Lisele tsa Fepa Pinocytosis

pinocytosis Ke ts'ebetso ea bohlokoa phepong ea cellular, eo ka eona lisele li kenyang maro le likaroloana tse qhibilihang tse teng tikolohong ea tsona. Ketsahalo ena, e tsejoang hape e le endocytosis ea mokelikeli, e khetholloa e le mokhoa o laoloang haholo o lumellang lisele ho fumana limatlafatsi le ho etsa mesebetsi ea bohlokoa bakeng sa ho phela ha tsona. Sehloohong sena, re tla hlahloba ka ho qaqileng mokhoa oa ho fepa lisele ka pinocytosis, ho hlahloba litšobotsi tsa eona tse ka sehloohong le mekhoa ea ho laola.

Kenyelletso ea pinocytosis ea ho fepa lisele

Pinocytosis ke ts'ebetso ea bohlokoa phepong ea lisele, e lumellang lisele ho fumana limatlafatsi le lintho tse hlokahalang bakeng sa ts'ebetso ea tsona. Mofuta ona oa endocytosis o na le tlhaselo ea lera la sele ho etsa li-vesicles tse nkang maro le likaroloana tse qhibilihisitsoeng tse teng ka har'a extracellular medium.

Nakong ea pinocytosis, lera la plasma le phutha ka har'a sele, le etsa mokotla o monyenyane kapa vesicle e bitsoang endosome. Endosome ena e tsamaea ka har'a cytoplasm mme e kopanya le li-lysosomes, e leng li-organelles tse nang le li-enzyme tsa ho sila lijo. Li-enzyme tsena tse lokollotsoeng ka har'a endosome li tla silafatsa likaroloana tse hapuoeng, li lokolle limatlafatsi tse hlokahalang bakeng sa lijo. metabolism ea sele.

Pinocytosis ke mokhoa o feto-fetohang oa phepelo ea lisele mme o sebelisoa maemong a fapaneng a tlhaho. Ka mohlala, lisele tsa tsamaiso ea 'mele ea ho itšireletsa mafung li sebelisa pinocytosis ho tšoara le ho senya libaktheria le likaroloana tse tsoang linaheng tse ling, ho thusa ho boloka bophelo bo botle ba' mele. Ho phaella moo, lisele tse ling tse khethehileng, tse kang tse fumanoang epithelia e tsamaisang mala, li sebelisa mokhoa ona ho monya limatlafatsi, tse kang tsoekere, amino acid le lipids, tse teng ka har'a mala.

Tlhaloso le ts'ebetso ea pinocytosis ho fepa ka cellular

Pinocytosis ke ts'ebetso ea mantlha ea phepelo ea cellular e lumellang ho ts'oaroa ha likaroloana tsa metsi kapa limolek'hule tse nyane tse qhibilihisitsoeng ho tsoa tikolohong ea kantle ho sele. Ke mokhoa oa bohlokoa bakeng sa lisele, kaha o li fa limatlafatsi tse hlokahalang ho li phetha mesebetsi ea eona metabolism. Ka pinocytosis, lisele li ka monya lintho tse kang amino acid, tsoekere, livithamine le liminerale tsa bohlokoa.

Ts'ebetso ena ea lisele e etsoa ka ho theha li-vesicles tse bitsoang endosomes kapa pinocytic vacuoles. Li-vesicles tsena, tse nang le lera le entsoeng ka phospholipids, li hlaha ho tloha ho hlasela lera la plasma. Hang ha li-vesicle li thehoa, li kena ka seleng, ebe li kopana le li-lysosomes, organelles tse nang le li-enzyme tse senyang lijo. Ho kopanya pakeng tsa li-pinocytic vesicles le lysosomes ho lumella ho senyeha le tšebeliso e latelang ea metsoako e hapuoeng.

Ka bokhutšoanyane, pinocytosis ke mokhoa oa ho fepa ka cellular o bapalang karolo ea bohlokoa ho monyeng ha limatlafatsi. Ka lebaka la ho thehoa ha li-pinocytic vesicles, lisele li khona ho nka lintho tse metsi le limolek'hule tse nyenyane tse qhibilihisitsoeng ho tsoa ho extracellular medium. Ka ho kopanya le li-lysosomes, ho senyeha le ho sebelisoa ha limatlafatsi tse nkiloeng ho etsahala, kahoo ho netefatsa ts'ebetso e nepahetseng le tlhokomelo ea sele.

Mekhoa le mekhahlelo ea pinocytosis maemong a ho fepa ka cellular

Pinocytosis ke mochine oa endocytosis o lumellang ho kenngoa ha metsi le limolek'hule tse nyenyane tse qhibilihang ke sele. Ts'ebetso ena e bohlokoa phepong ea lisele, kaha lisele tsa pinocytosis li ka fumana limatlafatsi le lintho tse hlokahalang bakeng sa ts'ebetso ea tsona e nepahetseng.

Pinocytosis e etsahala ka mekhahlelo e mengata, e leng:

• Sebopeho sa pinocytosis vesicle: Mothating ona, lera la plasma la sele lea kenella ho etsa li-vesicles tse nkang mokelikeli o kantle ho sele.
• Ho kopanya li-vesicles le li-endosome tsa pele: Li-pinocytosis vesicles li kopana le li-endosome tsa pele, tse nang le li-enzyme le liprotheine tse hlokahalang bakeng sa ho lokisa lintho tse nkiloeng.
• Ho kopanngoa ha li-endosome tsa pele le li-endosome tsa morao: Li-endosome tsa pele li kopana le li-endosome tsa morao-rao, moo tšilo e tsoelang pele ea limolek'hule tse nkiloeng li hlahang 'me lisebelisoa tse senyehang li arohanngoa le lisebelisoa tse sa tsitsang.

Ka kakaretso, pinocytosis ke ts'ebetso ea mantlha ea phepo ea cellular, kaha e lumella ho monya limatlafatsi le lintho tse ling tse hlokahalang bakeng sa ts'ebetso e nepahetseng ea lisele. Ka methati e fapaneng, lisele li ka nka maro le limolek'hule tse qhibilihang, li li sebetsa, 'me li li sebelisetsa matla le merero e meng ea metabolism.

Mefuta ea limolek'hule le likaroloana tse amoheloang ke pinocytosis

Pinocytosis ke ts'ebetso ea endocytosis moo sele e monyang limolek'hule le likaroloana tse qhibilihisitsoeng tikolohong ea eona e kantle ho sele. Ka mokhoa ona oa ho monya, sele e ka fumana limatlafatsi le ho laola tikoloho ea eona e ka hare. Ho na le mefuta e fapaneng ea limolek'hule le likaroloana tse kenngoang ka pinocytosis, tse ling tsa tsona li kenyelletsa:

• Liprotheine le li-amino acid: Lisele li ka nka mefuta e fapaneng ea liprotheine ka pinocytosis. Tsena e ka ba liprotheine tse qhibilihang ka metsing kapa liprotheine tse tlamahaneng le limolek'hule tse ling.
• Lipidi: Lipids, joalo ka mafura acid le lihormone tsa steroid, le tsona li ka nkuoa ke sele ka pinocytosis. Li-lipids tsena li etsa mesebetsi e fapaneng 'meleng' me lia hlokahala ho boloka botšepehi ba lisele tsa lisele.
• Matsoai a diminerale: Matsoai a liminerale, joalo ka calcium, sodium le potasiamo, a bohlokoa bakeng sa ts'ebetso e nepahetseng ea lisele. Pinocytosis e ka sebelisoa ho monya matsoai ana a liminerale ho tsoa tikolohong ea kantle ho sele.

Ntle le limolek'hule tsena, pinocytosis e ka boela ea lumella ho monya ha likaroloana tse kang li-extracellular vesicles, libaktheria, livaerase le chefo. Likaroloana tsena li tsejoa 'me li pota-potiloe ke lera la sele, ho etsa li-vesicles tse bitsoang li-pinosomes tseo ka mor'a moo li fetisetsoang ka seleng bakeng sa ho sebetsa.

Ka kakaretso, pinocytosis ke mokhoa oa bohlokoa oa ho fumana limatlafatsi le taolo ea tikoloho ea ka hare ea lisele. Ka mokhoa ona oa ho monya, lisele li ka nka mefuta e mengata ea limolek'hule le likaroloana, ho kenyeletsoa liprotheine, lipids, letsoai la diminerale, li-extracellular vesicles, libaktheria, livaerase le chefo.

Bohlokoa ba pinocytosis ho fumana limatlafatsi ka lisele

Pinocytosis ke ts'ebetso ea bohlokoa bakeng sa lisele ho fumana limatlafatsi tsa bohlokoa bakeng sa ts'ebetso ea tsona e nepahetseng. Mofuta ona oa endocytosis o lumella lisele ho nka limolek'hule tse nyane tse qhibilihisitsoeng sebakeng sa extracellular, joalo ka li-ion, li-amino acid le tsoekere, ka ho theha li-vesicles tse bitsoang pinosomes. Leha palo ea limatlafatsi tse fumanoang ka pinocytosis e le tlase ha e bapisoa le mekhoa e meng ea lipalangoang, bohlokoa ba eona bo ho bokhoni ba eona ba ho nka lintho tse ngata tse hlokahalang bakeng sa metabolism ea lisele.

E 'ngoe ea melemo ea pinocytosis ke ho feto-fetoha ha maemo ho ikamahanya le maemo a fapaneng le liphetoho ho tikoloho. Lisele li ka ntšetsa pele tšebetso ena, li lumella ho monya limatlafatsi nakong ea lijo tse ngata kapa tse haellang. Ho feta moo, pinocytosis ha e amehe ke bongata ba limatlafatsi bohareng, kaha e khona ho hapa limolek'hule leha e le maemong a tlase. Sena se bohlokoa ka ho khetheha maemong a khaello moo lisele li tlamehang ho sebelisa limatlafatsi tse teng ka botlalo.

Pinocytosis e boetse e bapala karolo ea bohlokoa ho laola ho leka-lekana ha metsi le electrolyte 'meleng. Ka ho ts'oaroa ha mokelikeli oa extracellular, lisele li ka boloka homeostasis le ho thibela ho se leka-lekane ha osmotic. Matla ana a taolo a bohlokoa bakeng sa ho phela ha lisele le tšebetso e nepahetseng ea lisele le litho tsa 'mele. Ka bokhutšoanyane, pinocytosis ha e bohlokoa feela bakeng sa ho fumana limatlafatsi, empa hape le ho laola mekhoa ea bohlokoa ea 'mele.

Lintlha tse amang katleho le taolo ea pinocytosis phepelong ea lisele

Likopo le bohlokoa ba baeloji ea pinocytosis lits'ebetsong tse fapaneng tsa cellular

Pinocytosis ke ts'ebetso ea bohlokoa ea tlhaho e etsahalang litsamaisong tse fapaneng liselefouno. Mofuta ona oa endocytosis o lumella lisele ho monya maro le likaroloana tse qhibilihisitsoeng ho tsoa tikolohong e kantle ho sele, ho thusa ho monya limatlafatsi, ho tlosa litšila, le ho nchafatsa lera.

Lefapheng la bongaka, pinocytosis e bapala karolo e loketseng ho tsamaiseng lithethefatsi le liphekolo tse khethehileng ho lebisa liseleng. Ka ho fetola li-nanoparticles tse nang le limolek'hule tse lumellanang le lintho tse phelang, hoa khoneha ho finyella katleho e kholo ho fana le ho ba teng ha lithethefatsi ho phekola mafu a kang kankere kapa mafu a lefutso.

Ho feta moo, pinocytosis e bapala karolo ea bohlokoa ho monyeng ha limatlafatsi ka maleng a manyane. Lisele tsa epithelial tse tsamaisanang le mala li etsa pinocytosis ho tšoara limolek'hule ea lijo le ho nolofatsa ho monya ha eona ka lera la mala. Ts'ebetso ena ke ea bohlokoa ho boloka tekano ea phepo e nepahetseng 'meleng le ho khothalletsa ts'ebetso e nepahetseng ea tsamaiso ea lijo.

Lintlha tse sebetsang le tsa tekheniki bakeng sa ho ithuta ho fepa ka cellular ka pinocytosis

Pinocytosis ke ts'ebetso ea bohlokoa phepong ea cellular e kenyelletsang ho hapa le ho monya maro le limolek'hule tse qhibilihang ho pholletsa le lera la sele. Ho ithuta ketsahalo ena ka nepo, ho bohlokoa ho nahana ka likarolo tse ling tse sebetsang le tsa tekheniki tse ka susumetsang sephetho se fumanoeng. Mona ke lintlha tse ling tsa bohlokoa:

• Khetho ea lisele tse loketseng: Pele o etsa liteko tsa pinocytosis, ho bohlokoa ho khetha mohala o loketseng oa sele o tsejoang ka ho bonts'a sekhahla se phahameng sa ts'ebetso ea pinocytosis. Lisele tse sebelisoang haholo bakeng sa lithuto tsena ke lisele tsa epithelial, joalo ka lisele tsa HeLa. Lisele tsena li bonolo ho setso le ho boloka matla a mahlahahlaha a pinocytosis.
• Ho khetha matšoao a nepahetseng: Ho khetholla le ho lekanya pinocytosis, ho hlokahala hore u sebelise matšoao a khethehileng a lumellang hore thepa e nkiloeng e arohane le mehaho ea lisele. Matšoao a fluorescent, joalo ka mokelikeli oa pinocytosis o ngotsoeng ka dae ea fluorescent, e ka ba molemo haholo kaha e lumella li-pinocytosis vesicles ho lateloa le ho bonoa nakong ea ts'ebetso.
• Taolo ea maemo a liteko: Ho bohlokoa ho boloka maemo a liteko a kamehla le a laoloang nakong ea thuto ea pinocytosis. Sena se kenyelletsa mocheso, pH, khatello ea metsi, le nako ea ho incubation. Phapang leha e le efe ea maemo ana e ka ama liphello le tlhaloso ea lintlha tse fumanoeng.

Ho tseba lintlha tse sebetsang le tsa tekheniki tsa bohlokoa bakeng sa thuto ea cellular pinocytosis ho tla lumella ho fumana liphetho tse tšepahalang le tse ka hlahisoang hape. Ho feta moo, lintlha tsena li fana ka motheo o tiileng oa lipatlisiso tsa nako e tlang lefapheng la phepo ea cellular le moelelo oa eona ho physiology ea cellular. Ke habohlokoa ho hlokomela hore thuto e 'ngoe le e' ngoe e ka hloka liphetoho tse itseng ho itšetlehile ka mofuta oa sele le sepheo sa lipatlisiso, empa melao-motheo ena e akaretsang e tla thusa ho theha motheo oa thuto e atlehileng ea pinocytosis tabeng ea ho fepa ka lisele.

Mathata a amanang le phetoho kapa ho se sebetse ha pinocytosis maemong a phepo ea cellular

Pinocytosis ke ts'ebetso ea bohlokoa phepong ea cellular e lumellang ho monya metsi le likaroloana tse qhibilihang ka ho theha li-vesicles. Leha ho le joalo, ho fetoha ha eona kapa ho se sebetse ho ka lebisa mathateng a bohlokoa seleng. E 'ngoe ea litšitiso tse kholo tse amanang le phetoho ena ke khaello ea limatlafatsi tse hlokahalang bakeng sa ts'ebetso e nepahetseng ea sele. Ntle le ts'ebetso e lekaneng ea pinocytosis, sele e ke ke ea khona ho hapa le ho monya limatlafatsi tse hlokahalang bakeng sa ho phela le nts'etsopele ea eona.

Bothata bo bong bo amanang le pinocytosis e senyehileng ke ho bokella litšila le chefo ka seleng. Haeba pinocytosis e sa sebetse hantle, sele e ke ke ea khona ho felisa litšila le lintho tse chefo tikolohong ea eona. Litšila tsena li ka bokellana ka har'a sele, e leng se senyang ts'ebetso ea eona 'me e ka lebisa ponahalong ea mafu.

Ho feta moo, tšitiso ea pinocytosis le eona e ka ama puisano ea sele-to-cell. Ts'ebetso ena e bohlokoa bakeng sa phetiso ea matšoao le khokahano lipakeng tsa lisele tse fapaneng tsa lesela kapa setho. Haeba pinocytosis e fetoloa, sele e ke ke ea khona ho fumana matšoao a lekaneng a tsoang tikolohong ea eona, e leng se ka lebisang ho se leka-lekaneng le mathata 'meleng.

Kamano lipakeng tsa pinocytosis le litsela tse ling tsa ho tsamaisa limatlafatsi liseleng

Ho na le litsela tse fapaneng tsa ho tsamaisa limatlafatsi liseleng, 'me pinocytosis ke e' ngoe ea tsona. Leha e na le litšobotsi tse fapaneng, kamano lipakeng tsa pinocytosis le litsela tsena tse ling e bohlokoa haholo bakeng sa ts'ebetso e nepahetseng ea lisele.

Ntlha ea pele, pinocytosis e arolelana lintho tse tšoanang le endocytosis ea li-receptor, kaha ka bobeli li kenyelletsa ho thehoa ha li-vesicles ho tloha lera la sele. Leha ho le joalo, ho fapana le endocytosis ea li-receptor-mediated, pinocytosis ha e hloke li-membrane tse khethehileng bakeng sa ho kenngoa ha likaroloana. Kamano ena e re lumella ho utloisisa ho tlatsana lipakeng tsa litsela tsena ka bobeli, kaha endocytosis ea li-receptor-mediated e na le boikarabello ba ho hapa limolek'hule tse itseng ha pinocytosis e ntse e akaretsa haholoanyane tseleng ea ho hapa likaroloana.

Ho phaella moo, pinocytosis e boetse e amana le seo ho thoeng ke exocytosis, moo lisele li lokollang lintho ka har'a extracellular medium. Leha li ka bonahala e le lits'ebetso tse fapaneng, pinocytosis e bapala karolo ea bohlokoa taolong ea exocytosis. Nakong ea pinocytosis, li-vesicles tsa limatlafatsi tse hapiloeng li ka fetisetsoa litseleng tsa ho tsosolosa kapa likarolong tsa polokelo ea intracellular, tse kang li-lysosomes. Ka mor'a moo, likarolo tsena li ka kopanya le lera la sele ho lokolla likahare tsa tsona ho extracellular medium ka exocytosis.

Bohlokoa ba ho ja lijo tse leka-lekaneng ho ntlafatsa pinocytosis liseleng

Lijo tse leka-lekaneng li bapala karolo ea bohlokoa ho ntlafatseng pinocytosis liseleng. Pinocytosis ke ts'ebetso eo lisele li monyang maro le limolek'hule tse qhibilihang tikolohong ea tsona. Ho etsa bonnete ba hore ts'ebetso ena e sebetsa hantle, ho bohlokoa ho fa 'mele limatlafatsi tse lekaneng.

Ho kenngoa ha protheine ho bohlokoa bakeng sa pinocytosis. Liprotheine ke karolo ea li-membrane receptors tse lumellang ho lemoha le ho kenngoa ka hare ho limolek'hule tseo lisele li li hlokang bakeng sa ho sebetsa ha tsona. Ka ho kenyelletsa palo e lekaneng ea protheine lijong tsa rona tsa letsatsi le letsatsi, re netefatsa sebopeho le ts'ebetso e lekaneng ea li-receptor tsena, ka hona ho ntlafatsa pinocytosis.

Ntho e 'ngoe ea bohlokoa ea ho ja lijo tse leka-lekaneng ho ntlafatsa pinocytosis ke ho ja livithamine le liminerale. Limatlafatsi tsena lia hlokahala bakeng sa ts'ebetso e nepahetseng ea li-enzyme le li-cofactors tse amehang ts'ebetsong ea ho monya le ho kenya liseleng. Li-vithamine tse kang vithamine C le E, hammoho le liminerale tse kang zinki le tšepe, li bapala karolo ea bohlokoa ho boloka pinocytosis e sebetsa hantle. Ho netefatsa hore re kenyelletsa limatlafatsi tsena lijong tsa rona tsa letsatsi le letsatsi ho bohlokoa ho matlafatsa bokhoni ba lisele ho etsa pinocytosis hantle.

Litlhahiso tsa ntlafatso le taolo ea pinocytosis ho fepa ka cellular

Ntlafatso ea kholiso ea limatlafatsi: Ho ntlafatsa le ho laola pinocytosis phepelong ea lisele, ho bohlokoa ho netefatsa hore ho na le limatlafatsi tse lekaneng sebakeng sa extracellular. Ho etsa sena, ho kgothaletswa ho etsa tlhahlobo ea nako le nako ea limatlafatsi (tse kang tsoekere, li-amino acid, livithamine, joalo-joalo) tse teng moetlong oa setso, 'me u lokise mahloriso a tsona ho itšetlehile ka litlhoko tsa lisele. Ho boloka motsoako o nepahetseng oa limatlafatsi ho tla khothaletsa katleho e kholo ts'ebetsong ea pinocytosis, e leng ho lumellang ho ja limatlafatsi tse ngata le ts'ebetso e ntle ea metabolism.

Khothatso ea ts'ebetso ea li-receptor: Ntho e 'ngoe ea bohlokoa ea ho ntlafatsa pinocytosis phepelong ea lisele ke ho susumetsa tšebetso ea li-receptor tse teng lera la sele. Sena se ka finyelloa ho sebelisa li-ligands tse khethehileng tse tlamang li-receptor tsena le ho kenya tšebetsong mosebetsi oa tsona. Mehlala e meng ea li-ligand e ka sebelisoang e kenyelletsa lintlha tsa kholo, lihomone le li-peptide tse itseng. Ka ho eketsa ts'ebetso ea li-receptors, ho ratoa ho thehoa ha lintho tse hlaselang lera la plasma, e leng ho nolofalletsang ho kena ha limolek'hule ka hare ho sele ka mokhoa oa pinocytosis.

Ho laola mekhoa ea endocytosis: Pinocytosis ke e 'ngoe ea mekhoa ea endocytosis e ka hlahang liseleng. Ke habohlokoa ho hlokomela hore ho na le mefuta e meng e 'meli ea endocytosis, phagocytosis le receptor-mediated internalization. Ho laola le ho ntlafatsa pinocytosis ho fepa ka lisele, ho kgothaletswa ho laola ka hloko mekhoa ea endocytosis e teng. Sena se ka finyelloa ka ho khetha ho thibela mekhoa e sa batleheng le ho khanna pinocytosis e le mokhoa o ka sehloohong oa ho kena ha limatlafatsi. Tšebeliso ea li-inhibitors tse khethehileng le ho laola liphatsa tsa lefutso e ka 'na ea e-ba mekhoa e molemo ea ho finyella taolo ena le ho laola pinocytosis ka nepo ho fepa ka lisele.

Maikutlo a bokamoso le tsoelo-pele ea mahlale ea ho utloisisa phepelo ea lisele ka pinocytosis

Mehleng ea baeloji ea limolek'hule le liphatsa tsa lefutso, tsoelo-pele ea saense e re lumelletse ho kena lefatšeng le tsotehang la phepo ea cellular ka pinocytosis. Ha ho ntse ho etsoa liphuputso tse eketsehileng mabapi le mokhoa ona, ho ntse ho hlaha litebello tse tšepisang tsa nako e tlang ’me ho ntse ho sibolloa tse fanang ka leseli mabapi le ho rarahana ha eona.

E 'ngoe ea lintlha tsa bohlokoa thutong ea ho fepa ka cellular ka pinocytosis ke ho tsebahatsa mekhoa e fapaneng e laolang ts'ebetso ena. Ho 'nile ha hlokomeloa hore ho na le liprotheine tse ngata tsa bohlokoa tse amehang ho thehoeng ha li-endocytic vesicles, tse kang clathrin le caveolae, tse phethang karolo ea bohlokoa ho kenya limatlafatsi le limolek'hule tse ling. Ha ho khetholla le ho khetholla ha liprotheine tsena ho ntse ho teba, monyako o bula mekhoa e mecha ea phekolo ea ho phekola maloetse a amanang le bofokoli ba phepo ea cellular.

Khatelo-pele e 'ngoe ea bohlokoa ke tlhahlobo ea likarolo tsa li-endocytic vesicles le tšebelisano ea tsona le lisele tse li amohelang. Ka mekhoa e metle ea li-microscopy le ts'ebetsong ea mekhoa e meholo ea tatellano, ho khonne ho khetholla lipids le liprotheine tse fapaneng tse teng ka har'a li-vesicles tsena, hammoho le litsela tsa matšoao tse laolang ho kopana ha tsona. cytoplasm ea sele. Lintho tsena tse sibolotsoeng li re lumella ho utloisisa hamolemo mekhoa ea metabolic le li-cascades tse laolang phepelo ea lisele ka pinocytosis, ho bula menyetla e mecha bakeng sa nts'etsopele ea liphekolo tse lebisitsoeng le tse etselitsoeng motho ka mong.

Lipotso le Likarabo

P: Ho fepa cell pinocytosis ke eng?
A: Cell feeding pinocytosis ke ts'ebetso ea endocytosis eo lisele li kenyelletsang limolek'hule tse nyane tse qhibilihisitsoeng ka har'a maro a kantle ho sele.

P: Mokhoa oa pinocytosis ke eng?
A: Ho pinocytosis, sele e etsa litlhaselo ka har'a lera la plasma, e etsa li-vesicles tse bitsoang pinosomes. Li-vesicles tsena li koala le ho ikhula lera, li nka mokelikeli le limolek'hule tse qhibilihisitsoeng le tsona.

P: Pinocytosis e sebelisoa neng?
A: Pinocytosis e sebelisoa ho tšoara le ho monya limatlafatsi, tse kang amino acid, tsoekere le lipids, tse teng tikolohong ea extracellular. E boetse e sebelisetsoa ho felisa lihlahisoa tsa litšila le ho laola lik'hemik'hale tsa tikoloho ea lisele.

P: Mekhahlelo ea pinocytosis ke efe?
A: Pinocytosis e na le mekhahlelo e meraro e meholo: ho hlaseloa ha lera la plasma, ho thehoa ha pinocytosis vesicle, le phagocytosis ea ka hare.

P: Ke mefuta efe ea pinocytosis e teng?
A: Mefuta e 'meli ea pinocytosis e tsejoa: macropinocytosis le receptor-mediated pinocytosis. Ho macropinocytosis, sele e kenya mokelikeli o mongata le likaroloana, ha pinocytosis e amohelang li-receptor e lumella ho khethoa ha limolek'hule tse itseng tse tlamang ho li-receptor tse lera.

P: Pinocytosis e fapane joang le phagocytosis?
A: Pinocytosis e fapane le phagocytosis ka boholo ba likaroloana tse hapuoeng le ka mekhoa ea ho hapa e khethehileng. Le hoja phagocytosis e kenyelletsa likaroloana tse kholoanyane 'me e itšetlehile ka ho tlamahanngoa ho khethehileng ha limolek'hule, pinocytosis e shebane le ho kenngoa ha metsi le limolek'hule tse qhibilihisitsoeng.

P: Litlamorao tsa kliniki tsa pinocytosis ke life?
A: Pinocytosis e bapala karolo ea bohlokoa ho monyeng ha limatlafatsi le lithethefatsi, kahoo ho se tloaelehe ha mokhoa ona ho ka ama phepo ea cellular le lipalangoang tsa lithethefatsi. Ho phaella moo, e ka 'na ea ameha mafung a amanang le kabo e sa tloaelehang ea liprotheine' meleng.

P: Na ho na le melaoana ea pinocytosis ka sele?
A: E, pinocytosis e ka laoloa ka boteng le ts'ebetso ea liprotheine tse fapa-fapaneng le lintlha tsa matšoao a intracellular. Mekhoa ena ea taolo e netefatsa ho leka-lekana ho lekaneng ho nkeng le ho lokolloa ha maro le limolek'hule ke sele.

Qeto

Ka kakaretso, pinocytosis ke ts'ebetso ea mantlha ea phepelo ea lisele, moo lisele li jang lintho tse metsi kapa likaroloana tse nyane tse teng tikolohong ea tsona. Ka ho theha li-vesicles, sele e khona ho hapa le ho tsamaisa lintho tsena ho cytoplasm ea eona bakeng sa ts'ebetso e latelang. Mochine ona oa endocytosis o teng liseleng le liseleng tse fapaneng, o bapala karolo ea bohlokoa mesebetsing e kang phepo e nepahetseng, ho itšireletsa mafung le ho felisa litšila. Le hoja pinocytosis e ntse e hlahisa lipotso tse ngata le liphephetso bakeng sa lipatlisiso tsa saense, thuto ea eona e tsoelang pele e tla re lumella ho utloisisa physiology ea lisele le ho bula mamati a macha ntlafatsong ea phekolo ea meriana le phekolo. Ka hona, ho fepa ka lisele ka pinocytosis ho nkoa e le ntho ea bohlokoa haholo le e rarahaneng, e ntseng e tsoela pele ho khahla bo-rasaense le ho re makatsa ka ts'ebetso e tsotehang ea bophelo boemong ba microscopic.