Bioactive nanoparticles inodzoreredza iyo BBB inononoka chirwere cheAlzheimer mumakonzo

Un timu yenyika, nehutungamiriri kubva kuInstitute of Bioengineering yeCatalonia (IBEC) uye West China Hospital yeSichuan University, yakapa zano renanotechnology iro inodzosera kumashure zviratidzo zveAlzheimer's mumakonzo nekugadzirisa ropa-brain barrier (BBB). Kutaura zvazviri, ndezve shandisa nanoparticles anoshanda semishonga ega kuti kudzorera cerebral vascular function.

Kuchinja kwekutarisa uku kune musoro kana tikarangarira izvozvo uropi hunodya pamusoro 20% yesimba muvakuru zvichikwira 60% muvana, inotsigirwa nedense network ye capillaries apo neuron imwe neimwe inowana rubatsiro. Kana BBB ichishandurwa, hurongwa hwekurasa marara hunotambura uye hunofarira kuunganidzwa kwe beta amyloid (Aβ), chiratidzo chechirwere.Inofungidzirwa kuti uropi hwemunhu hune bhiriyoni imwe chete capillaries, saka kukosha kwehutano hwevascular.

Iri zano renanotechnology rinoratidzei?

Kusiyana neyekare nanomedicine, iyo inoshandisa nanoparticles semotokari chete, nzira iyi inoshandisa supramolecular mishonga izvo zviri bioactive uye hazvidi kutakura imwe musimboti. Chinangwa hachisi neuron, asi iyo BBB sechinangwa chekurapa.

Pasi pemamiriro ezvinhu, Iyo LRP1 receptor inoziva Aβ uye inoifambisa ichiyambuka chipingamupinyi ichipinda muropaIyo system, zvisinei, yakaoma: Kana kusunga kwakanyanyisa kana kusakwana, zvekufambisa hazvina kuenzana uye Aβ inoungana. Iyo yakagadzirwa nanoparticles tevedzera LRP1 ligands kuti uwanezve chiyero ichocho.

Nekupindira uku, nzira yekubuda yemapuroteni ane dambudziko kubva ku parenchyma muropa, inosimudzira Aβ clearance uye normalizing chipingamupinyi basa. Muchidimbu, inogadzirisa zvakare nzira yekuchenesa nzira yehuropi.

Mhuka muenzaniso bvunzo uye zvabuda

Ongororo yakaitwa pamakonzo akagadziridzwa genetically kuti abudise yakakura yeAβ uye kukudziridza kutadza kuziva. Majekiseni matatu ezvimedu izvi aive akakwana kuona shanduko dzinoyerwa mumabhayomarker uye maitiro..

Maererano nevanyori, awa imwe chete mushure mekutonga A 50-60% inoderera muAβ muuropi yakatove yakanyorwaKukurumidza kwekuita kunoratidza kukurumidza kugadziriswa kwechigadziro chekutakura kune chipingamupinyi.

Kupfuura mhedzisiro yekukurumidza, mhedzisiro inogara inotsanangurwa. Mune kumwe kuedza, mbeva yemwedzi gumi nemiviri yakaongororwazve pamwedzi gumi nemisere uye yakaratidza. kuita kwakafanana nekwemhuka ine hutano, zvichiratidza kuenderera mberi kwekushanda kupora mushure mekurapa.

Chikwata chinoturikira kuti pane a chain effect: nekudzorera basa revascular, Kucheneswa kweAβ nemamwe mamorekuru anokuvadza kunotangazve, uye sisitimu inowanazve chiyero.. Mumashoko ehutungamiri hwesainzi, zvimedu zvinoita semushonga uyo inovandudza nzira yekubvisa kusvika kune zvakajairika.

Nyanzvi dzekunze dzinotsanangura kuwanikwa sekuvimbisa, kunyangwe dzichiratidza kuti mhedzisiro yakawanikwa mumurine models uye iyo shanduro kuvarwere inoda kungwarira. Nharaunda inosimbisa kukosha kwekuona kuchengeteka uye kushanda muvanhu vane zvidzidzo zvakasimba.

Molecular engineering kuseri kwenanoparticles

Aya nanoparticles anoumbwa nenzira ye pasi-kumusoro molecular engineering, kubatanidza saizi inodzorwa ne inotsanangurwa nhamba ye ligands pamusoro payo kuti iwirirane nemareceptor neimwe nzira.

Ne modulating the receptor traffic mu membrane, Zvimedu zvinonyatso gadzirisa maitiro ekufambisa kweAβ mhiri kweBBBIyi dhigirii yekurongeka inovhura nzira dze gadzirisa mabasa ekugamuchira izvo kusvika zvino zvaive zvakaoma kushandura nenzira yekurapa.

Saka, kwete chete kubviswa kunobudirira kweAβ kunosimudzirwa, asi Inobatsira rebalance vascular dynamics inotsigira hutano hunoita basa rehuropi.. Uyu ndiwo mutsauko wakakosha kubva kune nzira dzinogumira kune endesa mishonga.

Ndiani ari kutora chikamu uye chii chinotevera?

Iyo Consortium inounza pamwe chete IBEC, West China Hospital uye Xiamen West China Hospital yeSichuan University, iyo University College Londonla Universidad de Barcelona, ICREA, uye Chinese Academy of Medical Sayenzi, pakati pevamwe. Zvakawanikwa zvakaburitswa mujenari Signal Transduction uye Targeted Therapy.

Tichifunga nezveshanduro yacho, rwendo rwacho rwune musoro rwunopfuura kuzvimiririra kusimbiswa, Zvidzidzo zveToxicological, kuongororwa kwedosi uye, kana zvakakodzera, chikamu I / II miedzo yevanhuKuchengeteka uye kuberekana kuchave kiyi yekufambira mberi.

Kunze kweAlzheimer's, basa iri rinotarisa pane hutano hwecerebrovascular sechinhu chakakosha chedementia, kuvhura nzvimbo yekurapa inozadzisa classical neuron-centered approaches.

Iyo data set inoratidza kuti kupindira paropa-brain barriers ne bioactive nanoparticles inogona kukurumidza kuderedza amyloid mutoro, kudzorera vascular basa, uye kuvandudza migumisiro yekuziva mumakonzo; nzira inovimbisa iyo, nekuchenjerera, inofanira kusimbiswa mairi zvidzidzo zvekiriniki yakagadzirwa zvakanaka.