Lactobacilli Cell Wall

Kugadziridzwa kwekupedzisira: 30/08/2023
Munyori: Sebastian Vidal

Nhanganyaya: Lactobacilli Cell Wall

Lactobacilli ilactic acid mabhakitiriya anoparadzirwa munzvimbo dzakasiyana-siyana, senge gastrointestinal turakiti remhuka nevanhu, zvirimwa, chikafu chakaviriswa uye zvigadzirwa zvemukaka. Aya ma microorganisms ⁢anonyanya kuzivikanwa⁤ nekugona kwavo kugadzira lactic acid ⁣sechigadzirwa chekupedzisira chemetabolism yavo. Pamusoro pehunhu uhu, lactobacilli ine yakasarudzika chimiro chinovasiyanisa kubva kune mamwe mabhakitiriya genera: sero madziro.

The Bacterial cell wall is a rigid outer layer inopa tsigiro nedziviriro kumasero ebhakitiriya. Inoitawo basa rakakosha mukudyidzana kwebhakitiriya nenharaunda yavo uye nemamwe ma microorganisms. Panyaya ye lactobacilli, kuumbwa uye kuumbwa kwemadziro emasero avo kwave kuri nyaya yekudzidza kwemakumi emakore, nekuda kwekukosha kwayo munzvimbo dzakasiyana siyana senge indasitiri yechikafu, hutano, uye biotechnology.

Muchikamu chino, tichanyatsoongorora kuumbwa uye hunhu hwesero madziro e lactobacilli, tichisimbisa maitiro ayo pakushanda uye mashandisirwo eaya ma microorganisms. Pamusoro pezvo, isu tichaongorora matekiniki anoshandiswa pakudzidza kwayo uye zvingangove zvebiotechnological mashandisirwo anobva mukushandiswa kwesero madziro elactobacilli.

Kuburikidza nekuongorora uku, isu tichadzamisa ruzivo rwedu rwe lactobacilli uye sero madziro avo, tichipa tekinoroji uye isina kwayakarerekera maonero pane aya akakosha ma microorganisms. Kunzwisisa chimiro uye mabasa yemadziro sero re lactobacilli richatibvumira kutora mukana wezvavanogona munzvimbo dzakasiyana sekugadzirwa kweprobiotic chikafu, kurapwa kwezvirwere uye genetic engineering.

1.- Nhanganyaya kuLactobacilli Cell Wall: Kukosha uye hunhu hwese

Lactobacilli iboka relactic acid mabhakitiriya anoita basa rakakosha mukuvirisa lactic acid uye kugadzirwa kwechikafu chakaviriswa. Aya mabhakitiriya ane rusvingo rwakasiyana-siyana rwesero, rinonyanya kuumbwa ne peptidoglycan, iyo inovapa kugadzikana uye kurwisana nemamiriro ezvinhu asina kunaka. Kukosha kwelactobacilli kuri mukukwanisa kwavo kugadzira ma enzymes anobatsira kugayiwa uye kutorwa kwezvinovaka muviri, pamwe chete nebasa ravo seprobiotics, ndiko kuti, tupukanana tunobatsira hutano.

Nezve hunhu huzhinji hwelactobacilli, zvakakosha kutaura kuti iwo mabhakitiriya eGram-positive, zvinoreva kuti vanochengeta tsvina yecrystal violet mumadziro emadziro panguva yekuedzwa kweGram stain. Pamusoro pezvo, iwo anodzidzisa anaerobes, ⁢kureva, anogona kukura muhupo uye kusavapo kweokisijeni. Chimwe chimiro chakakosha kugona kwayo kuvirisa zvakasiyana siyana zvesubstrates, ichigadzira lactic acid sechigadzirwa chekupedzisira. Kuvirisa uku kunovapa basa rakakosha mukugadzirwa kwezvekudya zvemukaka zvakaita seyogati nechizi.

Sero madziro e lactobacilli anewo zvimwe zvikamu zvakaita se teichoic acids, lipoteichoic acid uye polysaccharides izvo zvinobatsira mukushanda kwayo uye kugona kudyidzana nenharaunda. Izvi zvikamu, zvakasanganiswa nekuramba kwavo bile acids uye kugona kwavo kukorokoza gastrointestinal turakiti, inoita lactobacilli boka rebhakitiriya rinonyanya kukosha mumunda wemicrobiology uye hutano hwevanhu. Muchidimbu, lactobacilli ma microorganisms ane hunhu hwakasiyana uye hwekukosha kukuru, muindasitiri yezvekudya uye muhutano hwevanhu.

2.- Kuumbwa kwemaitiro emadziro emadziro eLactobacilli uye simba rayo pamabasa ehupenyu

Iro sero madziro eLactobacilli chimiro chakaoma chinoita basa rakakosha mukuita kwavo kwehupenyu. Iyo inonyanya kuumbwa nemapolysaccharides, mapuroteni uye lipids anoumba matatu-dimensional network yakatenderedza sero. Izvi zvikamu zvinopa kupikisa kune sero uye zvinodzivirira kubva kune osmotic lysis, mukuwedzera pakuve nemhosva yechimiro chayo uye kugadzikana kwechimiro.

Pakati pemapolysaccharides aripo mumadziro emadziro eLactobacilli pane peptidoglycan uye pamusoro pepolysaccharides. Peptidoglycan chimiro chakasimba chinoumbwa nekudzokorora zvikamu zveN-acetylglucosamine uye N-acetylmuramic acid, izvo zvakabatanidzwa nemabhiriji epeptide. Ichi chikamu chinopa kuomarara uye kuramba kune cell wall. Kune rimwe divi, mapolysaccharides epamusoro anoshanduka uye anochinja-chinja mamorekuru anowanikwa muchikamu chekunze. yemadziro emadziro, uye kuita basa rakakosha mukudyidzana kweLactobacilli nenzvimbo yavo.

Mapuroteni aripo musero madziro eLactobacilli akasiyana uye anotamba. mabasa akakosha mubasa rehupenyu hwemasero. Aya mapuroteni anogona kubatanidzwa zvakabatana kune peptidoglycan, achigadzira izvo zvinozivikanwa seanchoring mapuroteni kana ma-cross-links. Kune zvakare mapuroteni anosunga anodyidzana zvakananga nezvikamu zvekunze kwenzvimbo, senge shuga mamorekuru kana extracellular matrix mapuroteni. Kudyidzana uku kwakakosha pakunamira kweLactobacilli kumusoro, colonization yematishu uye mhinduro yekudzivirira.

3.- Mabasa akakosha emadziro esero⁢ mu⁤Lactobacilli: kuchengetedzwa, kugadzikana uye ⁢ mutemo

Iwo akakosha mabasa echitokisi madziro muLactobacilli akakosha kwakakosha kuti vararame uye nekushanda kwakanaka. Mupfungwa iyi, mabasa matatu makuru anomira pachena: kudzivirira, kugadzikana uye kudzora.

Dziviriro: Iyo sero madziro eLactobacilli inoshanda sechidziviriro chekudzivirira kubva kune vekunze vamiririri, senge chepfu yebhakitiriya uye zvinhu zvemakemikari zviripo munharaunda. Mukuwedzera, inopa humwe hudziviriro kuburikidza nekuita semutsara wekutanga wekudzivirira kubva pakupinda kwehutachiona, kudzivirira kunamatira kwavo uye colonization pane mucosal nzvimbo dzemuenzi.

Kugadzikana: Rusvingo rwesero runopawo kugadzikana kwe ⁢Lactobacilli.⁣ Nekuda kwehunhu uhu, masero ebhakitiriya anogona kuramba akashata mamiriro ekunze, senge ⁤pH shanduko, tembiricha yepamusoro⁢ uye kusiyana kweosmotic. Saizvozvo, sero madziro inovimbisa kuvimbika kweserura uye inodzivirira bhakitiriya lysis uye apoptosis.

Mutemo: Rusvingo rwesero runoita basa rakakosha mukudzora kwemaitiro emuviri eLactobacilli. Kuburikidza neakasiyana zvikamu zvemadziro, senge polysaccharides uye peptides, adhesion, colonization uye kupindirana nemugamuchiri kunogona kugadziridzwa. Uyezve, kuoma uye kuumbwa kwemadziro kunogona kukanganisa kukwanisa kukonzera mhinduro dzekudzivirira, izvo zvinonyanya kukosha kuhutano hwematumbo uye mhinduro yemunharaunda.

4.- Kudzidza kwekusiyana kwemaitiro uye kuumbwa kwesero rusvingo rweLactobacilli

Lactobacilli⁢ akadzidzwa zvakanyanya ma microorganisms nekuda kwekukosha kwawo munzvimbo dzakasiyana siyana senge indasitiri yechikafu uye hutano hwevanhu. Muchikamu chino, tichagadzirisa chidzidzo chekusiyana kwechimiro uye kuumbwa kwesero madziro eiyi microorganisms.

Iyo sero madziro e lactobacilli chinhu chakakosha chimiro chinopa dziviriro uye kusimba kumaseru. Iyo inonyanya kuumbwa ne peptidoglycan, polymer inoumba matatu-dimensional mesh yakatenderedza sero. Nekudaro, kusiyanisa kukuru mukuumbwa kweiyi peptidoglycan kwakaonekwa pakati pemarudzi akasiyana-siyana uye mhando dzelactobacilli.

Mukuwedzera kune peptidoglycan, sero wall ye lactobacilli inogona kunge iine zvimwe zvikamu zvakadai se teichoic acids, polysaccharides uye mapuroteni. Kuvapo uye kuwanda kwezvikamu izvi zvinogona kusiyanisa zvakanyanya pakati pemhando dzakasiyana dze lactobacilli, iyo inobatsira mukusiyana kwavo maererano ne phenotypic uye maitiro ekushanda. Iyi misiyano muchimiro uye kuumbwa kwesero wall inogona kukanganisa kuramba kune yakaipa mamiriro ezvakatipoteredza, kugona kuomerera kune nzvimbo uye kupindirana. nehurongwa immunological, pakati pemamwe mabasa ehupenyu.

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5.- Kudyidzana kweLactobacilli Cell Wall nenharaunda uye mamwe ma microorganisms

Kudyidzana kwelactobacilli nemhoteredzo uye humwe hutachiona chinhu chakakosha kutariswa mukudzidza kweaya ma microorganisms. Lactobacilli mabhakitiriya anoratidzwa nekugona kwavo kuvirisa shuga nekuashandura kuita lactic acid.

Iyo cell wall ye lactobacilli inoita basa rakakosha mukudyidzana kwavo ne nharaunda uye mamwe ma microorganisms. Ichi chimiro chine mutsara wemaitiro anobvumira kuchengetedza mabhakitiriya kubva mumamiriro ezvinhu asina kunaka uye kuita kuti kusungirirwa kwawo kune nzvimbo. Kumwe kwekudyidzana kunozivikanwa kwe lactobacilli ndeiyi:

  • Makwikwi nemamwe ma microorganisms: Lactobacilli inogona kukwikwidzana nemamwe ma microorganisms kune zvinovaka muviri uye nzvimbo munzvimbo. Kugona kwavo kugadzira lactic acid nezvimwe zvinhu zvinorwisa utachiona zvinovapa mukana wekukwikwidza.
  • Synergies nemamwe ma microorganisms: Mune zvimwe zviitiko, lactobacilli inogona kutanga kuwirirana nemamwe tupukanana, senge mamwe marudzi ebifidobacteria. Kudyidzana uku kunogona kubatsira kune ese mamicroorganisms, sezvo achikwanisa kuzadzana mumabasa avo emetabolic.
  • Kudyidzana neanotambira: Lactobacilli inogona zvakare kudyidzana neanotambira muchiitiko cheprobiotics. Aya ma microorganisms anogona kuzadza dumbu remunhu uye kuita hutano hunobatsira, hwakadai sekuvandudza intestinal kushanda uye kukurudzira immune system.

Mukupedzisa, kudyidzana kwelactobacilli nemhoteredzo uye humwe hutachiona inyaya ine kukosha kukuru mumicrobiology. Aya mabhakitiriya anoshandisa mudhuri wesero uye mamwe mazano kukwikwidza nemamwe utachiona, kutanga kuwirirana uye kubatsira mugamuchiri. Kudzidza kwekudyidzana uku kunogona kubatsira mukuvandudza kweprobiotics uye mamwe maapplication biotechnological.

6.- Zvinogona kubatsira kune hutano hwevanhu hunoenderana nekuvapo kweLactobacilli Cellular Wall

Kuvapo kweLactobacilli Cell Wall mumuviri wemunhu kunopa nhevedzano yeanogona hutano mabhenefiti. Aya mabhenefiti anokonzerwa neakasarudzika zvivakwa zve lactobacilli, izvo zvinogona kubatsira mukuvandudza kugona kwe immune system uye kusimudzira hutano mumatumbo microbiota.

Mamwe emabhenefiti ehutano anoenderana neLactobacilli Cell Wall ndeaya:

  • Kusimbiswa⁤ kwe immune system: Lactobacilli ine simba rekukurudzira kugadzirwa kwemamwe maseru edziviriro, ayo anogona kubatsira kusimbisa maitiro ekudzivirira kwemuviri kune hutachiona uye zvirwere.
  • Kuvandudzwa kwehutano hwematumbo: Lactobacilli inogona kubatsira kuchengetedza hutano mune gut microbiota nekudzivisa kukura kwebhakitiriya inokuvadza. Izvi zvinogona kubatsira kuvandudza kugayiwa, kutorwa kwezvikafu uye kuderedza zviratidzo zvine chekuita nekusagadzikana kwematumbo senge manyoka.
  • Kusimudzirwa kwehutano hwevaginal: Mamwe marudzi e lactobacilli anogona kunge aripo mumukadzi uye anoita basa rakakosha mukudzivirira hutachiona hwemukadzi, senge hunokonzerwa neCandida bacteria.

Aya ⁢angori mamwe ⁢anogona kubatsirikana pahutano akabatana ne⁤Lactobacilli ⁤Cell Wall. Nekudaro, zvakakosha kuti tirambe tichiziva kuti tsvakiridzo mundima iyi ichiri mukuvandudzwa uye zvimwe zvidzidzo zvinodikanwa kusimbisa uye kunyatsonzwisisa mhedzisiro yezvipembenene izvi pamuviri wemunhu.

7.- ⁢Zvinoitika muindasitiri yechikafu neprobiotics: mashandisirwo uye⁤ optimization yesero madziro eLactobacilli.

Tsvagiridzo ⁢Panezvinorehwa muindasitiri yechikafu neprobiotic yakaratidza mashandisirwo akasiyana siyana nemikana yekukwirisa madziro emasero eLactobacilli.⁤ Aya ma microorganisms aripo zvakasikwa Muchikafu chakadai seyoghuti, zvakaratidzwa kuve nemhedzisiro inobatsira pahutano hwevanhu, kuvandudza kugaya uye kusimbisa immune system. ⁤Kuburikidza nekugadziridzwa kwesero madziro, zvinogoneka kukwidziridza zvimiro zvayo zveprobiotic uye kuwedzera kushandiswa kwayo muzvigadzirwa zvekudya⁤ uye zvekudya zvinowedzera.

Imwe ⁤ yeanonyanya kuzivikanwa⁢ mashandisirwo eiyo⁢ optimization yesero madziro eLactobacilli iri mukugadzirwa kwezvikafu zvinoshanda. Zvikafu izvi zvine zvinongedzo zvinopa humwe hutano hwakanaka kupfuura kukosha kwavo kwekudya. Nekuvandudza kugona kweLactobacilli kunamatira kumadziro emukati uye kupona kuburikidza nemudumbu rekudya, chikafu chinoshanda chine huwandu hwepamusoro hweanoshanda probiotics inogona kuwanikwa. Izvi zvinonyanya kukosha kune vanhu vane gastrointestinal kusagadzikana kana vanoda kusimbisa intestinal microbiota.

Imwe munda uko zvinorehwa nekugadzirisa iyo Lactobacilli cell wall iri kuongororwa iri muindasitiri yeprobiotics. Zvidzidzo zvenguva pfupi yapfuura ⁤zvakaratidza kuti kugadziridzwa kwemadziro emasero kunogona kuwedzera ⁢kugadzikana uye kushanda kwe⁤mamicroorganisms aya panguva⁤ kugadzira nekuchengetedza. Mukuwedzera, zvakaonekwa kuti optimization yemadziro emadziro inogona kuvandudza kurwisana kwayo nemamiriro ezvinhu akaipa, akadai semudumbu acidity, iyo inokosha kuti ive nechokwadi chekushanda kweprobiotics. Uku kufambira mberi muLactobacillus tekinoroji kunovhura mikana mitsva mukugadzirwa kwezvigadzirwa zveprobiotic. mhando yepamusoro ⁤uye⁢ kushanda zvakanaka.

8.- Nzira dzekutsvakurudza uye nzira dzekuongorora dzekudzidza kweCell Wall Lactobacilli

Iyo sero madziro eLactobacilli chinhu chakakosha kuti unzwisise chimiro chavo uye basa. Kuongorora uye kuongorora chimiro ichi, nzira dzakasiyana-siyana uye matekiniki anoshandiswa kuwana ruzivo rwakadzama nezve kuumbwa kwayo uye zvimiro. Tevere, isu tinopa dzimwe nzira dzinoshandiswa zvakanyanya mukudzidza kwesero madziro eLactobacilli:

1. Transmission electron microscopy (TEM): Iyi tekinoroji inotibvumira kuwana⁤ yakakwirira resolution mifananidzo yesero madziro eLactobacilli pamwero wemicroscopic. Kuburikidza neTEM, zvikamu zvakasiyana-siyana zvemadziro emadziro zvinogona kuonekwa, zvakadai se teichoic acids, polysaccharides uye mapuroteni Mukuwedzera, iyi nzira inobvumira kuziva kuchinja kwemaitiro emadziro emadziro maererano nemamiriro ezvakatipoteredza kana marapirwo chaiwo.

2. Thin layer chromatography: Thin layer chromatography inzira inoshandiswa kupatsanura uye kuongorora zvikamu zvakasiyana zvesero madziro eLactobacilli. Uchishandisa nzira iyi, zvinokwanisika kuziva lipids, polysaccharides uye mamwe metabolites aripo muchitokisi rusvingo. Uye zvakare, mutete layer chromatography inobvumira kuona kuumbwa kwesero madziro uye kuziva shanduko dzinogoneka dzinogona kuitika mukupindura kwakasiyana tsika mamiriro.

3. Fourier shandura infrared spectroscopy (FTIR): FTIR inzira inotibvumira kuongorora chimiro chemakemikari ezvikamu zviripo musero madziro eLactobacilli. Uchishandisa hunyanzvi uhu, ma spectra anowanikwa anopa ruzivo nezve mapoka anoshanda aripo muzvikamu zvesero madziro, senge peptide bond, carboxyl mapoka uye hydroxyl mapoka. FTIR inzira inobatsira yekuona shanduko mukuumbwa kwemakemikari emadziro esero uye kuenzanisa akasiyana strains eLactobacilli maererano nekuumbwa kwavo.

9.- Matambudziko uye maonero emangwana mukutsvaga kweLactobacilli Cell Wall

Matambudziko uye maonero emangwana mukutsvaga paLactobacilli Cell Wall

Tsvagiridzo pa⁤Lactobacilli‍ Cell Wall inosangana nematambudziko akasiyana uye inopa maonero anonakidza ⁢emangwana. Pazasi pane mamwe ematambudziko makuru ekukurirwa uye nemikana iri pamberi:

Matambudziko:

  • Ziva uye unzwisise zvirinani kuumbwa uye chimiro chesero madziro eLactobacilli, sezvo mavakirwo ayo akakosha pakuita kwayo biological basa uye maindasitiri ekushandisa.
  • Gadzirisa kushayikwa kwenzira dzinoshanda dzekuratidzira uye kuenzanisa zvikamu zvakasiyana zvemadziro emadziro nekukurumidza uye nemazvo.
  • Kunda zvipimo zvetekinoroji uye zvemari kutsvagisa nekugadzira mitsva yeLactobacilli ine zvinobatsira zvivakwa zvehutano uye mashandisiro muchikafu nezvinwiwa.
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Tarisiro yeramangwana:

  • Shandisa genetic engineering maitiro ekugadzirisa kuumbwa kwesero madziro eLactobacilli uye kuvandudza maitiro avo maererano nekupokana nemamiriro akanyanya, kugadzirwa kwematabolites, kudyidzana neanotambira, pakati pezvimwe.
  • Ongorora kugona kweLactobacilli mumushonga wemunhu, seanorapa ekurapa zvirwere zvegastrointestinal, immunomodulation uye kudzivirira kwezvirwere zvisingaperi.
  • Gadzira ⁤mitsva yekuvirisa modhi uye bioproducts kubva kuLactobacilli ine chaiyo inoshanda zvivakwa, ⁤kugadziridza zvinodikanwa uye zvinodiwa⁤ muindasitiri yechikafu neinovaka muviri.

Mukupedzisa, kunyangwe paine matambudziko aripo, tsvakiridzo muCell Wall Lactobacilli inopa inovimbisa ndima yekufambira mberi kwesainzi uye tekinoroji. Kunzwisisa kuri nani kwechimiro uye kushanda kwesero madziro eaya ma microorganisms kwakakosha kutora mukana wakazara wezvaanogona mundima dzakasiyana dzekushandisa.

10.- Kurudziro yekushandiswa kwakanaka kweLactobacilli ⁤Cellular ⁤Wall muindasitiri

Kurudziro yekushandiswa kwakanaka kweLactobacilli Cell Wall muindasitiri iyi

Kushandiswa kweLactobacilli ⁣Cell Wall muindasitiri yechikafu yave kuramba ichizivikanwa nekuda kwezvakanaka izvo ⁤microorganisms ⁤zvinopa maererano nehutano uye mhando yechigadzirwa. Nekudaro, kuti uve nechokwadi chekushandisa kwakanaka uye kuwedzera mhedzisiro yayo, zvinodikanwa kutevedzera mamwe mazano:

1. Kusarudzwa kwakakodzera kweLactobacilli Cell Wall: Izvo zvakakosha kuti usarudze chaiwo strains eCell Wall Lactobacilli inoenderana nezvigadzirwa uye maitiro eiyo indasitiri iri mubvunzo. Imwe neimwe dhizaini ine humwe hunhu uye mabhenefiti, saka, zvakakosha kutsvaga zano uye kusarudza iro rinonyatsoenderana nezvinodiwa chaizvo nekambani.

2. Kudzora kwakakwana kwemamiriro ekuvirisa: Kuti uve nechokwadi chekushanda kweLactobacilli Cellular Wall, zvakakosha kuchengetedza kwakasimba kutonga kwemamiriro ekuvirisa. Izvi zvinosanganisira kugara uchitarisisa tembiricha, pH, kusungirirwa kwezvikafu, uye nguva yekuvirisa Nzvimbo yakakodzera yakakosha kusimudzira uye kuwanda kweLactobacilli Cell Wall, pamwe nekuita kwavo kwakanyanya.

3. Kutarisisa uye ongororo⁢ yezvabuda: ⁤Zvinokurudzirwa kuramba uchiongorora uye kuongorora zvawanikwa mushure mekushandiswa kweLactobacilli⁤ Cell Wall. Izvi zvinosanganisira kuongorora kuvandudzwa kwemhando yechigadzirwa, kuongorora maitiro ayo pasherufu uye kuchengetedzwa kwechikafu, pamwe nekupa mhinduro kune vatengi kuti vaongorore kugamuchirwa. Iyo data yakaunganidzwa⁤ inobvumira kugadziridza uye kukwenenzvera mashandisirwo⁤ eaya ⁢microorganisms. zvinobudirira uye inoshanda mune ramangwana.

11.- Ongororo yekukanganisa kweLactobacillus cell wall pane hutano hwemhuka uye inogona kushandiswa mukurapa kwezvipfuyo.

Rusvingo rwesero reLactobacilli, rudzi rwebhakitiriya runobatsira, rwakamutsa kufarira kukuru munharaunda yesainzi nekuda kwekugona kuita hutano hwemhuka. Zvidzidzo zvakawanda zvakaitwa kuongorora mhedzisiro yeiyi sero madziro mumhando dzakasiyana dzemhuka, senge mombe, nguruve uye huku. Mhedzisiro kusvika parizvino inoratidza kuti manejimendi eLactobacilli uye sero madziro avo anogona kusimudzira nhevedzano yehutano hwehutano hwemhuka, pamwe nekupa mikana yekushandisa kwavo mukurapa wemhuka.

Zvimwe zvezvinonyanya kuzivikanwa zvakawanikwa kubva mukuongororwa uku zvinosanganisira:

  • Kuvandudzwa ⁤Kushanda kwemudumbu: Sero madziro eLactobacilli akaratidzwa kuva ane prebiotic properties uye anogona kukurudzira kukura kwebhakitiriya rinobatsira mudumbu remhuka. kusimbisa barrier function of the intestine.
  • Kukurudzira immune system: Zvakaonekwa kuti kutonga kweLactobacilli uye madziro emasero ayo anogona kuwedzera immune system mumhuka, nekudaro kusimbisa hurongwa hwavo hwekudzivirira kurwisa zvirwere zvakasiyana uye hutachiona.
  • Kuderedza kushushikana uye kuzvimba: Zvakataurwa kuti sero madziro eLactobacilli anogona kuve nemhedzisiro yekudzikisa kushushikana uye kuzvimba mumhuka nekugadzirisa mhinduro. yetsinga uye chiyero cheproinflammatory cytokines.

Iyi mhedzisiro inovimbisa inovhura maonero matsva mumunda wezvechiremba, uko kuiswa kweLactobacilli nesero madziro echikafu kana sezve zvinovaka muviri zvinogona kuve nzira dzinoshanda dzekuvandudza hutano nekugara zvakanaka kwemhuka. Zvakadaro,⁢ zvakakosha kuratidza kuti kumwe kutsvagisa kuchiri kudikanwa kuti unzwisise zvizere maitirwo ⁢chiito uye⁢ kuona⁢ madosi emhando yemhuka yega yega.

12.- Nzira dzinogona kuitika dzekugadzirisa sero rusvingo rweLactobacilli kuti vavandudze kushanda kwavo

Imwe yedzakanyanya kuvimbisa nzira dzekuvandudza mashandiro eLactobacilli ndiko kugadziridzwa kwesero madziro avo. Nekuita izvi, tinotsvaka kuwedzera kukwanisa kwayo kuomerera kune epithelial masero emudumbu, kuvandudza kugadzikana kwayo panguva yekudya uye kuwedzera kukwanisa kwayo kusunungura bioactive compounds inobatsira kune hutano.

Kune nzira dzakasiyana dzekuzadzisa izvi zvigadziriso, pakati pezvinotevera zvinobuda pachena:

  • Kugadziridza Inosanganisira kushandura chikamu chezvikamu zviripo mumadziro emadziro eLactobacilli, somuenzaniso, unogona kuwedzera huwandu hwe teichoic acids uye exopolysaccharides, iyo mamorekuru anozivikanwa kukurudzira kunamatira kumasero emudumbu.
  • Kubatanidzwa kwebioactive molecules: Zvinosanganisira kuunza bioactive zvinhu musero madziro eLactobacilli kuti iwedzere kushanda kwavo zvivakwa. izvi Zvinogona kuwanikwa kuburikidza nemajini einjiniya matekiniki, sekuunzwa kwemajini ayo kodhi yekugadzirwa kwemakemikari anobatsira kune hutano, senge pfupi chain fatty acids.
  • Cell wall lining: Iyo inosanganisira kuvhara sero madziro eLactobacilli nezvinhu zvinodzivirira kana kuaputira mumapolymeric matrices. ⁢Izvi zvinobatsira kuvandudza⁤ kupikisa kwayo kudumbu acids uye digestive enzymes, uye inofambisa kuburitswa kwayo kunodzora muura.

Aya marongero ekugadzirisa sero madziro eLactobacilli anomiririra nzvimbo inovimbisa yetsvagiridzo mumunda wechikafu biotechnology uye yakashandiswa microbiology. Kushandiswa kwayo kunogona kubvumira dhizaini yemhando yeLactobacilli ine yakagadziridzwa zvivakwa, iyo inogona kushandiswa seyakanyanya kushanda probiotics kukurudzira hutano hwematumbo uye kudzivirira zvirwere.

13.- Kuenzanisa zvidzidzo zve⁢sero madziro ⁢eLactobacilli ⁣ mumhando dzakasiyana uye madhiri.

Rusvingo rwesero reLactobacilli, genus ye gram-positive bacteria, yave iri nyaya yekuenzanisa zvidzidzo kuti tinzwisise maumbirwo ayo uye maumbirwo emhando dzakasiyana-siyana nemhando dzakasiyana-siyana. pamwe chete nezvazvinoreva uye zvingangoitwa muindasitiri yezvekudya nehutano.

Mukuenzanisa zvidzidzo, zvakasiyana-siyana zvakakosha zvikamu zvesero madziro eLactobacilli zvakaonekwa, senge:

  • Peptidoglycan: polymer inoumbwa nemaketani eglucosamine uye muramic acid, iyo inopa mechanical kuramba kumadziro emadziro.
  • Teichoic acids: Anionic mapolymers anokanganisa kukanganisa kwakashata kwesero madziro uye anogona kuita basa mukunamatira kune pamusoro.
  • Peptidoglycan inosunga mapuroteni: ita basa rakakosha mukuita enzymatic ine chekuita neiyo synthesis uye kugadzirisa kwesero madziro.
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Pamusoro pekuongorora zvikamu zvemadziro emadziro, zvidzidzo zvekuenzanisa zvakaongororawo kusiyana kwesangano uye chimiro cheLactobacilli. Izvi zvakawanikwa zvakaratidza kuti mamwe marudzi uye madhirigi anogona kunge aine gobvu sero madziro kana chikamu chepamusoro che teichoic acids. Iyi misiyano inogona kuve yakabatana nekusiyana kwekupokana nehostimmunity kana kune antimicrobial zvinhu, izvo zvinopa maonero akazara emhando dzakasiyana dzeLactobacilli uye kugona kwavo kushandiswa mune ⁤different application.

14.- Mhedziso uye maonero ekupedzisira paLactobacilli Cellular Wall: nzira inoenda kune ruzivo rwakakura uye mashandisirwo.

Mukupedzisa, kudzidza kwelactobacilli masero madziro kwakaratidza ruzivo rwakakosha rwekunzwisisa zviri nani biology yavo uye mashandisiro angangoita. Tichishandisa genomic sequencing matekiniki, zvave zvichigoneka kuona majini matsva anobatanidzwa mukuumbwa kwesero wall yeaya ma microorganisms, ayo anotiswededza pedyo nekuona kwakazara kwechimiro chavo uye basa. Uyezve, zvakaratidzwa kuti cell wall lactobacilli ine immunomodulatory properties uye kukwanisa kupindirana nemukati mucosa, iyo inogona kuva nemigumisiro mukudzivirira uye kurapwa kwezvirwere zvematumbo.

Mukuona, ramangwana rekutsvaga mu lactobacilli cell madziro rinotaridzika kuvimbisa. Zvinotarisirwa kuti kufambira mberi kwetekinoroji kuchatibvumira kudzidza pamwero mukuru kudyidzana pakati pezvipembenene izvi nenharaunda yazvo, pamwe nekuona matsva ebioactive komisheni uye nzira dzekuita. Izvi zvakawanikwa hazvigone kungowedzera ruzivo rwedu nezve lactobacilli cell madziro, asi zvakare zvinopa nzira nyowani dzekurapa dzekurapa zvirwere zvakasiyana siyana zvine chekuita negastrointestinal system uye immune system.

Muchidimbu, kudzidza kwesero madziro lactobacilli kwatitungamira kuti tiwane zvinonakidza zve biology yavo uye zvingangoita mashandisiro. Nekufambira mberi kwega kwega mukunzwisisa kwedu hutachiona uhu, mikana mitsva inovhurika yekushandisa kwavo mumaindasitiri ezvekudya, emishonga uye ehutano. Sezvo isu tichienderera mberi nekuongorora nyika yavo ine microscopic, isu tine chokwadi chekuwana zvakatowanda mabhenefiti uye mashandisiro e lactobacilli cell madziro, zvichiita kuti iyi nharaunda yetsvagiridzo ive nzira yeruzivo rwakakura nemikana.

Mibvunzo neMhinduro

Mubvunzo: Chii chinonzi Lactobacilli ⁢Cell Wall?
A: Cell Wall Lactobacilli mabhakitiriya ane lactic acid anoonekwa nekuva nesero membrane yakapfuma mupolysaccharides, inovapa kupikisa kukuru uye kugona kurarama mudumbu remudumbu.

Mubvunzo: Chii chakakosha cheLactobacilli Cell Wall?
A: Cell Wall Lactobacilli ine akawanda mabhenefiti ehutano, sezvo inosimbisa immune system, inovandudza kugaya, inodzora maruva emudumbu uye kudzivirira zvirwere zvemudumbu. Yakave yakaratidzawo kuti vanogona kuva nemigumisiro yakanaka mukuderedza cholesterol uye kudzivirira mamwe marudzi ekenza.

Mubvunzo: Lactobacilli Cell Wall ⁢inoita sei mumuviri?
A: Sero Wall Lactobacilli kuita kunyanya mudumbu turakiti, apo vanoomerera kuti intestinal mucosa uye kukwikwidzana pathogenic microorganisms, kudzivirira kuwanda kwavo uye kunamatira masero intestinal. Mukuwedzera, vanokurudzira kugadzirwa kwelactic acid nezvimwe zvinhu zvinorwisa utachiona zvinodzivisa kukura kwebhakitiriya inokuvadza uye fungi.

Q: Ndeapi masosi eLactobacilli Cell Wall?
A: Cell Wall Lactobacilli inowanikwa muzvokudya zvakaviriswa zvakadai seyoghurt, cheese, sauerkraut uye miso. Ivo vanogona zvakare kuwanikwa kuburikidza nekudya zvinowedzera uye chaiwo probiotic zvigadzirwa.

Q: Pane contraindications kana divi migumisiro chokuita kudyiwa Cell Wall Lactobacilli?
A: Kazhinji, Cell Wall Lactobacilli yakachengeteka uye inoshivirirwa zvakanaka. Zvisinei, muzviitiko zvisingawanzoitiki, vamwe vanhu vanogona kuona zviratidzo zvishoma zvemudumbu zvakadai se flatulence, kuputika, kana manyoka. Kuchenjerera kunokurudzirwawo muvanhu vane immune system isina simba kana muvarwere vari muchipatara, sezvo panogona kuve nengozi shoma yekutapukirwa.

Mubvunzo: Ndeipi dhigirii yakakurudzirwa yeLactobacilli Cell Wall?
A: Nhamba yakakurudzirwa yeLactobacilli Cell Wall inogona kusiyana zvichienderana nechigadzirwa uye mamiriro emunhu mumwe nomumwe Zvinokurudzirwa kutevera mirairo yemugadziri kana kubvunza chiremba wehutano kuti aone chiyero chakakodzera mune imwe neimwe nyaya.

Mubvunzo: Zvinotora nguva yakareba sei kuti uone mabhenefiti eLactobacilli Cell Wall?
A: Zvakanakira Lactobacilli Cell Wall zvinogona kusiyana. yemunhu kune mumwe uye zvinotsamira pane ⁢zvinhu zvakati wandei, senge dosage, kugara uchinwiwa uye hutano hwese hwemunhu wega wega. mavhiki mashoma, nepo zvimwe zvikomborero zvingada kushandiswa kwenguva refu kuti zvionekwe.

Mubvunzo: Zvakachengeteka here kushandisa Lactobacilli Pared ⁣Serura panguva yekuzvitakura kana kuyamwisa?
A: Kazhinji, Lactobacilli⁤ Cell Wall inoonekwa seyakachengeteka panguva⁢ yepamuviri nekuyamwisa. Zvisinei, zvinokurudzirwa kubvunzurudza chiremba usati watanga kushandiswa kwayo, kunyanya mumamiriro ezvinhu ekudzivirira kwepamuviri kana pamberi pehutano hwakasiyana.

Mubvunzo: Ko Lactobacilli Cellular Wall inogona kusanganiswa nemimwe mishonga here?
A: Kazhinji, Lactobacilli Cell Wall inogona kusanganiswa pasina matambudziko nemimwe mishonga. Zvisinei, zvakakosha kuonana nachiremba kana wemishonga kuti uone kuti hapana kushamwaridzana kusina kunaka nemishonga chaiyo. Zvakakoshawo kutevera mazano emugadziri maererano nenguva yekudya uye kuparadzaniswa kubva pakutora mamwe mishonga.

Q: Ndeapi makuru emhando dzeCell Wall Lactobacilli inoshandiswa mukuwedzera uye zvigadzirwa zveprobiotic?
A: Mamwe emhando dzinowanzo shandiswa dzeCell Wall Lactobacilli iLactobacillus ⁢rhamnosus, Lactobacillus ‍plantarum, Lactobacillus acidophilus uye Lactobacillus casei. Aya madhiri akaratidzwa kuva ane hutano hunobatsira uye akadzidzwa zvakanyanya mukutsvaga kwakasiyana kwesainzi.

Mhedziso

Mukupedzisa, Cell Wall Lactobacilli itsika dzeprobiotic dzinomira pachena pakugona kwavo kusimbisa immune system uye kugadzirisa hutano hwematumbo. Kuumbwa kwavo kwakasiyana-siyana kwemadziro emadziro kunovapa maitiro anokosha, akadai sekukwanisa kunamatira kune intestinal mucosa uye kuramba mamiriro asina kunaka emudumbu.

Aya ma microorganism anobatsira anga ari nyaya yezvidzidzo zvesainzi zvakawanda, izvo zvinotsigira kushanda kwavo mukudzivirira uye kurapwa kwezvirwere zvakasiyana-siyana zvegastrointestinal, pamwe nekutonga kwehutachiona uye kusimbisa immune system.

Tsvagiridzo paCell Wall Lactobacilli inoenderera mberi, nechinangwa chekunzwisisa zvirinani kuchinjika kwavo immune system uye kusangana kwavo nemamwe ma microorganisms aripo muura. Pamusoro pezvo, matekinoroji matsva ari kuongororwa kuti avandudze kugadzirwa uye kudzikamiswa kweaya maprobiotics, nekudaro achivimbisa kugona kwavo uye kugona kwekurapa.

Muchidimbu, Lactobacilli Cell Wall inomiririra chishandiso chine simba mumunda wemicrobiota uye hutano hwematumbo. Basa ravo mukusimudzira optimal microbial chiyero mudumbu uye kugona kwavo kuenzanisa immune system inovaita sarudzo inovimbisa yekudzivirira uye kurapwa kweakasiyana mamiriro.