- I-Perovskite detectors ifezekisa i-single-photon ye-SPECT imaging ngamandla aphezulu kunye nesisombululo sendawo.
- Iindleko eziphantsi kune-CZT kunye nomgangatho ongcono kune-NaI uvule umnyango wokufikelela ngakumbi kunye nokuxilongwa kwedosi ephantsi.
- Efotweni, iipikseli ze-perovskite RGB ezipakishweyo zibamba ukukhanya okuphindwe kathathu ngaphezulu kwesilicon enezihluzi.
- Inkqubela phambili kwimveliso kunye nozinzo ikhawulezisa inguqu esuka kwilabhoratri ukuya kwiimveliso zorhwebo.
Igama elithile "igumbi perovskite» uye watyibilika kwi-radar yezinto ezintsha ngeendlela ezimbini: kwelinye icala, kwiyeza lenyukliya elinezichongi ezikwaziyo ukurekhoda iifotoni zegamma enye nge ukuchaneka okungazange kubonwe ngaphambili; kwelinye icala, kwi Ifoto yedijithali enezinzwa ze-RGB ezipakishweyo ezithembisa ukukhanya okungakumbi kunye nengxolo encinciZombini ezi nkqubela ziphuma kumthombo ofanayo: iipropathi ezingaqhelekanga zeekristale kunye nesakhiwo se-perovskite.
Ezibhedlele, le teknoloji ijolise Nciphisa amaxesha okuskena, phucula ububukhali kwaye unciphise ithamo lemitha kubuchule obufana ne-SPECT; kwihlabathi lemifanekiso, ivula umnyango abenzi boluvo ababamba phantse yonke ispectrum ebonakalayoEmva kwayo kukho amaqela avela kwiYunivesithi yaseNorthwestern kunye neYunivesithi yaseSoochow eChina, kunye nemanyano yeMpa kunye ne-ETH Zurich, ethi Baye babonisa ukusebenza kwerekhodi kunye neeprototypes ezisebenzayo esele zisondele kwintengiso..
Yintoni ikhamera ye-gamma ye-perovskite kwaye isebenza njani i-SPECT?
En INTETHO (ukukhutshwa kwefoton enye kwikhompyuter ye-tomography) i-radiotracer yexesha elifutshane ifakwe emzimbeni; ukukhutshwa kwayo kwe-gamma kudlula kwiithishu kwaye kubanjwe ngumtshina wangaphandle ophinda wakhe umsebenzi we-organic kwi-3D, ngokungathi ikhamera "engabonakaliyo".. Isetyenziselwa Vavanya ukusebenza kwentliziyo, ukuhamba kwegazi, okanye ukulimala okungaboniswanga kwezinye iimvavanyo.
Umtsi ufika xa umtshina uyeka ukuba ngumqobo. Iqela laseMntla-ntshona kunye neSoochow lityhila i-perovskite detector yokuqala ekwaziyo ukubamba iifoto ze-gamma nganye nganye ngamandla aphezulu kunye nesisombululo sendawo, ilungiselelwe umfanekiso weSPECTIpapashwe kuNxibelelwano lweNdalo, lo msebenzi wenza ukuba kube yinyani into eyayisisithembiso kwiminyaka elishumi eyadlulayo: ukuba i-perovskites Kwakhona babekwazi ukubona iiX-reyi neegamma ray ukongezelela kumandla elanga..
Isitshixo silele kwi-sensor "pixelated"-i-matrix efana neepikseli kwikhamera yeselula-eyenziwe kwiikristale eziphezulu ze-perovskite. Ngoyilo lwe-elektroniki olulungiswe kakuhle lwamajelo amaninzi, iprototype ibonisa uzinzo olugqwesileyo kunye novakalelo olukwaziyo ukucudisa ngaphandle imiqondiso ebuthathaka kakhulu yezonyango radiopharmaceuticals ezifana technetium-99mOlu lwakhiwo luguqula ifoton nganye ibe yicocekile, ingcaciso echane ngakumbi.
Kwisigulane, iimpembelelo zithe ngqo: amaxesha amafutshane eskena, imifanekiso ebukhali, kunye nokwenzeka kokunciphisa umthamo. Ukusuka kwimbono yeenkqubo, ukukwazi ukwahlula amandla e-gamma ngokuchanekileyo okukhulu ivula ucango olutyebileyo lwe-dimensional-dimensional reconstruction kunye nezicelo ezintsha zokuxilonga apho ukukhetha kwamandla kwenza umahluko.
Uphononongo luye lwafumana inkxaso ephezulu yeziko kunye nemali-kuquka i-Arhente yokuNcitshiswa kweNgcingo yoKhuselo (HDTRA12020002), iinkqubo zelizwe e-China, kunye neziseko zommandla-kunye. Iboniswa njengenyathelo elibalulekileyo lokwamkelwa ekliniki. Kwabo bafuna ukulandelela ireferensi echanekileyo, inqaku livela ukufikelela okuvulelekileyo kuNxibelelwano lweNdalo (DOI: 10.1038/s41467-025-63400-7).
Kutheni ii-detectors zemveli zisilela
Uninzi lweekhamera zekliniki zegamma zisebenzisa iikristale ze CdZnTe (CZT) okanye iodide yesodium (NaI). I-CZTs inokufikelela kwisisombululo esiphezulu kakhulu, kodwa isithende sabo se-Achilles yindleko kunye ne-fragility: ukukhula okukhulu, iikristale ezikumgangatho ophezulu ziyinkimbinkimbi kwaye ziyabiza, ukuphakamisa ixabiso ngeyunithi nganye ukuya kumakhulu amawaka okanye izigidi zeerandi, kwaye inzuzo eyongeziweyo kukuba zizinto ezinqabileyo.
I-NaI, ngakolunye uhlangothi, yenza inkqubo ingabizi, kodwa ngeendleko zevolumu kunye nobukhali: imifanekiso ilahlekelwa yinkcukacha kunye nokwahlukileyo, njengokungathi sijonge ngeglasi. ingcolisiweOku kuncipha kokuchaneka kubangela ukuhluka okufihlakeleyo kokusebenza kwengqondo ukuba kube mfiliba, kube nzima ukuxilonga kwangaphambili okanye okwahlukileyo, umzekelo kwiintlobo zesifo sengqondo esiyingozi kunye neepateni ezahlukeneyo zokuxilisa.
Kuzo zombini ezi meko, i-equation yokugqibela ayidibanisi ncam: mhlawumbi uhlawula ngakumbi umgangatho kunye nokunciphisa imveliso yobuso, okanye wonge ngokuncama isisombululo. Esi sikhewu ukuba ii-detectors ezisekelwe kwi-perovskite ziza ukuzalisa, zinika indibaniselwano engaqhelekanga ukusebenza kunye nokufikeleleka.
Umgangatho wokutsiba: iiperovskites kumayeza enyukliya
Iiperovskites zi usapho lwecrystalline ogama livela kwiminerali enesakhiwo seCaTiO3kodwa Namhlanje iquka izixhobo ezinejometri efanayo -kuquka i-lead halides- eziye zaguqula i-photovoltaicsKwi-2012, iqela laseNyakatho-ntshona libonise iiseli zelanga zokuqala eziqinileyo-ifilimu ye-perovskite; emva konyaka, bakungqina oko iikristale enye I-perovskites ifumene ii-X-ray kunye ne-gamma ray ngokufanelekileyo, ukuvula indawo yophando ekhule kumazwe ngamazwe.
Ukusukela ngoko, Ukukhula kwekristale kunye nobuchwephesha bobunjineli bomphezulu benziwe bugqibelele ukuguqula loo nto inokwenzeka ibe zizixhobo zokwenyani.Umtshina omtsha udibanisa uluhlu lwepikseli ye-perovskite, ukufundwa kwamajelo amaninzi, kunye nemeko enciphisa ilahleko kunye nokuphazamiseka. Isiphumo kukuba Imifanekiso eyahlula imithombo ye-radioactive eyahlulwe ngeemilimitha nje kunye novakalelo olukwaziyo ukubona imiqondiso ebuthathaka kakhulu esetyenziswa rhoqo Tc-99m.
Enye yezinto ezibonakalayo, ihalide CSPbBr3, Ibonisa iimpawu zombane kunye nezothutho eziyimfuneko kolu hlobo lwezinzwaNgayo, ukukwazi ukucalula amandla e-gamma kuguqulela umahluko ongcono phakathi kwezicubu okanye iinkqubo ze-physiological kunye neesignesha ezahlukeneyo. Olu khetho lwamandla luvumela ulwazi oluninzi ukuba lukhutshwe kwifoton nganye efunyenweyo.
Ngaphandle kobukhali, isixhobo sigcina uzinzo olumangalisayo: Ibamba phantse lonke ubalo lomkhondo ngaphandle kwelahleko encomekayo okanye ukugqwetheka ngexesha lovavanyoOku komelela okusebenzayo ngundoqo ekudityanisweni kwayo kwixesha elizayo kwiinkqubo zeklinikhi ezinomsebenzi onzima kunye neemfuno ezizinzileyo zokulinganisa.
Iingenelo eziluncedo zicacile. Ngezichongi ezinovakalelo ngakumbi, amaxesha okuskena okanye iidosi ezilawulwayo zinokuncitshiswa ngaphandle kokuncama umgangathoKwaye ngokukwazi ukuzakha ngeenkqubo ezilula kunye namacandelo kunee-CZT, iindleko ziyathotywa, kuvula indlela yokuba izixhobo eziphucukileyo zifike ezibhedlele nakwiikliniki ezingakwaziyo ukufikelela ngoku kubuchwephesha bamvanje.
Impembelelo yokwenyani, iindleko kunye nokuthengisa
UMntla-ntshona uqalise i-spin-off, i-Actinia Inc., ukuzisa obu buchwepheshe kwilebhu ukuya kwimarike, ngokusebenzisana nabavelisi bezixhobo zonyango. Injongo kukuphumeza iikhamera zegamma ezihlangeneyo, ezichanekileyo nezifikelelekayo, eyandisa ukufikelela kwi-diagnostics ephezulu ngaphandle kokwenza ixabiso libe ngumqobo.
Xa kuthelekiswa ne-NaI, i-perovskite detectors Banikezela ngendlela eyinyani yokusebenza ngamadosi erediyotracer asezantsi ngaphandle kokulahlekelwa sisisombululo.. Phambi kweCZT, bathembisa a Ityala eliphantsi kakhulu kunye nenkqubo yokwenziwa ebuthathaka kancinci, ukugcina amandla omfanekiso kwinqanaba le-photon kwaye ligqwesileyo isisombululo samandlaIndibaniselwano yokusebenza kunye neendleko yiyo eyenza esi siphakamiso siphazamise.
Kugqirha, oku kuguqulela ekubeni kunokwenzeka ukulungelelanisa iprotocol: Xa iinkcukacha eziphezulu zifuneka, ikhamera iyaphendula; Xa umgangatho osemgangathweni wanele, isantya okanye umgangatho unokubekwa phambili. ukunciphisa ukuba sesichengeni kwesigulanaKwizifo ze-oncological okanye ezosulelayo-apho iimviwo eziphezulu zamandla zixhaphakile-le ndlela yokuphumla ibaluleke kakhulu.
Ukuqinisekiswa kovavanyo lweprototype kubonisa ukwahlulwa kwemithombo emincinci yeradioactive ebekwe iimilimitha ezimbalwa ngaphandle, into iphucula uvavanyo lolawulo lomgangatho kwaye ilungelelanisa ukulindela okunokwenziwa zezi nkqubo Sombulula kwi vivo. Ukongeza kwisakhono sokucalula amandla, yenza isiseko seendlela eziphambili ngakumbi kwi-SPECT ngokwayo.
Ndingumntu othanda itekhnoloji ojike umdla wakhe we "geek" waba ngumsebenzi. Ndichithe ngaphezulu kweminyaka eli-10 yobomi bam ndisebenzisa itekhnoloji yokusika kwaye ndikhenkceza ngazo zonke iintlobo zeenkqubo ngenxa yokufuna ukwazi okumsulwa. Ngoku ndiqeqeshelwe ubugcisa bekhompyutha nakwimidlalo yevidiyo. Oku kungenxa yokuba ngaphezu kweminyaka emi-5 ndibhalela iiwebhusayithi ezahlukeneyo kwitekhnoloji kunye nemidlalo yevidiyo, ndisenza amanqaku afuna ukukunika ulwazi oludingayo ngolwimi oluqondakalayo kuye wonke umntu.
Ukuba unayo nayiphi na imibuzo, ulwazi lwam lusuka kuyo yonke into enxulumene nenkqubo yokusebenza yeWindows kunye ne-Android yeefowuni eziphathwayo. Kwaye ukuzinikela kwam kukuwe, ndihlala ndikulungele ukuchitha imizuzu embalwa kwaye ndikuncede usombulule nayiphi na imibuzo onokuba nayo kweli lizwe le-intanethi.