya kunogona kuvhura nzira nyowani dzekuongororwa uye kurapwa kwezvirwere zvevanhu.
Muchidimbu, kudzidza kwecentriole kutenderera kunopa nzvimbo yakakura yekutsvagisa ine matambudziko anonakidza nemikana yekuwedzera kunzwisisa kwedu kwesero biology. Tsvagiridzo yeramangwana inofanira kutarisa nezve centriole-sero kudyidzana, kudzora mamorekuru, uye zvekiriniki zvinokonzeresa kuti uenderere mberi nekufambisira mberi iyi inonakidza ndima uye kushandisa kugona kwayo kuvandudza hutano hwevanhu.
11. Hunhu uye zvemutemo kufunga mune centriole replication research
Kufunga nezvetsika:
Centriole kudzokorora tsvakiridzo inoisa akati wandei matambudziko ehunhu ayo anofanirwa kunyatso tariswa. Chekutanga, zvakakosha kuve nechokwadi chemvumo ine ruzivo kubva kune vatori vechikamu mune chero chidzidzo chinosanganisira kuunganidzwa kwemasero ecentriole samples. Izvi zvinosanganisira kupa tsananguro yakajeka yezvinangwa zvechidzidzo, zvingangobatsira nenjodzi, nekuona kuvanzika kwedata rakaunganidzwa.
Uyezve, zvakakosha kuve nechokwadi chekugara zvakanaka uye kurapwa kwevanhu kwezvipenyu zvinoshandiswa mukutsvaga. Centrioles anowanikwa mumhando dzakasiyana-siyana dzezvipenyu, kubva kumasero tsika kusvika kuenzanisi zvipenyu zvakaita sembeva uye nematodes. Naizvozvo, zvakakosha kutevedzera nhungamiro yetsika yakasimbiswa yekushandiswa kwemhuka uye zvipenyu mukutsvagisa kwesainzi, kuve nechokwadi chekutarisira kwavo kwakanaka uye kuderedza kutambura kupi zvako kusingakoshi.
Zvaunofanira Kufunga Nezvemutemo:
Nezvekutariswa kwemutemo, centriole kudzokorora kutsvagisa kunofanirwa kutevedzera zvese zvinoshanda zvemuno nepasirese mirau nemitemo. Izvi zvinosanganisira kuwana mvumo nemvumo dzose dzinodiwa usati waita chidzidzo chipi nechipi. Zvinonyanya kukosha kuve nechokwadi chekuteedzera mitemo yekudzivirira data paunenge uchiunganidza uye uchishandisa maseru masampuli kubva kuvanhu, kuve nechokwadi kuti zvakavanzika uye zvakavanzika de la información recopilada.
Uyezve, zvakakosha kuremekedza mitemo yezvivakwa zveuchenjeri uye kodzero dzekopi paunenge uchishandisa chero mhedzisiro kana ruzivo rwakawanikwa kubva mukutsvagisa. Izvi zvinosanganisira kudoma nemazvo vanyori vezvakawanikwa uye kuziva chero patents kana mamwe kodzero yepfuma yeruzivo inogona kuenderana nekudzokorora kwecentriole. Aya mafungiro emutemo anobatsira pakutendeseka uye kubuda pachena kwetsvakiridzo yesainzi.
12. Kudyidzana kwemarudzi akasiyana-siyana kusimudzira kunzwisisa kwedu kwe centriole replication
Centriole kudzokorodza inzira yakaoma uye inonakidza inoda kudyidzana kwemarudzi kuti tifambise kunzwisisa kwedu. Maitiro aya akakosha pakuumbwa uye kushanda kwema centrosomes mumasero, ayo anoita basa rakakosha mukukamura maseru uye cytoskeletal organisation. Pazasi pane mamwe ekubatana kwakakosha kwakasimudzira kunzwisisa kwedu kwechiitiko ichi:
1. Cell biology: Cell biology yakapa hwaro hwekunzwisisa chimiro uye basa remacentrioles. Vachishandisa maikorosikopu uye mapuroteni ekunyora mapuroteni, vaongorori vakakwanisa kufungidzira zvikamu zvakasiyana zvemacentrioles panguva yekudzokorora uye kuona maunganiro azvinoita uye kutevedzera. Uyezve, cell biology yakabatsira pakuona mapuroteni akakosha anobatanidzwa mukuita uku uye kunzwisisa kudzora kwavo.
2. Biochemistry: Biochemistry yanga yakakosha pakudzidza kudyidzana pakati pemapuroteni anosanganisirwa mukudzokorodza kwecentriole. Vachishandisa mapuroteni ekuchenesa uye maitiro ekuongorora, biochemists vakakwanisa kuona kushamwaridzana pakati pemapuroteni akasiyana uye kuona kuti basa ravo uye nzvimbo mukati me centrioles zvinodzorwa sei. Izvi zvakatibvumira kuti tinzwisise zviri nani nzira dzema molecular dzinobatanidzwa mukudzokororwa kweiyi organelles.
3. Molecular genetics: Molecular genetics yakapa ruzivo rwakakosha nezvemajini uye nzira dzechiratidzo dzinodzora kudzokorora kwecentriole. Kuburikidza nezvidzidzo mumhando dzemajini senge mbiriso uye zvipenyu zvemhando, ma geneticists akacherechedza majini akakosha anobatanidzwa mukuita uku uye akaburitsa kudyidzana pakati pavo. Uyezve, molecular genetics yakaita kuti zvikwanisike kugadzira zviedzo zvekushandisa kutaura kwemajini aya uye kudzidza maitiro avo pakudzokorora kwecentriole.
13. Muono wakakosha wekuwanikwa kwezvitsva zvekurapa zvakanangana ne centriole replication
Mumakore achangopfuura, kufambira mberi kwakakosha kwakaitwa mukunzwisisa kwedu maitiro ekudzokorora kwe centrioles, zvimiro zvakakosha pakuita kwakakodzera kwesero. Kufambira mberi uku kwakavhura tarisiro nyowani dzekuwanikwa kwekurapa kwakanangana nekugadzirisa centriole replication, nechinangwa chekurapa zvirwere zvine chekuita necentriole dysfunction.
Imwe yetarisiro yakakosha yekuwana marapirwo matsva ndeyekuzivikanwa kwema molecular regulators e centriole replication. Zvinhu zvakasiyana-siyana zvinobatanidzwa mukuita uku zvakaonekwa, kusanganisira mapuroteni chaiwo uye kwete-coding RNA. Kunyatsonzwisisa kwekushanda kweaya maregulator uye kudyidzana kwavo nezvimwe zvikamu zvecentriole zvinogona kubatsira kugadzira nzira dzekurapa dzakanangwa.
Imwe tarisiro inovimbisa ndeyekuvandudzwa kweakananga inhibitors ye centriole replication. Aya inhibitors anogona kuita nekuvhara matanho akasiyana ekudzokorora kana kupindira ne centriole quality control systems. Uyezve, matekinoroji matsva senge gene therapy kana gene expression modulation ari kuongororwa kunyatso kudzora kudzokorora kwecentriole.
14. Mhedziso uye mazano ezvidzidzo zvenguva yemberi pamusoro pekudzokorora kwecentriole
Mukupedzisa, kudzidza kwe centriole kudzokorora kwakapa nzwisiso yakakosha mune iyi yakakosha maitiro mumaseru. Kuburikidza nekutsvagisa kwakasimba uye kuyedza kwakadzama, takakwanisa kuona nzira dzakakosha dzinobatanidzwa mukudzokororwa kwecentriole. Izvi zvakawanikwa zvakabatsira zvakanyanya kuruzivo rwedu rwe cell biology uye zvinogona kuve nezvakakosha pakurapa.
Kubva pane zvakabuda muongororo iyi, kurudziro inogona kuitwa yetsvakiridzo yeramangwana. Aya mazano anosanganisira:
1. Zamisa manzwisisiro edu ezvekudzora zvinhu zve centriole kudzokorora: Kunyangwe zvinhu zvakati wandei zvinosanganisirwa mukudzokororwa kwecentriole zvakaonekwa, zvakawanda zvichiri kuda kuwanikwa. Basa remapuroteni aya uye kudyidzana kwawo nezvimwe zvikamu zvemaserura zvinoda kumwe kuferefetwa kuti uwane mufananidzo uzere wekuti maitiro aya anodzorwa sei.
2. Kuongorora basa re centriole replication muchirwere: Sezvo centrioles achiita basa rinokosha mukuumbwa kwecilia uye kupatsanurwa kwesero, zvakakosha kuongorora kuti kuchinja kwe centriole replication kungave kwakabatana sei nezvirwere zvakadai sekenza uye genetic disorders. Zvidzidzo izvi zvinogona kupa nzira nyowani dzekurapa kugadzirisa aya mamiriro.
3. Shandisa nzira yakasiyana-siyana: Centriole replication inzira yakaoma inosanganisira kupindirana pakati pemamorekuru akasiyana uye cellular organelles. Naizvozvo, maitiro akasiyana-siyana anosanganisira molecular biology, biochemistry, uye advanced microscopy tekinoroji inokurudzirwa kufambisira mberi kunzwisisa kwedu kweiyi yakakosha maitiro musero biology.
Muchidimbu, kudzidza kwe centriole kudzokororwa kwakapa nzwisiso yakakosha mukuita uku kwakakosha mumaseru. Nekudaro, zvakawanda zvichiri kuda kuwanikwa, uye zvidzidzo zvenguva yemberi zvinodikanwa kudzamisa kunzwisisa kwedu kwechiitiko ichi. Nekutevera kurudziro yakapihwa pamusoro uye nekushandisa nzira yemhando dzakasiyana-siyana, tinogona kufambisira mberi manzwisisiro edu ekudzokorodza kwecentriole uye kukosha kwayo. yehutano munhu.
Mibvunzo neMhinduro
Mubvunzo: Chii chinonzi cell cycle?
A: Kutenderera kwesero ndiyo nzira iyo sero rinodzokorora uye kupatsanurwa kuita vanasikana vatsva.
Mubvunzo: Chii chinonzi centriole replication?
A: Centriole replication ndiyo nzira inoshandiswa necentrioles, microscopic cell structures, inodzokorora panguva yesero kutenderera.
Mubvunzo: Ndeipi basa re centrioles?
A: Centrioles ane mabasa akati wandei akakosha muchitokisi, kusanganisira kutora chikamu mukuumbwa kwemitotic spindle panguva yekupatsanurwa kwesero uye kuronga ma microtubules e cytoskeleton.
Q: Mune chii cell cycle phase centriole kudzokororwa kunoitika?
A: Kudzokorora kweCentriole kunoitika panguva yepakati pechikamu chesero kutenderera. Muchikamu ichi, macentrioles anodzokorora sero risati ratanga kupatsanurana.
Mubvunzo: Ndeipi nzira ye centriole replication?
A: Maitiro ekudzokorodza centriole anotanga nekugadzirwa kwecentriole itsva pedyo necentriole iripo. Izvo zvinodikanwa zvinozogadzirwa uye zvinounganidzwa kuti zvigadzire nyowani centriole pair.
Mubvunzo: Ndezvipi zvinhu zvinogadzirisa centriole kudzokorora?
A: Centriole replication inodzorwa nezvinhu zvakati wandei, zvinosanganisira protein kinases uye protein complexes inodzora DNA replication chiitiko.
Mubvunzo: Chii chinoitika kana centriole replication ikasaitika nemazvo?
A: Kana centriole replication ikasaitika nemazvo, shanduko muchimiro checentriole kana nhamba inogona kuitika, inogona kukanganisa cytoskeletal organisation uye cell function.
Mubvunzo: Ndedzipi kufambira mberi kwesainzi kwakaitwa mukudzidza kwe centriole replication?
A: Kuburikidza nemaitiro epamusoro emicroscope uye kugadzirwa kwemajini, takakwanisa kuwana kunzwisisa kwakadzama kwemaitiro emamorekuru anodzora kudzokorora kwe centriole uye kukosha kwavo kukupatsanurwa kwesero.
Muchidimbu
Mukupedzisa, kudzokorodza kwecentriole inzira yakakosha mukutenderera kwesero inova nechokwadi chekugovaniswa kwakaringana kwemakromosome panguva yekukamurwa kwesero. Mumatanho ese ekudzokorora, nhevedzano yezviitiko zvakaoma uye zvakadzorwa zvinoitika izvo zvinovimbisa kuumbwa kwemaviri maviri emacentrioles anoshanda musero remwanasikana wega wega. Kunyange zvazvo kufambira mberi kukuru kwakaitwa mukunzwisisa muitiro uyu, mibvunzo mizhinji yasara. Tsvagiridzo yeramangwana yakanangana nekufumura mamorekuru uye ekudzora nzira dzekudzokorodza kwecentriole ichapa maonero akazara ekutenderera kwesero uye inogona kuve nezvainoreva kumushonga uye gene therapy. Pakupedzisira, kudzidza kwe centriole kudzokororwa kunotitora parwendo runonakidza kusvika pakunzwisisa zvakavanzika zvesero kutenderera uye zvazvinoreva kune cell biology.
Ini ndiri Sebastián Vidal, injiniya wekombuta anofarira nezve tekinoroji uye DIY. Uyezve, ndini musiki we tecnobits.com, kwandinogovera zvidzidzo kuti tekinoroji iwanikwe uye inonzwisisika kumunhu wese.