Udonga lweSeli yeLactobacilli

Uhlaziyo lokugqibela: 30/08/2023
Umbhali: USebastian Vidal

Intshayelelo: Lactobacilli Cell Wall

I-Lactobacilli zibhaktiriya ze-lactic acid ezisasazwa ngokubanzi kwiindawo zokuhlala ezahlukeneyo, ezifana nesisu sesisu sezilwanyana kunye nabantu, izityalo, ukutya okubilisiweyo kunye neemveliso zobisi. Ezi microorganisms ⁢zaziwa kakhulu⁤ ngokukwazi kwazo ukuvelisa iasidi ye-lactic ⁣ njengemveliso yokugqibela yemetabolism yazo. Ukongeza kolu phawu, i-lactobacilli inesakhiwo esikhethekileyo esiyahlula kwezinye iintsholongwane zebhaktiriya: udonga lweseli.

Udonga lweeseli zebhaktheriya ngumaleko wangaphandle oqinileyo onika inkxaso kunye nokukhusela kwiiseli zebhaktheriya. Ikwadlala indima ebalulekileyo ekusebenzisaneni kweebhaktheriya kunye nokusingqongileyo kunye nezinye ii-microorganisms. Kwimeko ye-lactobacilli, ukubunjwa kunye nokwakhiwa kodonga lweeseli zabo kuye kwaba yinto yokufunda amashumi eminyaka, ngenxa yokubaluleka kwayo kwiinkalo ezahlukeneyo ezifana neshishini lokutya, impilo kunye ne-biotechnology.

Kule nqaku, siza kuhlolisisa ngokucokisekileyo ukubunjwa kunye neempawu zodonga lweseli ye-lactobacilli, sigxininisa impembelelo yayo ekusebenzeni kunye nokusetyenziswa kwezi microorganisms. Ukongeza, siya kuhlalutya ubuchule obusetyenzisiweyo kwisifundo sayo kunye nokusetyenziswa okunokwenzeka kwe-biotechnological ethathwe ekwenziweni kodonga lweseli ye-lactobacilli.

Ngolu hlalutyo, siya kwandisa ulwazi lwethu lwe-lactobacilli kunye nodonga lweeseli zabo, ukubonelela ngombono wobugcisa kunye nokungathathi hlangothi kwezi microorganisms ezibalulekileyo. Ukuqonda isakhiwo kunye nemisebenzi yodonga iseli ye-lactobacilli iya kusivumela ukuba sisebenzise amandla abo kwiindawo ezahlukeneyo njengokuveliswa kokutya kweprobiotic, unyango lwezifo kunye nobunjineli bemfuza.

1.- Isingeniso kwi-Lactobacilli Cell Wall: Ukubaluleka kunye neempawu eziqhelekileyo

I-Lactobacilli liqela lebhaktiriya ye-lactic acid edlala indima ebalulekileyo kwi-lactic acid fermentation kunye nokuveliswa kokutya okubilisiweyo. Ezi bhaktheriya zinodonga olulodwa lweeseli, oluqulunqwe kakhulu yi-peptidoglycan, ebanika uzinzo kunye nokuchasana neemeko ezimbi. Ukubaluleka kwe-lactobacilli kukukwazi kwabo ukwenza i-enzymes eyenza lula ukugaya kunye nokufunxa izondlo, kunye nendima yabo njenge-probiotics, oko kukuthi, ii-microorganisms eziluncedo kwimpilo.

Ngokuphathelele iimpawu eziqhelekileyo ze-lactobacilli, kubalulekile ukukhankanya ukuba iibhaktheriya ze-Gram-positive, oku kuthetha ukuba zigcina i-crystal violet stain kudonga lweseli ngexesha lovavanyo lwe-Gram stain. Ukongeza, zi-anaerobes ezisebenzayo, oko kukuthi, zinokukhula zombini kubukho kunye nokungabikho kweoksijini. Olunye uphawu olubalulekileyo kukukwazi ukuvundisa iintlobo ngeentlobo zesubstrates, ukuvelisa i-lactic acid njengemveliso yokugqibela. Esi sixhobo sokuvundisa sibanika indima ebalulekileyo ekuvelisweni kokutya kobisi okufana neyogathi kunye netshizi.

Udonga lweseli ye-lactobacilli lukwanamanye amacandelo afana ne-teichoic acid, i-lipoteichoic acid kunye ne-polysaccharides enegalelo ekusebenzeni kwayo kunye nokukwazi ukusebenzisana nokusingqongileyo. La malungu, adityaniswe nokuchasana kwawo ne-bile acids kunye nokukwazi kwawo ukwenza ikoloniyali iphecana lesisu, zenza i-lactobacilli ibe liqela lebhaktheriya elibaluleke kakhulu kwicandelo le-microbiology kunye nempilo yabantu. Isishwankathelo, i-lactobacilli ziintsholongwane ezineempawu ezizodwa kwaye zibaluleke kakhulu, zombini kwishishini lokutya nakwimpilo yabantu.

2.- Ukwakhiwa kwesakhiwo sodonga lweseli yeLactobacilli kunye nefuthe layo kumsebenzi wezinto eziphilayo

Udonga lweseli yeLactobacilli sisakhiwo esintsonkothileyo esidlala indima ebalulekileyo kumsebenzi wabo webhayoloji. Ikakhulu iqulunqwe ngeepolysaccharides, iiproteni kunye neelipids ezenza inethiwekhi enemigangatho emithathu ejikeleze iseli. Ezi zixhobo zinika ukuxhathisa kwiseli kwaye zikhusele kwi-osmotic lysis, ngaphezu kokuba noxanduva lokumila kunye nokuzinza kwesakhiwo.

Phakathi kweepolysaccharides ezikhoyo kudonga lweseli yeLactobacilli yi-peptidoglycan kunye ne-polysaccharides ephezulu. I-Peptidoglycan sisakhiwo esiqinileyo esakhiwe ngokuphindaphindiweyo kweeyunithi ze-N-acetylglucosamine kunye ne-N-acetylmuramic acid, ezidityaniswe ngamabhuloho e-peptide. Eli candelo linika ukuqina kunye nokuchasana nodonga lweseli. Ngakolunye uhlangothi, i-polysaccharides yomphezulu iguquguquka ngakumbi kwaye iimolekyuli eziguquguqukayo ezifumaneka kumaleko angaphandle. yodonga lweseli, kwaye badlale indima ebalulekileyo ekusebenzisaneni kweLactobacilli kunye nokusingqongileyo.

Iiprotheyini ezikhoyo kudonga lweseli yeLactobacilli zahlukene kwaye ziyadlala. imisebenzi ephambili kumsebenzi webhayoloji weeseli. Ezi proteni zinokudityaniswa ngokudibeneyo kwi-peptidoglycan, zenze oko kwaziwa ngokuba ziiproteni zokubambelela okanye amakhonkco anqamlezayo. Kukwakho neeproteni ezibophelelayo ezinxibelelana ngokuthe ngqo namacandelo endalo engaphandle, njengeemolekyuli zeswekile okanye iiproteni zematrix ezingaphandle. Ezi ntsebenziswano zibalulekile ekunamatheleni kweLactobacilli kwiindawo, ikholoni yezicubu kunye nokuphendula komzimba.

3.- Imisebenzi ephambili yodonga lweseli⁢ kwi ⁤Lactobacilli: ukhuseleko, uzinzo kunye⁢ nolawulo

Imisebenzi ephambili yodonga lweseli kwiLactobacilli ibaluleke kakhulu kubomi babo kunye nokusebenza ngokufanelekileyo. Ngaloo ndlela, imisebenzi emithathu ephambili ivelele: ukukhusela, ukuzinza kunye nokulawula.

Ukhuseleko: Udonga lweseli yeLactobacilli lusebenza njengesithintelo esikhuselayo kwii-agent zangaphandle, ezifana ne-toxins yebhaktheriya kunye neekhemikhali ezikhoyo kwindawo. Ukongezelela, inika ukhuseleko olongezelelweyo ngokusebenza njengomgca wokuqala wokukhusela ekuhlaselweni kweentsholongwane, ukuthintela ukunamathela kunye nekholoni kwiindawo ze-mucosal zomkhosi.

Uzinzo: Udonga lweseli lukwabonelela ngozinzo lwesakhiwo kwi-⁢Lactobacilli.⁣ Ngenxa yolu phawu, iiseli zebhaktheriya zinokuxhathisa iimeko ezingalunganga zokusingqongileyo, ezifana notshintsho lwe-⁤pH, ubushushu obuphezulu⁢ kunye nokwahluka kwe-osmotic. Ngokunjalo, udonga lweseli luqinisekisa ingqibelelo yeselula kwaye luthintele i-bacterial lysis kunye ne-apoptosis.

Umgaqo: Udonga lweeseli ludlala indima ebalulekileyo kulawulo lweenkqubo zephysiological of Lactobacilli. Ngokusebenzisa amacandelo ahlukeneyo eludongeni, njenge-polysaccharides kunye ne-peptides, i-adhesion, colonization kunye nokusebenzisana nomninimzi kunokuguqulwa. Ngaphezu koko, ukuqina kunye nokubunjwa kwodonga kunokuchaphazela amandla okwenza iimpendulo zokuzivikela komzimba, ezibaluleke kakhulu kwimpilo yamathumbu kunye nempendulo ye-immune yendawo.

4.- Uphononongo lokuhlukahluka kwisakhiwo kunye nokubunjwa kwodonga lweseli yeLactobacilli

ILactobacilli⁢ zifundwa ngokubanzi iimicroorganisms ngenxa yokubaluleka kwazo kwiinkalo ezahlukeneyo ezifana neshishini lokutya kunye nempilo yabantu. Kweli candelo, siza kujongana nesifundo sokuhlukahluka kwisakhiwo kunye nokubunjwa kodonga lweseli yala ma-microorganisms.

Udonga lweseli ye-lactobacilli sisakhiwo esibalulekileyo esinika ukhuseleko kunye nokuqina kwiiseli. Ubukhulu becala yenziwe yi-peptidoglycan, ipholima eyenza i-mesh-dimensional mesh ejikeleze iseli. Nangona kunjalo, umahluko omkhulu ekubunjweni kwale peptidoglycan kuye kwabonwa phakathi kweentlobo ezahlukeneyo kunye neentlobo ze-lactobacilli.

Ukongeza kwi-peptidoglycan, udonga lweseli ye-lactobacilli lunokuthi lube namanye amacandelo afana ne-teichoic acid, i-polysaccharides kunye neeprotheni. Ubukho kunye nobuninzi bala macandelo bunokwahluka ngokubanzi phakathi kweentlobo ezahlukeneyo ze-lactobacilli, ezinegalelo ekuhlukeni kwazo ngokwemigaqo ye-phenotypic kunye neempawu zokusebenza. Lo mahluko kulwakhiwo kunye nokubunjwa kodonga lweseli kunokuchaphazela ukuchasana neemeko ezimbi zokusingqongileyo, ukukwazi ukunamathela kwiindawo kunye nokusebenzisana. kunye nenkqubo immunological, phakathi kweminye imisebenzi yebhayoloji.

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5.- Ukusebenzisana kwe-Lactobacilli Cell Wall kunye nokusingqongileyo kunye nezinye i-microorganisms

Ukusebenzisana kwe-lactobacilli kunye nokusingqongileyo kunye nezinye i-microorganisms yinto ebalulekileyo ekufuneka iqwalaselwe ekufundeni kwezi microorganisms. ILactobacilli ziibhaktheriya eziphawulwa ngokukwazi kwazo ukubilisa iswekile kwaye ziziguqule zibe yi-lactic acid.

Udonga lweseli ye-lactobacilli ludlala indima ebalulekileyo ekusebenzisaneni kwabo kunye okusingqongileyo kunye nezinye ii-microorganisms. Esi sakhiwo sinoluhlu lweempawu ezivumela ukuba zikhusele iibhaktheriya kwiimeko ezimbi kwaye ziququzelele ukunamathela kwayo kwiindawo. Ezinye zentsebenziswano eziphawulekayo ze-lactobacilli zezi:

  • Ukhuphiswano kunye nezinye ii-microorganisms: I-Lactobacilli inokukhuphisana nezinye ii-microorganisms zezondlo kunye nendawo kwindalo. Ukukwazi kwabo ukuvelisa i-lactic acid kunye nezinye izinto ezilwa ne-antimicrobial kubanika inzuzo yokukhuphisana.
  • I-Synergies kunye nezinye ii-microorganisms: Kwezinye iimeko, i-lactobacilli inokuseka i-synergies kunye nezinye ii-microorganisms, ezifana neentlobo ezithile ze-bifidobacteria. Olu nxibelelwano lunokuba luncedo kuzo zombini ii-microorganisms, kuba zinokuncedisana kwimisebenzi yazo ye-metabolic.
  • Ukusebenzisana nomninimzi: I-Lactobacilli inokusebenzisana nomninimzi kwimeko yeprobiotics. Ezi microorganisms zinokwenza ikoloniyali kwindlela yokugaya umntu kwaye zenze iziphumo eziluncedo kwimpilo, njengokuphucula ukusebenza kwamathumbu kunye nokuvuselela amajoni omzimba.

Ukuqukumbela, ukusebenzisana kwe-lactobacilli kunye nokusingqongileyo kunye nezinye ii-microorganisms sisihloko esibaluleke kakhulu kwi-microbiology. Ezi ⁤bhaktheriya zisebenzisa udonga lweseli kunye nezinye iindlela zokukhuphisana nezinye iimicroorganisms, ukuseka intsebenziswano kwaye kuzuze umamkeli. Uphononongo lolu nxibelelwano lunokuba negalelo kuphuhliso lweeprobiotics kunye ezinye izicelo iteknoloji yebhayoloji.

6.- Inzuzo enokubakho kwimpilo yabantu ehambelana nobukho beLactobacilli Cellular Wall

Ubukho beLactobacilli Cell Wall emzimbeni womntu bubonelela ngothotho lwezibonelelo zempilo ezinokubakho. Ezi zibonelelo zibangelwa kwiipropati ezizodwa ze-lactobacilli, ezinokuthi zibe negalelo ekuphuculeni umthamo we-immune system kunye nokukhuthaza ukulinganisela okunempilo kwi-intestinal microbiota.

Ezinye zezibonelelo zempilo ezinokubakho ezinxulumene neLactobacilli Cell Wall zezi:

  • Ukomeleza⁤ amajoni omzimba: I-Lactobacilli inamandla okuvuselela ukuveliswa kweeseli ezithile zokuzivikela, ezinokunceda ukuqinisa ukusabela kwamajoni omzimba kwizifo kunye nezifo.
  • Ukuphucula impilo yamathumbu: ILactobacilli inokunceda ukugcina ulungelelwaniso olusempilweni kwi-gut microbiota ngokuthintela ukukhula kweebhaktheriya eziyingozi. Oku kunokunceda ukuphucula ukugaya, ukufunxa izondlo kunye nokunciphisa iimpawu ezinxulumene nokuphazamiseka kwamathumbu amathumbu afana nesifo sohudo.
  • Ukukhuthaza impilo ye-vaginal: Ezinye iintlobo ze-lactobacilli zinokubakho ngokwemvelo kwilungu lobufazi kwaye zidlala indima ebalulekileyo ekuthinteleni usulelo lobufazi, olufana nezo zibangelwa yi-Candida bacteria.

Ezi ⁢zezinye zeenzuzo ⁢ezempilo ezinokuthi zinxulunyaniswe ⁤Lactobacilli ⁤Udonga Lweseli. Nangona kunjalo, kubalulekile ukukhumbula ukuba uphando kule nkalo lusaphuhliswa kwaye uphando oluninzi luyafuneka ukuze kuqinisekiswe kwaye kuqondwe ngokupheleleyo imiphumo emihle yezi microorganisms emzimbeni womntu.

7.- ⁢Iimpembelelo kushishino lokutya kunye neprobiotics: izicelo kunye ⁤ nokulungiswa kodonga lweseli yeLactobacilli

Uphando ⁢kuchaphazeleko kukutya kunye neshishini leprobiotic lityhile izicelo ezahlukeneyo kunye namathuba okuphucula udonga lweseli ⁤Lactobacilli.⁤ Ezi microorganisms, zikhona ngokwendalo Ekutyeni okufana ne-yogurt, baye baboniswa ukuba banemiphumo emihle kwimpilo yabantu, ukuphucula ukugaya kunye nokuqinisa amajoni omzimba. ⁤Ngokuguqulwa kodonga lwayo lweseli, kunokwenzeka ukunyusa iimpawu zayo zeprobiotic kunye nokwandisa ukusetyenziswa kwayo kwiimveliso zokutya⁤ kunye nezongezo zokutya.

Olunye⁤ lwezona zicelo zibalaseleyo⁢ zokwenziwa⁢ ukwenziwa ngcono kodonga lweseli yeLactobacilli kukuveliswa kokutya okusebenzayo. Oku kutya kuqulethe izithako ezibonelela ngezibonelelo zempilo ezongezelelweyo ngaphaya kwexabiso labo lesondlo elisisiseko. Ngokuphucula ukukwazi kweLactobacilli ukunamathela kudonga lwamathumbu kwaye uphile ngokudlula kwindlela yokugaya, ukutya okusebenzayo okunomxholo ophezulu weprobiotics esebenzayo kunokufumaneka. Oku kubaluleke ngakumbi kubantu abaneengxaki zesisu okanye abafuna ukomeleza i-microbiota yabo yamathumbu.

Enye intsimi apho iimpembelelo zokuphucula udonga lweeseli zeLactobacillus zijongwa kushishino lweprobiotics. Uphononongo lwakutsha nje ⁤ lubonise ukuba uhlengahlengiso lodonga lweseli lunganyusa ⁢uzinzo kunye nokusebenza ⁤kwezi ⁣microorganisms ngexesha⁤ imveliso kunye nogcino. Ukongezelela, kuye kwaphawulwa ukuba ukulungiswa kodonga lweseli kunokuphucula ukuchasana kwayo neemeko ezimbi, ezifana ne-asidi yesisu, efunekayo ukuqinisekisa ukusebenza kakuhle kweeprobiotics. Oku kuqhubela phambili kwitekhnoloji yeLactobacillus kuvula amathuba amatsha kuphuhliso lweemveliso zeprobiotic. umgangatho ophezulu ⁤kunye⁢ nokusebenza.

8.- Iindlela zophando kunye nobuchule bokuhlalutya kwisifundo seCell Wall Lactobacilli

Udonga lweseli yeLactobacilli luyinkalo ebalulekileyo yokuqonda isakhiwo kunye nomsebenzi wabo. Ukuphanda kunye nokuhlalutya olu phawu, iindlela ezahlukeneyo kunye nobuchule zisetyenziselwa ukufumana ulwazi olunzulu malunga nokubunjwa kwayo kunye neempawu. Okulandelayo, siza kubonisa ezinye zezona ndlela zisetyenziswayo kwisifundo sodonga lweseli yeLactobacilli:

1. Ukudluliselwa kwe-electron microscopy (TEM): Obu buchule buvumela ukuba sifumane⁤ imifanekiso ephezulu yodonga lweseli yeLactobacilli kwinqanaba lemicroscopic. Ngokusebenzisa i-TEM, amacandelo ahlukeneyo odonga lwamaseli angabonwa, njenge-teichoic acids, i-polysaccharides kunye neeprotheni Ukongeza, le ndlela ivumela ukuchonga utshintsho kwisakhiwo sodonga lweseli ekuphenduleni iimeko zokusingqongileyo okanye unyango oluthile.

2. Umaleko omncinci wechromatography: Ichromatography yomaleko omncinci bubuchule obusetyenziselwa ukwahlula kunye nokuhlalutya amacandelo ahlukeneyo odonga lweseli yeLactobacilli. Ukusebenzisa le ndlela, kunokwenzeka ukuchonga i-lipids, i-polysaccharides kunye nezinye i-metabolites ezikhoyo kwindonga yeseli. Ukongeza, i-chromatography yomaleko omncinci ivumela ukumisela ukubunjwa kodonga lweseli kunye nokwazi utshintsho olunokuthi lwenzeke ekuphenduleni iimeko ezahlukeneyo zenkcubeko.

3. I-Fourier iguqule i-infrared spectroscopy (FTIR): I-FTIR bubuchule obuvumela ukuba sihlalutye ubume bekhemikhali bamacandelo akhoyo kudonga lweseli yeLactobacilli. Ukusebenzisa obu buchule, i-spectra ifunyenwe enika ulwazi malunga namaqela asebenzayo akhoyo kumacandelo odonga lweseli, njengamabhondi e-peptide, amaqela e-carboxyl kunye namaqela e-hydroxyl. I-FTIR bubuchule obuluncedo bokumisela utshintsho kwimichiza yodonga lweseli kunye nokuthelekisa iintlobo ezahlukeneyo zeLactobacilli ngokwendlela yokwakheka kwazo.

9.- Imingeni kunye nemibono yexesha elizayo kuphando lweLactobacilli Cell Wall

Imingeni kunye nemibono yexesha elizayo kuphando kwi-Lactobacilli Cell Wall

Uphando lweCell Wall Lactobacilli lujongene nemingeni eyahlukeneyo kwaye lubonisa iimbono ezinomdla kwixesha elizayo. Ngezantsi eminye yemiceli mngeni ephambili ekufuneka yoyiswe kunye namathuba asazayo:

Imingeni:

  • Chonga kwaye uqonde ngcono ukubunjwa kunye nesakhiwo sodonga lweseli yeLactobacilli, ekubeni uyilo lwayo luyimfuneko kumsebenzi wayo webhayoloji kunye nokusetyenziswa kweshishini.
  • Ukusombulula ukungabikho kweendlela ezisebenzayo zokubonakalisa kunye nokulinganisa amacandelo ahlukeneyo eludongeni lweseli ngokukhawuleza nangokuchanekileyo.
  • Ukoyisa imida yetekhnoloji kunye nemali ukwenza uphando kunye nokuphuhlisa iintlobo ezintsha zeLactobacilli ezineepropathi eziluncedo kwimpilo kunye nokusetyenziswa kokutya kunye neziselo.
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Amathuba exesha elizayo:

  • Faka isicelo sobuchule bobunjineli bezofuzo ukuguqula ukubunjwa kodonga lweseli yeLactobacilli kunye nokuphucula iimpawu zabo ngokuchasana neemeko ezinzima, ukuveliswa kweemetabolites, ukusebenzisana nomninimzi, phakathi kwabanye.
  • Phonononga amandla eLactobacilli kwiyeza lomntu, njengee-arhente zonyango kunyango lwezifo zesisu, i-immunomodulation kunye nokuthintela izifo ezingapheliyo.
  • Phuhlisa ⁤imodeli entsha yokuvubela kunye ne-bioproducts evela kwiLactobacilli eneempawu ezithile ezisebenzayo, ⁤ukujongana neemfuno ezikhulayo kunye neemfuno ⁤ kushishino lokutya kunye ne-nutraceutical.

Ukuqukumbela, ngaphandle kwemingeni ekhoyo, uphando kwiCell Wall Lactobacilli ibonelela ngendima ethembisayo yokuqhubela phambili kwesayensi kunye nobuchwepheshe. Ukuqonda okungcono kwesakhiwo kunye nomsebenzi wodonga lweseli yezi microorganisms kubalulekile ukuxhaphaza ngokupheleleyo amandla abo kwiinkalo ezahlukeneyo zesicelo.

10.- Iingcebiso zokusetyenziswa ngokufanelekileyo kweLactobacilli ⁤Isellula ⁤Udonga kwishishini

Iingcebiso zokusetyenziswa ngokufanelekileyo kweLactobacilli Cell Wall kushishino

Ukusetyenziswa kwe-Lactobacilli ⁣Cell Wall kwishishini lokutya yinto eqhelekileyo eyandayo ngenxa yoncedo olunikezwa zezi ⁤microorganisms ⁤ malunga nempilo kunye nomgangatho wemveliso. Nangona kunjalo, ukuqinisekisa ukusetyenziswa okusebenzayo kunye nokwandisa iziphumo zayo, kuyimfuneko ukulandela iingcebiso ezithile:

1. Ukhetho olufanelekileyo lweLactobacilli​ Cell Wall: Kubalulekile ukukhetha iintlobo ezithile zeCell Wall Lactobacilli ezihambelana neemveliso kunye neenkqubo zeshishini ekuthethwa ngalo. Uhlobo ngalunye luneempawu kunye neenzuzo ezithile, ngoko ke, kubalulekile ukufuna iingcebiso kwaye ukhethe eyona ifanele iimfuno ezithile zenkampani.

2. Ulawulo olupheleleyo lweemeko zokubilisa: Ukuqinisekisa ukusebenza kakuhle kweLactobacilli Cellular Wall, kubalulekile ukugcina ulawulo olungqongqo lweemeko zokuvutshelwa. Oku kubandakanya ukubeka esweni rhoqo ubushushu, i-pH, ukugxininiswa kwezondlo, kunye nexesha lokuvundiswa Indawo efanelekileyo ibalulekile ukukhuthaza ukusebenza kunye nokuphindaphinda kweCell Wall Lactobacilli, kunye nokusebenza kwayo okuphezulu.

3. Ukubeka iliso nocazululo⁢ lweziphumo: ⁤Kucetyiswa ukuba kuqhutyekwe esweni rhoqo kunye nohlalutyo lweziphumo ezifunyenwe emva kokusetyenziswa kweLactobacilli⁤ Cell Wall. Oku kubandakanya ukubeka esweni ukuphuculwa komgangatho wemveliso, ukuvavanya impembelelo yayo kubomi beshelufa kunye nokhuseleko lokutya, kunye nokubonelela ngengxelo kubathengi ukuvavanya ukwamkelwa. Idatha eqokelelweyo⁤ iyakuvumela​ukuhlengahlengisa kunye nokwandisa isicelo⁤ zezi ⁢microorganisms ngokufanelekileyo kwaye isebenza kwixesha elizayo.

11.- Uvavanyo lwempembelelo yodonga lweseli yeLactobacillus kwimpilo yezilwanyana kunye nokusetyenziswa kwayo kumayeza ezilwanyana

Udonga lweseli yeLactobacilli, uhlobo lwebhaktheriya enenzuzo, luvuse umdla omkhulu kuluntu lwenzululwazi ngenxa yempembelelo enokubakho kwimpilo yezilwanyana. Uphononongo oluninzi luye lwenziwa ukuvavanya iziphumo zolu donga lweseli kwiintlobo ezahlukeneyo zezilwanyana, njengeenkomo, iihagu kunye neenkukhu. Iziphumo ukuza kuthi ga ngoku zibonisa ukuba ukulawulwa kweLactobacilli kunye nodonga lweeseli zabo kunokukhuthaza uluhlu lwezibonelelo zempilo kwizilwanyana, kunye nokubonelela ngamathuba okusetyenziswa kwabo kwiyeza lezilwanyana.

Ezinye zeziphumo eziphawulekayo kolu vavanyo ziquka:

  • Ukuphuculwa komsebenzi wesisu: Udonga lweseli yeLactobacilli lubonakaliswe ukuba luneempawu ze-prebiotic kwaye lunokukhuthaza ukukhula kwebhaktiriya eluncedo kumzila wesisu wezilwanyana. ukuqinisa umsebenzi womqobo wamathumbu.
  • Ukuvuselela amajoni omzimba: Kuye kwaphawulwa ukuba ukulawulwa kweLactobacilli kunye nodonga lwayo lweeseli kunokunyusa ukusabela komzimba kwizilwanyana, ngaloo ndlela komeleza inkqubo yabo yokukhusela kwizifo ezahlukeneyo kunye neentsholongwane.
  • Ukunciphisa uxinzelelo kunye nokuvuvukala: Kuye kwacetyiswa ukuba udonga lweseli yeLactobacilli lunokuba nemiphumo emihle ekunciphiseni uxinzelelo kunye nokuvuvukala kwezilwanyana ngokulawula impendulo. yenkqubo yemithambo-luvo kunye nebhalansi ye-cytokines ene-proinflammatory.

Ezi ziphumo zithembisayo zivula iimbono ezintsha kwintsimi yezilwanyana, apho ukufakwa kweLactobacilli kunye nodonga lwabo lweeseli ekutyeni okanye njengezongezelelo zondlo kunokuba yizicwangciso ezisebenzayo zokuphucula impilo kunye nokuphila kakuhle kwezilwanyana. Nangona kunjalo,⁢ kubalulekile ukuqaqambisa ukuba uphando olungakumbi lusafuneka ukuze kuqondwe ngokupheleleyo iindlela ⁢isenzo kunye⁢ nokumisela⁢ awona mathamo afanelekileyo kuhlobo ngalunye lwesilwanyana.

I-12.- Izicwangciso ezinokwenzeka zokuguqula udonga lweeseli zeLactobacilli ukuphucula ukusebenza kwazo

Enye yezona ndlela zithembisayo zokuphucula ukusebenza kweLactobacilli kukuguqulwa kodonga lweeseli zabo. Ngokwenza oku, sifuna ukunyusa amandla ayo okunamathela kwiiseli ze-epithelial zamathumbu, ukuphucula ukuzinza kwayo ngexesha lokugaya kunye nokuphucula amandla ayo okukhupha i-bioactive compounds enenzuzo kwimpilo.

Kukho izicwangciso ezahlukeneyo zokuphumeza olu tshintsho, phakathi kwazo oku kulandelayo:

  • Uhlengahlengiso lokuqamba: Iqukethe ukuguqula umlinganiselo wamacandelo akhoyo kudonga lweseli yeLactobacilli, unokwandisa inani le-teichoic acids kunye ne-exopolysaccharides, iimolekyuli ezaziwa ukukhuthaza ukunamathela kwiiseli zamathumbu.
  • Ukudityaniswa kweemolekyuli ze-bioactive: Kubandakanya ukwazisa izinto ezisebenzayo kudonga lweseli yeLactobacilli ukuphucula iipropathi zabo zokusebenza. oku Inokufezekiswa ngobuchule bobunjineli bemfuza, njengokungeniswa kofuzo oluyikhowudi yokuveliswa kweekhompawundi eziluncedo empilweni, njengee-acids ezifatty chain emfutshane.
  • Iseli eludongeni: Ibandakanya ukugubungela udonga lweseli yeLactobacilli ngezinto ezikhuselayo okanye ukuzifaka kwiimatriki zepolymeric. ⁢Oku kunceda ekuphuculeni⁤ ukuxhathisa kwayo kwi-asidi yesisu kunye ne-enzymes yokugaya, kwaye iququzelele ukukhululwa kwayo okulawulwayo emathunjini.

Ezi zicwangciso zokuguqula udonga lweeseli zeLactobacilli zimele indawo ethembisayo yophando kwicandelo le-biotechnology yokutya kunye ne-microbiology esetyenzisiweyo. Ukusetyenziswa kwayo kunokuvumela ukuyila kweentlobo zeLactobacilli kunye neepropati eziphuculweyo, ezinokuthi zisetyenziswe njengeprobiotics esebenzayo ukukhuthaza impilo yamathumbu kunye nokukhusela izifo.

13.- Izifundo ezithelekisa ⁢zodonga lweseli ⁢lweLactobacilli ⁣ kwiintlobo ezahlukeneyo kunye noxinzelelo

Udonga lweseli yeLactobacilli, i-genus ye-gram-positive bacteria, ibe ngumxholo wezifundo ezithelekisayo ukuqonda isakhiwo kunye nokubunjwa kwayo kwiintlobo ezahlukeneyo kunye neentlobo ezivumela ukuba sihlalutye ukuhluka okunokwenzeka kumacandelo odonga lweseli. kunye neempembelelo zabo zokusebenza kunye nokusetyenziswa okunokwenzeka kwishishini lokutya kunye nezempilo.

Kuphononongo oluthelekisayo, amacandelo aphambili odonga lweseli yeLactobacilli achongiwe, njengale:

  • I-Peptidoglycan: i-polymer eyenziwe ngamatyathanga e-glucosamine kunye ne-muramic acid, ebonelela ngokumelana nomatshini kudonga lweseli.
  • I-Teichoic acids: Iipolymers ze-anionic ezichaphazela intlawulo engalunganga yodonga lweseli kwaye inokudlala indima ekunamatheleni kwiindawo.
  • Iiprotheni ezibophezelayo ze-Peptidoglycan: zidlala indima ebalulekileyo kumsebenzi we-enzymatic onxulumene nokudibanisa kunye nokulungiswa kodonga lweseli.
Umxholo okhethekileyo- Cofa Apha  Uyenza njani iPC ukude

Ukongeza kokuvavanya amacandelo odonga lweseli, izifundo zokuthelekisa ziye zahlalutya kwakhona ukungafani kwintlangano kunye nesakhiwo seLactobacilli. Ezi ziphumo zibonise ukuba ezinye iintlobo kunye neentlobo zinokuba nodonga olungqingqwa lweeseli okanye umlinganiselo ophezulu we-teichoic acids. Ezi zintlukwano zinokunxulunyaniswa nokwahluka kokuchasana nomkhosi wokugonyeka okanye izinto ezilwa ne-antimicrobial, ezibonelela ngombono opheleleyo weentlobo ezahlukeneyo zeLactobacilli kunye namandla azo okusetyenziswa kwizicelo ⁤ezahlukeneyo.

14.- Izigqibo kunye nemibono yokugqibela kwiLactobacilli Cellular Wall: indlela eya kulwazi olukhulu kunye nokusetyenziswa

Ukuqukumbela, uphononongo lweendonga zeeseli ze-lactobacilli luveze ulwazi olubalulekileyo lokuqonda ngcono ibhayoloji yabo kunye nokusetyenziswa okunokwenzeka. Ukusebenzisa iindlela zokulandelelana kwe-genomic, kuye kwenzeka ukuchonga izakhi zofuzo ezitsha ezibandakanyekayo kwi-synthesis yodonga lwamaseli ezi microorganisms, ezisisondeza kumbono opheleleyo wesakhiwo kunye nomsebenzi wabo. Ukongezelela, kuye kwaboniswa ukuba udonga lwamaseli i-lactobacilli luneempawu ze-immunomodulatory kunye nokukwazi ukusebenzisana ne-intestinal mucosa, enokuthi ibe nefuthe ekukhuseleni nasekunyangeni izifo zamathumbu.

Ngokombono, ikamva lophando kwiindonga zeseli ye-lactobacilli libukeka lithembisa. Kulindeleke ukuba ukuqhubela phambili kwezobuchwepheshe kuya kusivumela ukuba sifunde ngomlinganiselo omkhulu ukusebenzisana phakathi kwezi microorganisms kunye nokusingqongileyo, kunye nokuchonga iikhompawundi ezintsha ze-bioactive kunye neendlela zokusebenza. Ezi ziphumo azikwazanga ukwandisa ulwazi lwethu malunga neendonga zeeseli ze-lactobacilli, kodwa zibonelela ngeendlela ezintsha zonyango zonyango lwezifo ezahlukahlukeneyo ezinxulumene nenkqubo yesisu kunye ne-immune system.

Isishwankathelo, uphononongo lwe-lactobacilli eludongeni lweeseli lukhokelele ekufumaneni imiba enomdla yebhayoloji yabo kunye nokusetyenziswa okunokwenzeka. Ngenkqubela nganye ekuqondeni kwethu ezi microorganisms, amathuba amatsha avulekele ukusetyenziswa kumashishini okutya, amayeza kunye nezempilo. Njengoko siqhubeka nokuphonononga umhlaba wabo we-microscopic, siqinisekile ukuba sifumana izibonelelo ezingakumbi kunye nokusetyenziswa kweendonga zeeseli ze-lactobacilli, okwenza le ndawo yophando ibe yindlela yolwazi kunye namathuba amakhulu.

Imibuzo neempendulo

Umbuzo: Yintoni iLactobacilli ⁢Udonga lweSeli?
A: I-Cell Wall Lactobacilli ziibhaktheriya ze-lactic acid ezibonakaliswa ngokuba nenwebu yeseli etyebileyo kwi-polysaccharides, ebanika ukuxhathisa okukhulu kunye nokukwazi ukuphila kwindlela yesisu.

Umbuzo: Yintoni ukubaluleka kweLactobacilli Cell Wall?
A: I-Cell Wall I-Lactobacilli ineenzuzo ezininzi zempilo, njengoko zomeleza amajoni omzimba, ziphucula ukugaya, zilawula iintyatyambo zamathumbu kwaye zikhusela izifo zesisu. Kwakhona kuye kwaboniswa ukuba banokuba nemiphumo emihle ekunciphiseni i-cholesterol kunye nokuthintela iintlobo ezithile zomhlaza.

Umbuzo: Isebenza njani iLactobacilli Cell Wall emzimbeni?
A: I-Cell Wall I-Lactobacilli isebenze ngokukodwa kwi-gastrointestinal tract, apho ibambelela kwi-intestinal mucosa kwaye ikhuphisane ne-microorganisms ye-pathogenic, ukuthintela ukwanda kwabo kunye nokunamathela kwiiseli zamathumbu. Ukongezelela, bakhuthaza ukuveliswa kwe-lactic acid kunye nezinye izinto ezilwa ne-antimicrobial ezivimbela ukukhula kweebhaktheriya ezinobungozi kunye nefungi.

Umbuzo: Yeyiphi imithombo yeLactobacilli Cell Wall?
A: I-Cell Wall Lactobacilli ifumaneka kukutya okuvundisiweyo okufana neyogathi, itshizi, i-sauerkraut kunye ne-miso. Zinokufunyanwa kwakhona ngezongezo zokutya kunye neemveliso ezithile zeprobiotic.

Umbuzo: Ngaba kukho ukuchasana okanye iziphumo ebezingalindelekanga ezinxulumene nokusetyenziswa kweCell Wall Lactobacilli?
A: Ngokubanzi, iCell Wall Lactobacilli ikhuselekile kwaye inyamezeleke kakuhle. Nangona kunjalo, kwiimeko ezinqabileyo kakhulu, abanye abantu banokufumana iimpawu ezincinci zesisu ezifana ne-flatulence, i-bloating, okanye isifo sohudo. Isilumkiso sikwacetyiswa kubantu abanamajoni omzimba abuthathaka okanye kwizigulana ezisesibhedlele, njengoko kunokubakho umngcipheko omncinci wosulelo.

Umbuzo: Leliphi idosi ecetyiswayo yeLactobacilli Cell Wall?
A: Idosi ecetyiswayo ye-Lactobacilli Cell Wall inokwahluka ngokuxhomekeke kwimveliso kunye nemeko yomntu ngamnye Kucetyiswa ukuba ulandele imiyalelo yomenzi okanye udibane nochwepheshe bezempilo ukumisela idosi efanelekileyo kwimeko nganye.

Q: Kuthatha ixesha elingakanani ukuqaphela izibonelelo zeLactobacilli Cell Wall?
A: Izibonelelo zeLactobacilli Cell Wall zinokwahluka. yomntu komnye kwaye⁢ kuxhomekeka ⁢kwizinto ezininzi, ezinje ngedosi, usetyenziso rhoqo kunye ⁣nempilo jikelele yomntu ngamnye. iiveki ezimbalwa, ngelixa ezinye izibonelelo zinokufuna ukusetyenziswa ixesha elide ukuze kubonakale.

Umbuzo: Ngaba kukhuselekile ukusebenzisa iLactobacilli Pared ⁣Cellular ngexesha lokukhulelwa okanye xa uncancisa?
A: Ngokubanzi, i-Lactobacilli⁤ Udonga lweSeli ⁢ ithathwa njengekhuselekile ngexesha⁢ lokukhulelwa kunye nokuncancisa. Nangona kunjalo, kucetyiswa ukuba udibane nodokotela ngaphambi kokuba uqale ukusetyenziswa kwayo, ngakumbi kwiimeko zokukhulelwa okunobungozi okanye phambi kweemeko ezithile zonyango.

Umbuzo: Ngaba i-Lactobacilli Cellular Wall inokudibaniswa namanye amayeza?
A: Kwiimeko ezininzi, i-Lactobacilli Cell Wall inokudityaniswa ngaphandle kweengxaki namanye amayeza. Nangona kunjalo, kubalulekile ukubonisana nogqirha okanye usokhemisti ukuze uqiniseke ukuba akukho ukusebenzisana okungalunganga kunye namayeza athile. Kwakhona kubalulekile ukulandela iingcebiso zomenzi malunga nexesha lokusela kunye nokuhlukana nokuthatha amanye amachiza.

Umbuzo: Ziziphi iintlobo eziphambili zeCell Wall Lactobacilli ezisetyenziselwa izongezo kunye neemveliso zeprobiotic?
A: Ezinye zezona ntlobo zixhaphakileyo zeCell Wall Lactobacilli yiLactobacillus ⁢rhamnosus, Lactobacillus ‍plantarum, Lactobacillus acidophilus kunye neLactobacillus casei. Ezi ntlobo zibonakaliswe ukuba zineempembelelo zempilo kwaye zifundiswa ngokubanzi kuphando lwezenzululwazi ezahlukeneyo.

Isiphelo

Ukuqukumbela, iCell Wall Lactobacilli ziinkcubeko zeprobiotic ezigqamayo ngenxa yokukwazi kwabo ukomeleza amajoni omzimba kunye nokuphucula impilo yamathumbu. Ukwakhiwa kweendonga zeeseli zabo ezikhethekileyo kubanika iimpawu ezikhethekileyo, ezifana nokukwazi ukunamathela kwi-intestinal mucosa kunye nokumelana neemeko ezimbi zendlela yesisu.

Ezi microorganisms ziluncedo ziye zaba ngumxholo wezifundo ezininzi zesayensi, ezixhasa ukusebenza kwazo kuthintelo kunye nonyango lwezifo ezahlukeneyo zesisu, kunye nolawulo lwezifo kunye nokomeleza amajoni omzimba.

Uphando kwiCell Wall Lactobacilli luyaqhubeka, ngenjongo yokuqonda ngcono ukumodareyitha kwabo amajoni omzimba kunye nokusebenzisana kwabo nezinye iimicroorganisms ezikhoyo emathunjini. Ukongeza, itekhnoloji entsha iyaphononongwa ukuphucula imveliso kunye nokuzinzisa ezi probiotics, ngaloo ndlela ziqinisekisa ukusebenza kwazo kunye nokusebenza konyango.

Isishwankathelo, i-Lactobacilli Cell Wall imele isixhobo esinamandla kwintsimi ye-microbiota kunye nempilo yamathumbu. Indima yabo ekukhuthazeni ukulungelelaniswa kwe-microbial kwi-gastrointestinal tract kunye nokukwazi kwabo ukumodareyitha amajoni omzimba kubenza babe yindlela ethembisayo yokukhusela kunye nonyango lweemeko ezahlukeneyo.