Steatosis yeselula

⁢ I-Cellular steatosis, ekwabizwa ngokuba yi-hepatic steatosis okanye isibindi esinamafutha, yimeko apho isibindi sinokuqokelelana kwamafutha kwiiseli zaso. Le meko, enokuthi yenzeke kubantu abadala kunye nabantwana, ibonakala ngokuguqulwa kwemetabolism ebangela ukungalingani kwi-lipid regulation. Kweli nqaku, siza kuphonononga eyona miba iphambili ye-steatosis yeselula, kubandakanya i-etiology, iimpawu, ukuxilongwa kunye nonyango olunokwenzeka. Ngombono wobugcisa kunye nethoni engathathi hlangothi, siya kuhlalutya le pathology ngenjongo yokubonelela ngolwazi oluchanekileyo kunye olupheleleyo malunga ne-cellular steatosis.

Izizathu ze-steatosis yeselula

I-steatosis yeselula yenzeka xa iiseli zomzimba ziqokelela amanqatha amaninzi. Le ngqokelela ingenzeka kumalungu ahlukeneyo anjengesibindi, intliziyo okanye izintso, kwaye inokubangelwa zizinto ezahlukeneyo. Ngezantsi zezinye eziphambili:

Ubunzima obugqithisileyo kunye nokutyeba: Ukutyeba kwamafutha amaninzi kuhambelana ngokuthe ngqo ne-cellular steatosis. Iiseli ze-Adipose zigcwalisa i-lipids kunye neeseli kwamanye amalungu nazo zinokugcina amanqatha kwiimali ezingaqhelekanga.

– Ukusetyenziswa kotywala ngokugqithisileyo: Utywala bunetyhefu esibindini kwaye bunokukhokelela ekuqokeleleni kwamafutha kweli lungu. Isibindi sinoxanduva lokusebenzisa utywala, kodwa xa sisetyenziswe ngokugqithisileyo, le nkqubo kuphazamiseka kwaye ukungalingani kwenzeka kwi-lipid metabolism.

-⁢ Isifo seswekile kunye nokunganyangeki kwe-insulin: Uhlobo lwe-2 yeswekile kunye nokuxhathisa kwe-insulin kunxulumene ngokusondeleyo ne-cellular steatosis. Ukumelana ne-insulin kuthintela iiseli ekusebenziseni ngokufanelekileyo i-glucose, ekhokelela isibindi ukuvelisa amanqatha amaninzi kwaye siwaqokelele.

Imiba yomngcipheko enxulumene ne-steatosis yeselula

I-Cellular steatosis, ekwabizwa ngokuba yi-fatty liver, yimeko apho iiseli zesibindi ziqokelela amanqatha amaninzi. Esi sifo sinokuba nemingcipheko eyahlukeneyo enxulumene nayo, ekufuneka ithathelwe ingqalelo ukuthintela ukukhula okanye ukuqhubela phambili kwayo. Apha ngezantsi zezinye zezona zinto ziqhelekileyo zomngcipheko:

1. Ukutyeba: Ukutyeba ngowona mngcipheko uphambili wokuphuhlisa i-steatosis yeselula. Ubunzima obuninzi ⁤ bunokunyusa ukuqokelela kwamafutha esibindi, okwenza kube nzima ukuba usebenze ngokufanelekileyo. Kubalulekile ukwamkela indlela yokuphila esempilweni, kunye nokutya okunesondlo kunye nokuzilolonga rhoqo, ukuthintela ukutyeba kakhulu kunye neengxaki ezinxulumene noko.

2. Uhlobo lwesi-2 seswekile: Abantu abanesifo sikashukela sohlobo lwe-2 banomngcipheko owongezelelweyo wokuphuhlisa i-steatosis yeselula. Oku kungenxa yokuba ukumelana ne-insulin, uphawu lwesi sifo, kunokuchaphazela i-fat metabolism esibindini. Ukuthintela i-steatosis yeselula kubantu abanesifo seswekile, kuyimfuneko ukugcina ulawulo olwaneleyo lwamanqanaba eswekile yegazi kwaye ulandele imiyalelo yezonyango yokulawula isifo seswekile.

3. Ukusela utywala ngokugqithisileyo: Ukusetyenziswa kotywala ngokugqithiseleyo kunokuba ngumngcipheko obalulekileyo wokuphuhliswa kwe-cellular steatosis. Utywala buyi-metabolized kwisibindi kwaye ukusetyenziswa kakubi okungapheliyo kunokukhokelela ekuqokeleleni kwamafutha kwiiseli zesibindi. Ukunciphisa okanye ukuphepha ngokupheleleyo ukusetyenziswa kotywala kubalulekile ukukhusela impilo yesibindi kunye nokukhusela ukuqala kwesi sifo.

Iindlela zePathological ezibandakanyekayo kwi-cellular steatosis

I-Cellular steatosis sisifo se-pathological esibonakaliswa kukuqokelelwa okungaqhelekanga kweelipids kwiiseli, ngakumbi i-hepatocytes. Le meko inokubangelwa ngeendlela ezahlukeneyo, ezinokunyusa umngcipheko wezifo ezinzulu zesibindi. Phakathi kwabo, ezi zilandelayo zibalaseleyo:

• Dyslipidemia: Ukungalingani kumanqanaba e-lipid yegazi kunokukhokelela ekuqokeleleni kwamafutha amaninzi kwiiseli zesibindi. I-Triglycerides kunye ne-cholesterol ziqokelela ngendlela yamaconsi amanqatha, ukuguqula umsebenzi oqhelekileyo weeseli.
• Uxinzelelo lweOxidative: Uxinzelelo lwe-oxidative oluvela kwimveliso egqithisileyo yeentlobo ze-oksijini ezisebenzayo zingonakalisa iiseli zeseli kunye ne-mitochondria. ngokufanelekileyo.
• Ukumelana ne-insulin: Ukunganyangeki kwe-insulin kuthintela amandla eeseli ekubambeni kunye ne-metabolize glucose. Ngenxa yoko, i-glucose engaphezulu iguqulwa ibe ngamanqatha kwaye iqokelele kwi-hepatocytes, igalelo ngakumbi kwi-steatosis.

Ezi ndlela ze-pathological ziyakwazi ukusebenzisana, ukudala umjikelezo onobuqhetseba oqhubela phambili ukuqokelela kwe-lipids kwiiseli zesibindi. Ngaphaya koko, i-cellular steatosis inokuqalisa iinkqubo zokudumba kunye ne-fibrosis, ikhuthaza ukuqhubela phambili kwisifo sesibindi esinamafutha (NAFLD) okanye i-cirrhosis.

Ukuqonda iindlela ezisisiseko ze-pathological ezibandakanyekayo kwi-cell steatosis kubalulekile kuphuhliso lwezicwangciso zonyango ezisebenzayo zokuthintela kunye nokunyanga izifo zesibindi ezinxulumene nokuqokelelwa kwe-lipid. ⁤Uphando lwexesha elizayo olujolise ekutyhileni iinkqubo ezintsonkothileyo zemolekyuli ezibandakanyekayo⁤ le meko ibalulekile ekuphuculeni iziphumo zesigulana ⁤ kunye nokunciphisa umthwalo wokuphazamiseka kwesibindi.

Ukubonakaliswa kweklinikhi ye-cellular steatosis

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I-Cellular steatosis, ekwabizwa ngokuba sisifo sesibindi esinamafutha, yimeko yonyango ebonakaliswa kukuqokelelana kwamafutha kwiiseli zesibindi. Oku kuqokelelwa kwamafutha kunokuba neempawu ezahlukeneyo zeklinikhi, ezinokubandakanya ezi mpawu zilandelayo:

• Iintlungu zesisu: Abantu abaninzi abane-cellular steatosis bafumana intlungu okanye ukungahambi kakuhle kwindawo yesisu, enokuthi ihluke ngamandla kunye nobude.
• Ubunzima bobunzima: I-steatosis yeselula ingakhokelela ekufumaneni ubunzima obungachazwanga, ngenxa yokuqokelelwa kwamafutha kwisibindi kunye nokuguqulwa okunokwenzeka kwimetabolism.
• I-malaise ngokubanzi: Abanye abantu banokuba nemvakalelo ye-malaise ngokubanzi, ukudinwa okanye ukudinwa rhoqo, ngaphandle kwesizathu esicacileyo.
• Utshintsho kwiimvavanyo zegazi: Amanqanaba e-enzymes yesibindi, njenge-alanine aminotransferase (ALT) kunye ne-aspartate aminotransferase (AST), inokuphakanyiswa kubantu abane-cellular steatosis.

Ukongeza, kubalulekile ukukhumbula ukuba i-steatosis yeselula inokuba yi-asymptomatic kumanqanaba ayo okuqala kwaye ifunyenwe kuphela ngovavanyo lwezonyango okanye izikena zokuxilonga. Uxilongo oluchanekileyo ngovavanyo lwegazi, iimvavanyo zemifanekiso, kwaye, kwezinye iimeko, i-biopsy yesibindi ibalulekile ukuvavanya ubungqongqo besi sifo kwaye kumiselwe eyona ndlela yonyango ilungileyo. Ukuba ufumana nayiphi na yezi mpawu okanye unenkxalabo malunga nempilo yesibindi sakho, kuyacetyiswa ukuba ubone ugqirha malunga novavanyo olufanelekileyo.

Ukuxilongwa ngokuchanekileyo kwe-cellular steatosis

I-cell steatosis,⁢ ekwaziwa njengesibindi esinamafutha, yimeko yezonyango apho amanqatha aqokelelana kwiiseli zesibindi. ⁣ Ukwenza uxilongo oluchanekileyo lwesi sifo, uphononongo olucokisekileyo luyafuneka olubandakanya iimvavanyo ezahlukeneyo kunye nobuchule obukhethekileyo.

Enye yezona ndlela zixhaphakileyo zokufumanisa i-steatosis yeselula kukusebenzisa i-biopsy yesibindi. Ngethuba le nkqubo, isampuli encinci yezicubu zesibindi iyasuswa kwaye emva koko ihlalutywe kwibhubhoratri. Ugqirha ujonga ubukho bamafutha aqokelelweyo kwiiseli kwaye uvavanya iqondo lokuvuvukala. I-biopsy ivumela ukuba sifumane iinkcukacha ezicacileyo malunga nemeko yesibindi kwaye ithathwa njengesixhobo esichanekileyo sokuxilonga.

Enye indlela yokufumanisa i-steatosis yeselula kukusebenzisa iimvavanyo ze-imaging, ezifana ne-magnetic resonance imaging (MRI) okanye i-computed tomography (CT) Ezi ndlela zivumela ukuba kufumaneke imifanekiso ecacileyo yesibindi, ebonisa ubukho bamafutha iiseli. Ukongezelela, imilinganiselo echanekileyo yeqondo le-steatosis inokwenziwa, enceda ukufumanisa ubunzima besifo. Olu vavanyo luluncedo kakhulu kwizigulane ezingakwaziyo ukwenza i-biopsy okanye kwiimeko apho uvavanyo lokuqala olukhawulezayo lufuneka.

Uvavanyo lobukhali be-cellular steatosis

Kubalulekile ukuqonda ⁢inqanaba lokuqokelelwa kwamafutha kwiiseli zesibindi. Kukho iindlela ezahlukeneyo zokwenza olu vavanyo, kwaye nganye kuzo inika ulwazi oluxabisekileyo malunga nokuxilongwa kunye nokubeka iliso kwizifo ezifana ne-non-alcoholic steatohepatitis (NASH) kunye nesifo sesibindi esingenalo utywala (NAFLD).

Enye yeendlela ezisetyenziswa kakhulu zokuvavanya ubungqongqo be-cellular steatosis luhlalutyo lwe-histological lwe-biopsy yesibindi. Le nkqubo ibandakanya ukutsalwa kwesampuli yezicubu zesibindi ezihlalutywa kwibhubhoratri ekhethekileyo. Uhlalutyo lwe-Histological luvumela ukujonga ngokuchanekileyo utshintsho kwiiseli zesibindi kunye nokumisela iqondo le-steatosis. Umlinganiselo wokulinganisa usetyenziselwa ukwahlula amanqanaba e-steatosis, ukusuka ku-0 (akukho steatosis) ukuya kwi-3 (i-steatosis enzima).

Enye indlela esetyenziswa ngokuqhelekileyo yi-magnetic resonance imaging (MRI) evaluation. I-MRI inikezela ngemifanekiso ecacileyo yesibindi, evumela ukuqokelelwa kwamafutha kwiiseli zesibindi ukuba zichongwe kwaye zilinganiswe. Obu buchwephesha bunokuhlasela kancinci kune-biopsy yesibindi, buyenza ibe nomtsalane ngakumbi kwezinye izigulana. Ukongezelela,⁤ I-MRI ingaba luncedo ekuhlukaniseni phakathi kwe-steatosis elula kunye ne-NASH, njengoko inokutyhila ubukho bokuvuvukala okanye i-fibrosis esibindi.

• Umlinganiselo wesalathisi se-hepatic steatosis usebenzisa umfanekiso.
• Uhlalutyo lwemolekyuli yokuvavanya ukubonakaliswa kwemfuza enxulumene ne-steatosis.
• Izindlela ezingabonakaliyo, ezifana ne-elastography yesibindi, i-proton MRI, kunye nobuchule be-FibroScan®, nazo zibonise iziphumo ezithembisayo ⁤.

Ngamafutshane, kubalulekile ukumisela impembelelo⁤ ukuba ukuqokelelwa kwamafutha kuye⁤ kwisibindi. Zombini i-biopsy yesibindi, i-imaging kunye neendlela ezingenayo i-invasive zizixhobo ezibalulekileyo kule nkqubo yovavanyo. Ukukhethwa kwendlela kuya kuxhomekeka kwiimfuno ezithile zesigulane kunye nokufumaneka kwezixhobo zobugcisa. ⁢Ukudityaniswa kweendlela ezininzi⁢ kunokubonelela ngembono epheleleyo nechanekileyo yobuzaza be-cell steatosis kwaye incede ekuxilongeni nasekulawuleni izifo zesibindi ezinxulumene ne-steatosis.

Unyango olusebenzayo kwi-cellular steatosis

I-Cellular steatosis yimeko yonyango apho iiseli zesibindi ziqokelelana ngamafutha angaphezulu. Le meko inokubangela ukonakala kwesibindi kwaye, kwiimeko ezinzima, kude kube ne-cirrhosis. Ngethamsanqa, kukho unyango olusebenzayo olunokunceda ukubuyisela umva i-steatosis yeselula kunye nokuphucula ukusebenza kwesibindi.

Olona nyango lucetyiswayo kukwamkela utshintsho kwindlela yokuphila. Olu hlengahlengiso lubandakanya ukwenza umthambo rhoqo, ukutya ukutya okunesondlo okunesondlo, ukunciphisa ukuselwa kotywala, nokuphepha ukutya okusele kugalelwe ngamafutha achumileyo. Ukongezelela, kubalulekile ukugcina ubunzima bomzimba obunempilo kunye nokulawula amanqanaba eswekile yegazi, ngakumbi kubantu abanesifo seswekile.

Olunye unyango olusebenzayo kwi-cellular steatosis kukusetyenziswa kwamayeza. Amayeza amiselwe ngugqirha anokunceda ukunciphisa amanqatha aqokelelweyo esibindini kunye nokuphucula umsebenzi wawo. Eminye imizekelo Amayeza aqhelekileyo aquka i-bile acids, enceda ukugaya amafutha; isibindi se-stabilizers, esinciphisa ukuvuvukala kunye nokukhusela isibindi kumonakalo omkhulu; kunye ne-insulin-sensitizing agents, ezinceda ukulawula i-glucose metabolism⁢ esibindini.

Ukutya okucetyiswayo kunye neNdlela yokuPhila yeCellular Steatosis

Indlela yokutya kunye nendlela yokuphila ecetyiswayo kwi-cellular steatosis ibaluleke kakhulu ekwehliseni ukuqokelelwa kwamafutha kwiiseli zesibindi kunye nokuphucula impilo yesibindi. Nangona umntu ngamnye enokuba nezidingo ezithile zokutya, nazi ezinye iingcebiso ngokubanzi ezinokunceda ukulwa nale meko:

1. Ukutya okulinganayo:

• Yitya iintlobo ngeentlobo zokutya kuwo onke amaqela okutya, kuquka iziqhamo, imifuno, ukutya okuziinkozo, iiproteni ezibhityileyo, kunye namafutha asempilweni.
• Nciphisa ukuthathwa kokutya okucutshulweyo, okutyebileyo ngamafutha ahluthisiweyo kunye nanamafutha agqithisiweyo.
• Ukwandisa ukufakwa kokutya okutyebileyo kwifiber, okufana nemifuno, iziqhamo kunye nemifuno.

2. Ukulawula ubunzima:

• Gcina ubunzima obunempilo ngokwezalathiso zonyango.
• Kuphephe ukutyeba kakhulu kunye nokutyeba, njengoko zingumngcipheko we-steatosis yeselula.
• Zilolonge rhoqo, ubuncinci ⁤150 imizuzu yomsebenzi ophakathi okanye imizuzu engama-75 yomsebenzi onamandla ngeveki.

3. Indlela yokuphila⁢ uhlengahlengiso:

• Nciphisa ukusetyenziswa kotywala, njengoko kunokubangela ukuba i-steatosis yeselula ibe mandundu.
• Kuphephe ukutshaya kunye nezinye izinto eziyityhefu esibindini.
• Lala ngokwaneleyo kwaye ulawule uxinzelelo ngokufanelekileyo.

Kubalulekile ukubalula oko la macebiso Ziqhelekile kwaye zinokwahluka ngokuxhomekeke kwiimfuno zomntu ngamnye. Kuhlala kucetyiswa ukuba udibane nochwepheshe bezempilo, njengogqirha okanye ingcali yezondlo, ukufumana isikhokelo somntu ngokwemeko nganye ethile.

Unyango lweziyobisi kunye nezongezo zeSellular Steatosis

Kukho iindlela ezahlukeneyo zonyango kunye nezongezelelo ezinokunceda kunyango lwe-steatosis yeselula, imeko apho isibindi siqokelela amanqatha angaphezulu. Ezi zikhetho zonyango zinokunceda ukunciphisa ukuvuvukala kunye nokuphucula impilo yonke yesibindi. Ngezantsi lunyango oluxhaphakileyo kunye nezongezo ezisetyenziselwa ukunyanga le meko:

1. Amayeza e-Antidiabetic: Amanye amayeza asetyenziselwa unyango lwesifo sikashukela sohlobo lwe-2, njenge-metformin kunye ne-thiazolidinediones, abonise iinzuzo ezinokuthi zinciphise i-steatosis yeselula. Ezi ziyobisi zinokuphucula ukuvakalelwa kwe-insulin kunye nokunciphisa ukuqokelela kwamafutha esibindi.

2. IiAntioxidants: I-Antioxidants, njenge-vitamin E kunye ne-alpha lipoic acid, isetyenziselwa ukukhusela isibindi kuxinzelelo lwe-oxidative kunye nokunciphisa ukuvuvukala. Ezi zinto zinokunceda ukukhusela umonakalo wesibindi kunye nokukhuthaza ukupheliswa kwamafutha aqokelelwe kwiiseli zesibindi.

3. izongezo zeOmega-3: I-Omega-3 fatty acids, ekhoyo⁢ ekutyeni okufana nentlanzi kunye namandongomane, ibonise iziphumo eziluncedo kunyango lwe-cell steatosis. Ezi zongezo zinokunceda ukunciphisa ⁤amanqanaba okunamafutha⁢ esibindini kunye nokunciphisa ukudumba. Ukongeza, ii-omega-3s zikwanxulunyaniswa nenani lezinye izibonelelo⁢ kwimpilo yentliziyo.

Iingqwalasela ezikhethekileyo kulawulo lwe-cellular steatosis kubantwana

Kulawulo lwe-cell steatosis ebantwaneni, kubalulekile ukuba kuthathelwe ingqalelo ezinye izinto ezikhethekileyo ezinokuchaphazela ukuxilongwa kunye nonyango lwale meko. Okulandelayo, siza kukhankanya⁢ amanqaku athile abalulekileyo ekufuneka uwagcine engqondweni:

1. ⁤Uvandlakanyo olupheleleyo: Ukumisela ubukho be-cell steatosis ebantwaneni, kubalulekile ukuba kwenziwe uvandlakanyo olucokisekileyo olubandakanya imbali epheleleyo yezonyango yesigulana kunye novavanyo oluneenkcukacha lomzimba. Kubalulekile ukukhumbula ukuba iimpawu zingahluka ngokuxhomekeka kwinqanaba lesi sifo kunye nobunzima baso.

2. Ukutya kunye nendlela yokuphila: I-steatosis yeselula inxulumene kakhulu nokutyeba kunye nendlela yokuphila yabantwana. Ngoko ke, kucetyiswa ukuba kuphunyezwe utshintsho lokutya kunye nokukhuthaza ukusebenza komzimba rhoqo ukunciphisa amanqanaba amanqatha aqokelelwe esibindi. Ukutya okunokulinganisela, okutyebileyo kwiziqhamo, imifuno kunye nokutya okunamafutha aphantsi, kunye nokunciphisa iziselo ezinoshukela, yimilinganiselo ebalulekileyo.

3. Ukubeka iliso kunye nokulandelela: Kubalulekile ukulandelela rhoqo abantwana abafunyaniswe bene-cellular steatosis. Oku kubandakanya ukubeka iliso kumanqanaba e-enzyme yesibindi, ukulawula ubunzima, kunye nokuvavanya ukwakheka komzimba ngamaxesha athile. Kwiimeko ezinzima kakhulu, iimvavanyo ze-imaging ezifana ne-ultrasounds okanye i-MRIs zinokuba yimfuneko.

Iingxaki ezinokwenzeka ze-steatosis yeselula

I-Cellular steatosis yimeko apho iiseli zesibindi ziqokelela amafutha ngaphakathi kuzo. Nangona i-steatosis yeselula ingabangeli iimpawu ezithile, kwiimeko ezithile inokukhokelela kwiingxaki ezinzulu. Apha ngezantsi kukho iingxaki ezinokubakho ezinxulumene nale meko:

Ukungasebenzi kakuhle kwesibindi: Kwezinye iimeko, ukuqokelela kwamafutha kwiiseli zesibindi kunokuphazamisa ukusebenza kwazo ngokufanelekileyo. Oku kunokukhokelela ekuqhubekeni kokuwohloka kokusebenza kwesibindi, okuthetha ubunzima ⁤ekulungiseni i-toxins, i-metabolizing yezondlo kunye nokuvelisa ⁤iiprotheyini ezibalulekileyo zomzimba.

I-hepatitis yotywala: Ukusetyenziswa kotywala ngokugqithisileyo kunye nexesha elide kunokunyusa i-steatosis yeselula kwaye kukhokelela kwi-hepatitis enxilisayo. ⁢Esi sifo sibangela ukudumba kunye nomonakalo esibindini, kwaye sinokubangela amanxeba asisigxina kwithishu yesibindi.

I-steatohepatitis engeyiyo utywala: Ngokunjalo, i-steatosis yeselula inokuvela kwimeko eyaziwa ngokuba yi-steatohepatitis engeyiyo utywala. Ngeli nqanaba, ukongeza ekuqokeleleni kwamafutha kwiiseli zesibindi, ukuvuvukala kunye nomonakalo kwenzeka kwisibindi. Kwezinye iimeko, i-steatohepatitis engeyiyo utywala inokuqhubela phambili kwi-cirrhosis okanye umhlaza wesibindi.

Ukuthintela i-steatosis yeselula

I-Cellular steatosis, eyaziwa ngokuba kukuqokelelwa kwamafutha kwiiseli, yingxaki yezempilo enokuchaphazela amalungu ahlukeneyo, njengesibindi, intliziyo kunye nezintso. Le meko ibonakaliswa ngokuqokelelwa ngokugqithisileyo kwe-lipids ngaphakathi kweeseli, ezinokuthi ziphazamise ukusebenza kwazo ngokufanelekileyo kwaye zibangele umonakalo wexesha elide.

Ukuthintela i-steatosis yeselula, kubalulekile ukugcina ukutya okunokulinganisela kunye nokunempilo, ukuphepha ukusetyenziswa ngokugqithiseleyo kwamafutha ahluthayo kunye neswekile esulungekileyo. Kubalulekile ukubandakanya ukutya okucebileyo kwi-Omega-3 fatty acids ekudleni kwethu, njengentlanzi enamafutha (i-salmon, i-sardines) kunye ne-chia okanye imbewu ye-flax, ekubeni ezi zondlo zinceda ukunciphisa ukuqokelela kwamafutha kwiiseli. Ngokukwanjalo, kububulumko ukunciphisa ukusela utywala, ekubeni ukusela kakhulu kunokuba yingozi. ngenxa yempilo isibindi.

Enye into ephambili ekuthinteleni i-steatosis yeselula kukukhokelela kwindlela yokuphila esebenzayo kunye nokuzilolonga rhoqo. Umsebenzi womzimba ukhulisa i-lipid oxidation kwaye ukhuthaza ukutshiswa kwamafutha, ngaloo ndlela ukukhuthaza impilo kunye nokusebenza kwamaselula. Ukwenza ubuncinci bemizuzu engama-30 yokuzivocavoca okuphakathi ngosuku, njengokuhamba okanye ukukhwela ibhayisekile, kunokunceda kakhulu ukuthintela ukuqokelelwa kwamafutha kwiiseli zakho.

Iimbono zexesha elizayo kunyango lwe-cellular steatosis

Kwiminyaka yakutshanje, ukuqhubela phambili okubonakalayo kuye kwenziwa ekuqondeni nasekunyangweni kwe-cellular steatosis, imeko ebonakaliswa kukuqokelelwa okugqithisileyo kwamafutha kwiiseli zesibindi. Njengoko siqhubeka siphonononga iimbono ezintsha kule ndawo, izicwangciso ezininzi ezithembisayo ziyavela ezinokuguqula indlela yonyango yangoku:

1. Unyango olulolwakho lwamayeza: Ngenkqubela phambili kuphando lwemfuza kunye nemolekyuli, kuthenjwa ukuba amayeza athile anokuphuhliswa ukulwa ne-steatosis yeselula ngokwesiseko somntu ngamnye. Oku kubandakanya ukuchonga ii-biomarkers ezizodwa kunye nokuyila unyango oluhambelana neemfuno kunye neempawu zesigulana ngasinye.

2. Ukumodareyithwa kwe-intestinal microbiota: Kukho ubungqina obandayo obucebisa ikhonkco phakathi kwe-cellular steatosis⁤ kunye nokwakhiwa kwe-gut microbiota⁢. Ngaloo ndlela, unyango olujoliswe ekuguquleni nasekulinganiseni i-microbial flora ingaba nefuthe elibalulekileyo ekuthinteleni kunye nonyango lwesi sifo. Uphando lwangoku lujolise kuphuhliso lweeprobiotics ezithile kunye ne-prebiotics ukujongana ne-cellular steatosis. ngempumelelo.

3. Ungenelelo olungangeneleliyo: Nangona unyango olungenelelayo, olufana notyando lwebariatric,⁢ lunokusebenza ⁢ekunyangeni iimeko ezimandundu zeseli ye-steatosis, iinzame ziyenziwa ukuphuhlisa⁢ ezinye iindlela ezingangeneleliyo kwizigulana. Ukusetyenziswa kwe-laser kunye nobuchwepheshe be-ultrasound zezinye zeenketho eziphantsi kophando,⁢ ezinokunceda ukunciphisa ukuqokelelwa kwamafutha kunye nokuphucula impilo yesibindi ngendlela engaphantsi kobuhlungu.

Imibuzo neempendulo

Umbuzo: Yintoni i-cellular steatosis?
A: I-steatosis yeselula, eyaziwa ngokuba yisifo sesibindi esinamafutha okanye isifo sesibindi esinamafutha, yimeko apho amanqatha aqokelelana kwiiseli zesibindi.

Umbuzo: Ziziphi izizathu ze-steatosis yeselula?
A: Oyena nobangela we-cellular steatosis kukusetyenziswa kotywala ngokugqithiseleyo, ukutyeba ngokugqithiseleyo, uhlobo lwesi-2 seswekile, ukunganyangeki kwe-insulin, ukutya ukutya okunamafutha amaninzi kunye necarbohydrates esulungekileyo, kunye namayeza athile kunye nokuphazamiseka kwemfuza.

Umbuzo: Ziziphi iimpawu ze-steatosis yeselula?
A: Kwiimeko ezininzi, i-cellular steatosis ayinazimpawu kwaye ifunyaniswa ngexesha lovavanyo lwesiqhelo lwezonyango. Nangona kunjalo, ezinye iimpawu zinokubandakanya ukudinwa, ukungakhululeki kwesisu, ukuphelelwa ngumdla, iintlungu zesibindi, kunye neengxaki ezinokubakho ezifana ne-hepatitis kunye ne-cirrhosis.

Umbuzo: Ifunyaniswa njani i-steatosis yeselula?
A: Ukuxilongwa kwe-cellular steatosis kwenziwa ngeemvavanyo zonyango ezifana nokuhlolwa kwegazi ukufumana amanqanaba aphezulu e-enzymes yesibindi kunye neemvavanyo ze-imaging ezifana ne-ultrasound, i-MRI okanye i-CT scan evumela ukuba isibindi esinamafutha sibonakale.

Umbuzo: Yintoni unyango lwe-steatosis yeselula?
A: Unyango lwe-cellular steatosis lusekwe ikakhulu kutshintsho lwendlela yokuphila, njengokwamkela ukutya okunempilo nokulungelelanisiweyo, ukunciphisa umzimba kwimeko yokutyeba ngokugqithiseleyo, ukulawula izifo ezisisiseko ezifana nesifo seswekile kunye nokuyeka ukusela utywala ngokupheleleyo kwimeko ye-alcohol hepatic steatosis. Kwezinye iimeko, amayeza kagqirha angasetyenziselwa ukunyanga iimeko ezithile ezinxulumene ne-cellular steatosis.

Umbuzo: Ziziphi iingxaki ezinokuthi zibekho kwi-cell steatosis?
A: I-steatosis yeselula ingaqhubela phambili iye kwiimeko ezinzima ngakumbi ezifana ne-non-alcoholic steatohepatitis (NASH), ebandakanya ukudumba kwesibindi, i-liver fibrosis, i-cirrhosis, kunye nomhlaza wesibindi. Ukongeza, abo banesibindi esinamafutha anotywala nabo banomngcipheko omkhulu wokuba ne-alcohol hepatitis.

Umbuzo: Ngaba kunokwenzeka ukuthintela i-steatosis yeselula?
A: Ewe, kunokwenzeka ukukhusela i-steatosis yeselula ngokwamkela indlela yokuphila enempilo ebandakanya ukutya okunokulinganisela okuphantsi kwamafutha kunye neswekile ecocekileyo, ukuzivocavoca umzimba rhoqo kunye nokulawula okwaneleyo kwezifo ezifana nokutyeba kunye nesifo sikashukela.

Umbuzo: Ngaba i-steatosis yeselula iyabuyiselwa?
A: Kwiimeko ezininzi, i-cellular steatosis iyabuyiswa ukuba utshintsho olufanelekileyo lwendlela yokuphila luyaphunyezwa kwaye iimeko eziphantsi zinyangwa. Nangona kunjalo, kwiimeko eziqhubela phambili kunye nokuphuhliswa kwe-fibrosis okanye i-cirrhosis, ukuguqulwa ngokupheleleyo kungenakwenzeka, ngoko ke kubalulekile ukufuna ukuxilongwa kwangaphambili kunye nokuthatha amanyathelo okuthintela.

Ukuququmbela

Isishwankathelo, i-cellular steatosis yimeko yonyango ebonakaliswa kukuqokelelwa okungaqhelekanga kweelipids kwiiseli zomzimba. Nangona ngokuqhelekileyo inxulumene nesibindi, le meko inokuchaphazela nezinye izitho kunye nezicubu. I<em>cell steatosis inokubangelwa zizinto ezahlukahlukeneyo, njengokusela kakhulu utywala, ukutyeba ngokugqithiseleyo, isifo seswekile, namayeza athile. Kubalulekile ukugxininisa ukuba i-steatosis yeselula ayisoloko ibonakalisa iimpawu ezicacileyo kwaye ukuxilongwa kwayo kufuna iimvavanyo ezithile kunye nohlalutyo. Unyango lwe-cellular steatosis ikakhulu lubandakanya ukujongana nonobangela, nokuba kungokutshintsha indlela yokuphila, njengokutya okunempilo kunye nokuzilolonga rhoqo, okanye ulawulo lweemeko zonyango ezinxulumeneyo. Ukongezelela, ukuthintelwa kwesi sifo kubandakanya ukuphila ngendlela enempilo nokuphepha ukusela utywala ngokugqithisileyo. Ukuba uyakrokrela⁤ ukuba unokuba unengxaki ye-cell steatosis okanye unenkxalabo enxulumeneyo, kubalulekile ukubonisana⁢ nogqirha⁤ ngoxilongo olululo kunye nesicwangciso sonyango olulolwakho⁤. Nceda ukhumbule ukuba ulwazi olunikeziweyo kweli nqaku lwenzelwe iinjongo zolwazi kuphela kwaye aluthathi indawo yeengcebiso zonyango zobungcali.